Purine metabolites can indicate diabetes progression.

Abstract:

:Serum uric acid is associated with an increased risk of hypertension, cardiovascular disease and chronic kidney disease. Hyperuricemia raises the risk of insulin resistance and metabolic syndrome including diabetes. Aim: To find the association between purine metabolites and diabetic complications in rats. Materials and methods: Alloxan was administered to induce diabetes in rats. After 30 days, the levels of uric acid, inosine, xanthine, hypoxanthine and AMP were assessed in both plasma and liver tissues using HPLC technique. Results: A significant increase in xanthine, hypoxanthine, AMP levels (p < .001 and t-value 2.78) and inosine in plasma and liver tissues (p < .05 and t-value 2.11) with a concomitant increase in uric acid levels (p < .001 and t-value 2.80) was observed in diabetic group. Conclusion: Purine metabolites like uric acid and other intermediate products of purine metabolism are increased in diabetes. These results can be used in addition or separately in evaluating the progression of diabetes.

journal_name

Arch Physiol Biochem

authors

Varadaiah YGC,Sivanesan S,Nayak SB,Thirumalarao KR

doi

10.1080/13813455.2019.1663219

subject

Has Abstract

pub_date

2019-09-13 00:00:00

pages

1-5

eissn

1381-3455

issn

1744-4160

pub_type

杂志文章
  • Influence of ovariectomy and estradiol treatment on calcium homeostasis during aging in rats.

    abstract::Study was carried out an Wistar female rats to evaluate the consequences of ovariectomy and 17 beta-estradiol substitutive treatment during aging on bone. Ca metabolism and calciotropic hormones. Three groups of fifteen rats, mature, old and senescent (4-, 10-, and 28 month-old) female were fed a diet (6 g/100 g BW/da...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.5.435.3292

    authors: Gaumet N,Seibel MJ,Coxam V,Davicco MJ,Lebecque P,Barlet JP

    更新日期:1997-09-01 00:00:00

  • Cardiopreventive effects of camel milk against carbon tetrachloride induced oxidative stress, biochemical and histological alterations in mice.

    abstract::The present study was designed to examine the preventive effects of camel milk (CM) against the toxic effects of acute exposure to carbon tetrachloride (CCl4) on the heart tissue of mice. Administration of a single dose of CCl4 caused cardio toxicity as monitored by an increase in lipid peroxidation (thiobarbituric ac...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1395889

    authors: Hamed H,Gargouri M,Bellassoued K,Ghannoudi Z,Elfeki A,Gargouri A

    更新日期:2018-07-01 00:00:00

  • Cytoprotective effects of essential oil of Pinus halepensis L. against aspirin-induced toxicity in IEC-6 cells.

    abstract:CONTEXT:Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE:This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS:Th...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1347689

    authors: Bouzenna H,Hfaiedh N,Bouaziz M,Giroux-Metges MA,Elfeki A,Talarmin H

    更新日期:2017-12-01 00:00:00

  • 4-Phenylbutyric acid and rapamycin improved diabetic status in high fat diet/streptozotocin-induced type 2 diabetes through activation of autophagy.

    abstract::An accumulating body of evidence supports the role of autophagy in the pathophysiology of T2DM. Also, abnormal endoplasmic reticulum (ER) stress response that has been implicated as a cause of insulin resistance (IR) could also be affected by the autophagic status in β-cells. The present study was designed to investig...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1628069

    authors: Gadallah SH,Ghanem HM,Abdel-Ghaffar A,Metwaly FG,Hanafy LK,Ahmed EK

    更新日期:2019-06-19 00:00:00

  • Age-dependent detection of erythrocytes glucose-6-phosphate dehydrogenase and its correlation with oxidative stress.

    abstract:CONTEXT:Glucose-6-phosphate dehydrogenase (G6PD) is an important enzyme of hexose monophosphate shunt, involved in the biosynthesis of reduced nicotinamide adenine dinucleotide phosphate hydrogen (NADPH). OBJECTIVE:This study was designed to investigate age-dependent changes in human erythrocyte G6PD activity. The G6P...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2015.1136648

    authors: Maurya PK,Kumar P,Chandra P

    更新日期:2016-01-01 00:00:00

  • Renal excretion and saline intake during post-stress immobilization period in rats.

    abstract::An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/1381345520000710831zft268

    authors: Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

    更新日期:2000-07-01 00:00:00

  • High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats.

    abstract::Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.Met...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1511599

    authors: Khakdan S,Delfan M,Heydarpour Meymeh M,Kazerouni F,Ghaedi H,Shanaki M,Kalaki-Jouybari F,Gorgani-Firuzjaee S,Rahimipour A

    更新日期:2020-07-01 00:00:00

  • Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.

    abstract:OBJECTIVE:The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homoeostasis, as well as on the underlying inflammatory mechanisms, were examined in high-fat and high-sucrose (HF/HS) diet-induced obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1148053

    authors: Harzallah A,Hammami M,Kępczyńska MA,Hislop DC,Arch JR,Cawthorne MA,Zaibi MS

