Abstract:
:Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). After eight weeks of running, expression of miR-195 and myocardial function were evaluated.Results: HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with CET. Our results showed that HIIT compared with CET increases left ventricular ejection fraction (LVEF%) and fractional shortening (FS%).Conclusions: Our results indicated that exercise, especially HIIT is an appropriate strategy for reducing miR-195 and improving myocardial function in diabetic rats compared with CET.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Khakdan S,Delfan M,Heydarpour Meymeh M,Kazerouni F,Ghaedi H,Shanaki M,Kalaki-Jouybari F,Gorgani-Firuzjaee S,Rahimipour Adoi
10.1080/13813455.2018.1511599subject
Has Abstractpub_date
2020-07-01 00:00:00pages
250-257issue
3eissn
1381-3455issn
1744-4160journal_volume
126pub_type
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