Abstract:
:Aim: This study tested the hypothesis that folic acid (FA) modulates biogenic amines and protects the brain against oxidative stress induced by 3-nitropropionic acid (3NPA).Methods: Male Wistar rats received (groups of six) for 5 d: FA (50 mg/kg); 3NPA (10 mg/kg); or FA +3NPA. At last day, rats were sacrificed, and their brain was obtained to measure the levels of dopamine, 5-hydroxiindol acetic acid (5-HIAA). Reduced glutathione (GSH), total ATPase, H2O2 and lipid peroxidation were measured.Results: GSH increased significantly in cortex of rats treated with FA. ATPase increased significantly in cerebellum/medulla oblongata and decreased in cortex of animal treated with 3NPA. 5-HIAA increased in striatum of rats that received 3NPA alone or combined with FA.Conclusion: 3NPA generates free radicals such effect can be counteracted with FA administration since this folate increases antioxidant capacity and modulates biogenic amines.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Calderón Guzmán D,Osnaya Brizuela N,Ortiz Herrera M,Juárez Olguín H,Valenzuela Peraza A,Hernández García E,Barragán Mejía Gdoi
10.1080/13813455.2018.1484771subject
Has Abstractpub_date
2020-02-01 00:00:00pages
1-6issue
1eissn
1381-3455issn
1744-4160journal_volume
126pub_type
杂志文章abstract::The current in-vivo study was premeditated to uncover the protective role of ezetimibe (EZ) against advanced glycation endproducts (AGEs)-related pathologies in experimental diabetes. Our results showed that EZ markedly improved the altered biochemical markers of diabetes mellitus (DM) (FBG, HbA1c, insulin, microalbum...
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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更新日期:2019-09-09 00:00:00
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更新日期:2018-12-01 00:00:00
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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更新日期:2002-07-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
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更新日期:2019-06-07 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00