    更新日期:2016-01-01 00:00:00

  • Exercise training decreases oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension.

    abstract::The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session,...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1769679

    authors: Becker CU,Sartório CL,Campos-Carraro C,Siqueira R,Colombo R,Zimmer A,Belló-Klein A

    更新日期:2020-05-25 00:00:00

  • Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway.

    abstract:OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1874017

    authors: A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi S

    更新日期:2021-01-20 00:00:00

  • Use of a simple fractionation method to evaluate binding, internalization and intracellular distribution of oligonucleotides in vascular smooth muscle cells.

    abstract::Antisense oligonucleotides (ODN) are potent molecules that could be used to inhibit the synthesis of a protein specifically if delivered to the appropriate compartments (cytoplasm and nucleus) of the cell under study. We present here a simple method providing access to the fractions of internalized ODN available in th...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.111.3.265.23465

    authors: Eboue D,Auger R,Angiari C,Le Doan T,Tenu JP

    更新日期:2003-07-01 00:00:00

  • New insights into the in vitro, in situ and in vivo antihyperglycemic mechanisms of gallic acid and p-coumaric acid.

    abstract::Objective: To explore the probable in vitro, in situ and in vivo mechanisms of gallic acid (GA) and p-coumaric acid (PCA) as anti-hyperglycemic agents.Animals and methods: Male albino rats were allocated into four groups, group1 was used as normal control. Group 2 was established as a diabetic control and group3 and 4...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1762659

    authors: Abdel-Moneim A,Abd El-Twab SM,Yousef AI,Ashour MB,Reheim ESA,Hamed MAA

    更新日期:2020-05-13 00:00:00

  • Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat.

    abstract::Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1668018

    authors: Atila Uslu G,Uslu H

    更新日期:2019-09-23 00:00:00

  • Involvement of cellular calcium in exocrine pancreatic insufficiency during streptozotocin-induced diabetes mellitus.

    abstract::This study investigates the effects of the islet hormones insulin (Ins), glucagon (Glu), and somatostatin (Som) with nerve stimulation (EFS) acetylcholine (ACh) and cholecytokinin-octapeptide (CCK-8) on amylase secretion and intracellular free calcium concentration [Ca(2+)](i) in the pancreas of age-matched control an...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.109.3.252.11585

    authors: Singh J,Yago MD,Adeghate E

    更新日期:2001-07-01 00:00:00

  • Effects of insulin-like growth factor binding proteins in bone -- a matter of cell and site.

    abstract::The actions of the insulin-like growth factor (IGF)-system are controlled by six IGF-binding proteins (IGFBPs). The IGFBPs are thought to affect local effects of IGF-I and IGF-II due to higher affinity if compared to IGF-I receptors and due to cell-type specific IGFBP expression patterns. It was found in IGFBP knockou...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450701531193

    authors: Hoeflich A,Götz W,Lichanska AM,Bielohuby M,Tönshoff B,Kiepe D

    更新日期:2007-06-01 00:00:00

  • Nutrition in the management of type 2 diabetes mellitus: review.

    abstract::Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. In recent years, numerous effective T2DM intervention regimens have been developed, with promising results. However, these regimens are not usually economically available, and they are not well tolerate...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1657899

    authors: El-Tantawy WH

    更新日期:2019-09-02 00:00:00

  • Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine.

    abstract::Dopamine (DA) is thought to modulate the transduction of the hypoxic stimulus by the glomus cell in the carotid body (CB). The hypothesis tested here is that presynaptic DA D2 receptors (D2's) located on the type 1 cell function as autoreceptors to control DA release and/or synthesis. The aim of the study was to compa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.1.3.13145

    authors: Basson H,Bairam A,Cottet-Emard JM,Pequignot JM,Marchal F

    更新日期:1997-02-01 00:00:00

  • Insulin-status-dependent modulation of FoF1 ATPase activity in rat kidney mitochondria.

    abstract::The early and late effects of alloxan-diabetes and insulin treatment on kinetic properties of mitochondrial FoF1 ATPase were examined. Diabetic state resulted in significant decrease in the activity while insulin treatment caused hyper-stimulation. In control animals the enzyme activity resolved in three kinetic compo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813450600935206

    authors: Patel SP,Katyare SS

    更新日期:2006-07-01 00:00:00

  • Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women.

    abstract::The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1171365

    authors: Çelik F,Belviranli M,Okudan N

    更新日期:2016-10-01 00:00:00

  • Effect of carnosine on erythrocyte deformability in diabetic rats.

    abstract::It is known that oxidative stress plays an important role in the chronic complications of diabetes. Lipid peroxidation is one of the consequences of oxidative stress. Erythrocyte deformability abilities are reduced as a result of lipid peroxidation. Conversely, a decrease nitric oxide (NO) production seems to be respo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2012.714790

    authors: Yapislar H,Aydogan S

    更新日期:2012-12-01 00:00:00

  • Perceptions of Caribbean type 2 diabetes patients on self-monitoring of blood glucose.

