Abstract:
OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, along with cardiac lipid profiles was assessed. RESULTS:Supplementation of HFD to rats significantly increased body mass index, obesity index parameters, and cardiac lipid profile along with notable oxidative stress and inflammation. Additionally, BCA treatment in obese rats demonstrated a superior therapeutic action by restoring the altered parameters to almost normal levels. Simultaneously, BCA increased the activities and mRNA expressions of enzymatic antioxidants by upregulating the Nrf-2 pathway and inhibiting the NF-κB cascade. CONCLUSION:BCA may attenuate obesity and its associated cardiomyopathy by suppressing oxidative stress and inflammation through activation of the Nrf-2 pathway and inhibition of NF-κB activation.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi Sdoi
10.1080/13813455.2021.1874017subject
Has Abstractpub_date
2021-01-20 00:00:00pages
1-16eissn
1381-3455issn
1744-4160pub_type
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