Abstract:
:Ethanol-consumption impairs physiological-efficiency/endurance, expedites senescence. Impaired-regulations of steroids/biomolecules link these processes. Steroids are catabolized by cytosolic-sulfotransferases (SULTs). Ethanol-induction of eukaryotic-SULTs-expression is scanty. Plant (Brassica-napus) steroid-sulfotransferase; BNST3/BNST4 (gene/BNST) is highly ethanol-inducible (protein/mRNA). Resembling mammalian-SULTs catalytic-mechanism BNSTs show broad substrate-specificities (mammalian-steroids; estradiol/dehydroepiandrosterone/pregnanolone). Recently, ethanol-regulation of SULTs-expression is verified in rat liver/intestine/cultured human-hepatocarcinoma (Hep-G2) cells at enzyme-activity/protein-expression (Western-blot) level. Here, two week's ethanol ingestion by male rat significantly increased SULT2A1 in their liver/intestine (p < 0.05-p < 0.001) and phenol-sulfotransferase (SULT1A1) in intestine (p < 0.001) at enzyme-activity/protein levels. In human cells, ethanol significantly (2-fold) increased hSULT1A1/hSULT1E (2-3 fold) protein expressions paralleling their enzymatic-activities (p < 0.05-p < 0.01). The earlier finding of alcohol-association to the physiological impairment may be corroborated by our present findings. Inductions of SULT-expressions by ethanol have significant physiological/pharmacological consequences.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Maiti S,Chen Gdoi
10.3109/13813455.2014.992440subject
Has Abstractpub_date
2015-05-01 00:00:00pages
68-74issue
2eissn
1381-3455issn
1744-4160journal_volume
121pub_type
杂志文章abstract::Evidence is presented of a Mg2+ and Ca(2+)-activated ATPase at the surface of cultured rat glomerular mesangial cells. Substrate specificity was very low when different nucleoside-5'-triphosphates were examined. The apparent Km values were 0.46 and 0.32 mM for Mg(2+)-ATPase and Ca(2+)-ATPase, respectively. Inhibition ...
journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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doi:10.1080/13813455.2020.1739714
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journal_title:Archives of physiology and biochemistry
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doi:10.3109/13813455.2016.1148053
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2010.494670
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journal_title:Archives of physiology and biochemistry
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doi:10.1080/13813455.2017.1347689
更新日期:2017-12-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1484771
更新日期:2020-02-01 00:00:00
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doi:10.1080/13813455.2018.1479427
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.105.2.158.12924
更新日期:1997-04-01 00:00:00
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doi:10.1080/13813455.2020.1771378
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1778037
更新日期:2020-06-17 00:00:00
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journal_title:Archives of physiology and biochemistry
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doi:10.1080/13813455.2019.1675714
更新日期:2019-10-09 00:00:00
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journal_title:Archives of physiology and biochemistry
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doi:10.1080/13813455.2020.1716019
更新日期:2020-01-29 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2013.812664
更新日期:2013-10-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2021.1874996
更新日期:2021-01-29 00:00:00
abstract::Background: Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA.Subjects and methods: 100 RA patients and 100 healthy individuals were enrolled in the study. Quantitative PCR was used for expression analysis ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1784951
更新日期:2020-07-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2013.795175
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journal_title:Archives of physiology and biochemistry
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doi:10.1076/apab.104.2.239.12876
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2016.1151892
更新日期:2016-07-01 00:00:00
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pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1662453
更新日期:2019-09-09 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2018.1437751
更新日期:2019-05-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1826529
更新日期:2020-10-05 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813450903428086
更新日期:2009-12-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2018-12-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2011.557386
更新日期:2011-07-01 00:00:00
abstract::The effectiveness of betulinic acid (B) and PLGA loaded nanoparticles of B (Bnp) against hepatocellular carcinoma (HCC) was established and reported earlier. In continuation of our previous report, the present study described the molecular mechanisms of their antineoplastic responses. In this context, the antineoplast...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1733024
更新日期:2020-03-06 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1623820
更新日期:2019-06-19 00:00:00