    abstract:CONTEXT:The views of type 2 diabetes (T2DM) patients have not been considered in the debate on the role of self-monitoring of blood glucose (SMBG) in the management of T2DM. OBJECTIVE:To assess the views of T2DM patients on SMBG. METHODS:Two previously trained research assistants used a structured pre-tested question...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.625950

    authors: Ezenwaka CE,Olukoga A,Onuoha P,Worrell R,Skinner T,Mayers H,Martin E,Phillip C

    更新日期:2012-02-01 00:00:00

  • Biomechanical events in the time to exhaustion at maximum aerobic speed.

    abstract::Recent studies reported good intra-individual reproducibility, but great inter-individual variation in a sample of elite athletes, in time to exhaustion (tlim) at the maximal aerobic speed (MAS: the lowest speed that elicits VO2max in an incremental treadmill test). The purpose of the present study was, on the one han...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.6.583.3272

    authors: Gazeau F,Koralsztein JP,Billat V

    更新日期:1997-10-01 00:00:00

  • Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions.

    abstract::Pulmonary ischemia-reperfusion (IR) injury may result from trauma, atherosclerosis, pulmonary embolism, pulmonary thrombosis and surgical procedures such as cardiopulmonary bypass and lung transplantation. IR injury induces oxidative stress characterized by formation of reactive oxygen (ROS) and reactive nitrogen spec...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450601118976

    authors: Ovechkin AV,Lominadze D,Sedoris KC,Robinson TW,Tyagi SC,Roberts AM

    更新日期:2007-02-01 00:00:00

  • A comprehensive systematic review of the effectiveness of Akkermansia muciniphila, a member of the gut microbiome, for the management of obesity and associated metabolic disorders.

    abstract:AIMS AND BACKGROUND:Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, Akkermansia muciniphila has been proposed as a promising microbe to manage obesity. In the present systematic review, we evalua...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1871760

    authors: Roshanravan N,Bastani S,Tutunchi H,Kafil B,Nikpayam O,Mesri Alamdari N,Hadi A,Sotoudeh S,Ghaffari S,Ostadrahimi A

    更新日期:2021-01-15 00:00:00

  • Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity.

    abstract::Context: The anti-diabetic medicine metformin has been reported as an anti-ageing drug candidate as it mimics the benefits of caloric restriction and reduces ageing-related oxidative stress in various experimental organisms. Objective: We investigated the possible anti-oxidative role of metformin against rotenone-indu...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1620288

    authors: Tripathi SS,Singh AK,Akhtar F,Chaudhary A,Rizvi SI

    更新日期:2019-06-01 00:00:00

  • Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.

    abstract:CONTEXT:Vanillin is known to possess important antioxidant activity. OBJECTIVE:The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice. MATERIAL AND METHODS:Mice were exposed during 15 days eith...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1283527

    authors: Ben Saad H,Kharrat N,Driss D,Gargouri M,Marrakchi R,Jammoussi K,Magné C,Boudawara T,Ellouz Chaabouni S,Zeghal KM,Hakim A,Ben Amara I

    更新日期:2017-07-01 00:00:00

  • Age-associated alteration of muscle oxygenation measured by near infrared spectroscopy during exercise.

    abstract::The influence of ageing on the capacity to increase muscle oxygen delivery during exercise is unclear. This was investigated by comparing the evolution of Near InfraRed Spectroscopy (NIRS) in 10 old (67 +/- 5 years, Old group) and 13 young subjects (27 +/- 4 years, Young group), during a progressive maximal exercise. ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.107.2.159.4343

    authors: Costes F,Denis C,Roche F,Prieur F,Enjolras F,Barthélémy JC

    更新日期:1999-04-01 00:00:00

  • Biochanin A, a soy isoflavone, diminishes insulin resistance by modulating insulin-signalling pathway in high-fat diet-induced diabetic mice.

    abstract:AIM:The objective of this study was to evaluate the probable mechanism of action of Biochanin A (BCA) on high-fat diet-induced insulin resistance mice. METHODS:Twenty-four male C57/BL/6J mice were divided into two and fed either control diet or a high fat-high diet (HFD). After 6 weeks, mice were grouped into: Control...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1820525

    authors: Arjunan S,Thangaiyan R,Balaraman D

    更新日期:2020-09-29 00:00:00

  • New lower cutoff for serum high sensitive C-reactive protein in obese women indicates the risk of metabolic syndrome.

    abstract::Objective, materials and methods: The aim of this cross-sectional study with a consecutive enrolment was to analyse the role of high sensitive C-reactive protein (hs-CRP) measurement in similarly obese patients with and without the metabolic syndrome (MS). Results: In total, 589 obese patients were screened, of whom 1...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1434207

    authors: Kucharska A,Sawicka-Gutaj N,Owecki M

    更新日期:2019-02-01 00:00:00

  • Relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes.

    abstract:OBJECTIVE:To assess the relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes. METHODS:Anthropometric and biochemical parameters were measured in 56 newly diagnosed type 2 diabetic men and in 56 age and body mass index (BMI) matched...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2012.715651

    authors: Sarkar PD,Choudhury AB

    更新日期:2012-12-01 00:00:00