Abstract:
:Objective: To evaluate the diagnostic and prognostic value of biomarkers and new bioscore in septic patients in intensive care unit (ICU).Materials and methods: A study was conducted on septic and non-septic patients in ICU. Diagnostic and prognostic values of C-reactive protein (CRP), procalcitonin (PCT), Sequential Organ Failure Assessments (SOFA) score and new bioscore were analysed statistically.Results: A total of 226 patients were enrolled in the study. In septic patients, PCT, SOFA and bioscore were found significantly increased (p = .007, p = .001 and p = .001, respectively). The AUC value of bioscore was higher than PCT and SOFA in septic patients. SOFA was found to be more significant prognostic marker than bioscore in predicting 28-day mortality. The prognostic value of bioscore and SOFA was similar for predicting 90-day mortality.Conclusions: The new bioscore formed by combination of CRP, PCT and SOFA score may be useful in early diagnosis of sepsis.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Sen P,Demirdal T,Nemli SA,Sencan Adoi
10.1080/13813455.2019.1677720subject
Has Abstractpub_date
2019-11-05 00:00:00pages
1-6eissn
1381-3455issn
1744-4160pub_type
杂志文章abstract::Separating proteins according to two different gel-electrophoretic methods not only increases the resolution power for highly complex samples when compared to one-dimensional separations, but is also a valuable tool for protein and protein complex characterization. There are a number of different electrophoresis metho...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2014.945188
更新日期:2014-12-01 00:00:00
abstract::The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1787457
更新日期:2020-08-06 00:00:00
abstract::The transport system for the cytokine tumor necrosis factor-alpha (TNFalpha) at the blood-brain barrier (BBB) enables an enhanced yet saturable entry of TNFalpha from blood to the CNS. This review focuses on the selective upregulation of the transport system for TNFalpha at the BBB that is specific for type of patholo...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.109.4.350.4238
更新日期:2001-10-01 00:00:00
abstract::Diabetes represents an important public health problem. Recently, new molecular targets have been identified and exploited to treat this disease. Due to its pivotal role in glucose homeostasis, glucokinase (GCK) is a promising target for the development of novel antidiabetic drugs; however, pharmacological agents that...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1627458
更新日期:2019-06-18 00:00:00
abstract::Background: Oxidative stress, has been shown to play an important role in the pathophysiology of cardiac remodelling and heart failure. The aim of study is effect of arginine vasopressin (AVP) on apoptosis of cardiomyocyte via its receptors.Materials and methods: The cell viability effect of AVP in H9C2 cardiomyocytes...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1729816
更新日期:2020-03-06 00:00:00
abstract:BACKGROUND:A substantial body of evidence links sex hormones, diet, excess body weight and physical activity to the risk of developing cancer at several sites common in affluent countries. The hypothesis that high circulating levels of insulin could be the underlying factor increasing cancer risk has been proposed. Epi...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,meta分析
doi:10.1080/13813450801954451
更新日期:2008-02-01 00:00:00
abstract::Folliculo-stellate cells (FS-cells) in the anterior pituitary gland are star-shaped cells and form tiny follicles. FS-cells are positive for S-100 protein and produce many cytokines or growth factors, such as interleukin-6 (IL-6), leukemia inhibitory factor (LIF), basic fibroblastic growth factor (bFGF) and vascular e...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.110.1.50.911
更新日期:2002-04-01 00:00:00
abstract::A range of epidemiological evidence from several diverse populations, supports the hypothesis that risk of essential hypertension, coronary heart disease and non-insulin dependent diabetes is, in part, programmed by intrauterine nutritional status. Animal models developed to investigate the mechanisms that are respons...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.111.1.8.15136
更新日期:2003-02-01 00:00:00
abstract::Background: This study aimed to investigate the association of calorie and carbohydrate intake with tumour grade in early detection of breast cancer (BC) in Iranian women.Materials and methods: This case-control study carried out on 62 women with high grade BC and 93 women with low grade BC. Information about confound...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1754430
更新日期:2020-05-06 00:00:00
abstract::Objective: To explore the probable in vitro, in situ and in vivo mechanisms of gallic acid (GA) and p-coumaric acid (PCA) as anti-hyperglycemic agents.Animals and methods: Male albino rats were allocated into four groups, group1 was used as normal control. Group 2 was established as a diabetic control and group3 and 4...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1762659
更新日期:2020-05-13 00:00:00
abstract::Context: Small peptides as multifunctional biomolecules can prevent the metabolic disorders such as diabetes. Objective: The purpose of this study was to investigate the effects of small peptides on the enzymes and histopathology of the liver in mice exposed to diabetes. Methods: Di- and tri-peptides containing prolin...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1662453
更新日期:2019-09-09 00:00:00
abstract::We investigated the effects of tauroursodeoxycholic acid (TUDCA) to assess whether this acid may also have "protective" effects similar to those found with ursodeoxycholic acid (UDCA). We used a well-known amphibian model of gastric mucosa, and studied the effects of taurodeoxycholic acid (TDCA) on electrical transepi...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.110.3.197.8295
更新日期:2002-07-01 00:00:00
abstract::Pancreatic beta-cell mass expands through beta-cell proliferation and neogenesis while it decreases mainly via apoptosis. The loss of balance between beta-cell death and regeneration leads to a reduction of beta-cell functional mass, thus contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). The pathoge...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2013.795175
