Differential effect of high-fat, high-sucrose and combined high-fat/high-sucrose diets consumption on fat accumulation, serum leptin and cardiac hypertrophy in rats.

Abstract:

:The consumption of high calorie-content diets is the first cause of obesity, probably the main health issue worldwide; however, the experimental evidences for evaluating the differential metabolic modifications of high-sucrose or high-fat diets are scare. We evaluated the metabolic outcomes of the obesity induced by the chronic consumption of high-sucrose (HS), high-fat (HF) or combined diets (HSHF), among the effect on the development of cardiac hypertrophy in Wistar rats. Rats from the HS, HF, and HSHS groups developed moderate obesity. Only the HS group showed increased triglycerides levels after four months. Increased leptin levels were observed in HS and HF groups without changes on cardiac hypertrophy; on the opposing, HSHF group presented hypertrophy without the changes in serum leptin. The three experimental groups showed a decreased expression of leptin receptors ObR-b. In our results, the kind of diet for the induction of obesity is relevant for the outcome of the pathological profile.

journal_name

Arch Physiol Biochem

authors

Gómez-Crisóstomo NP,De la Cruz-Hernández EN,Méndez Méndez ER,Hernández-Landero MF,Camacho Liévano JU,Martínez-Abundis E

doi

10.1080/13813455.2018.1517181

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

258-263

issue

3

eissn

1381-3455

issn

1744-4160

journal_volume

126

pub_type

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