更新日期:2013-10-01 00:00:00
abstract::Serum uric acid is associated with an increased risk of hypertension, cardiovascular disease and chronic kidney disease. Hyperuricemia raises the risk of insulin resistance and metabolic syndrome including diabetes. Aim: To find the association between purine metabolites and diabetic complications in rats. Materials a...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1663219
更新日期:2019-09-13 00:00:00
abstract::Aim: This study tested the hypothesis that folic acid (FA) modulates biogenic amines and protects the brain against oxidative stress induced by 3-nitropropionic acid (3NPA).Methods: Male Wistar rats received (groups of six) for 5 d: FA (50 mg/kg); 3NPA (10 mg/kg); or FA +3NPA. At last day, rats were sacrificed, and th...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1484771
更新日期:2020-02-01 00:00:00
abstract::This study aimed to investigate the roles of RPSAP52 in renal failure. Our results showed that RPSAP52 was upregulated in plasma of renal failure patients in comparison to healthy controls. Dual luciferase reporter assay showed that RPSAP52 could interact with miR-423-5p, while overexpression of RPSAP52 and miR-423-5p...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1750657
更新日期:2020-04-17 00:00:00
abstract:OBJECTIVES:Examine the diagnostic role of serum exosomal RAB27A mRNA in lung cancer and evaluate the relation of LncRNAs to lung cancer in association to RAB27A mRNA in Egyptian population. METHODS:Exosomal RNA-based biomarkers RAB27A mRNA and Lnc-RNA-RP11-510M2.10 were selected based on bioinformatic methods, followe...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1778036
更新日期:2020-07-13 00:00:00
abstract::Phospholipid fatty acid composition and bilirubin UDP-glucuronyltransferase activity from liver microsomal membrane were studied in normal and in bile duct ligated rats. Incubation of normal microsomes with 15 microM bilirubin (considered as physiological concentration) yielded 60% bilirubin diglucuronide; in 2 days p...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813459509047136
更新日期:1995-08-01 00:00:00
abstract::Autophagy is an important life phenomenon in eukaryotic cells. Its main role is to remove and degrade its damaged organelles and excess biological macromolecules, and use degradation products to provide energy and rebuild the cell structure, playing an important role in maintaining cell homeostasis and cell life activ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1675714
更新日期:2019-10-09 00:00:00
abstract::The aim of this study was to examine (i) the effects of a severe interval training period on oxygen pulse kinetics (O2-p, the ratio between VO2 and heart rate), and (ii) to study the consequences of these effects on the variation of performance (time to exhaustion) during severe runs. Seven athletes were tested before...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.111.3.202.23455
更新日期:2003-07-01 00:00:00
abstract::Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an an...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1444059
更新日期:2019-05-01 00:00:00
abstract::Cytotoxic effects, including oxidative stress, of low linear energy transfer (LET)-ionizing radiation are often underestimated and studies of their mechanisms using cell culture models are widely conducted with cells cultivated at atmospheric oxygen that does not match its physiological levels in body tissues. Also, c...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2016.1218518
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of biochemical parameters, BMI and blood pressure with age, gender and ethnicity of Trinidadian type 2-diabetic subjects. METHODS:A retrospective case control study comprised of 1794 patient (740 males and 1054 females). RESULTS:The correlation was found for lipid profile with ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2011.613482
更新日期:2012-02-01 00:00:00
abstract::The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by t...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1517181
更新日期:2020-07-01 00:00:00
abstract::The glucose-fatty acid cycle as proposed four decades ago by Randle suggests that insulin resistance develops in consequence of alterations of the metabolic pressure of lipids. The more recently published 'hexosamine pathway theory' and the 'malonyl-CoA hypothesis' depict insulin resistance as a consequence of an imba...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.109.1.38.4284
更新日期:2001-02-01 00:00:00
abstract::Objective, materials and methods: The aim of this cross-sectional study with a consecutive enrolment was to analyse the role of high sensitive C-reactive protein (hs-CRP) measurement in similarly obese patients with and without the metabolic syndrome (MS). Results: In total, 589 obese patients were screened, of whom 1...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1434207
更新日期:2019-02-01 00:00:00
abstract::The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric ac...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2017.1395889
更新日期:2018-07-01 00:00:00
abstract:CONTEXT:Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE:This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS:Th...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2017.1347689
更新日期:2017-12-01 00:00:00
abstract::The effect of underfeeding over glucose metabolism in uteri isolated from ovariectomized and non-ovariectomized rats subjected to a restricted diet for 25 days (50% of the normal food intake), was studied. Underfeeding decreases (14)CO(2) formation from U(14) C-glucose in intact animal uteri. While in ovariectomized r...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.108.5.422.4295
更新日期:2000-12-01 00:00:00
abstract::Pulmonary ischemia-reperfusion (IR) injury may result from trauma, atherosclerosis, pulmonary embolism, pulmonary thrombosis and surgical procedures such as cardiopulmonary bypass and lung transplantation. IR injury induces oxidative stress characterized by formation of reactive oxygen (ROS) and reactive nitrogen spec...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1080/13813450601118976
更新日期:2007-02-01 00:00:00