Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.

Abstract:

CONTEXT:Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear. OBJECTIVE:To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway. MATERIALS AND METHODS:Rats were divided into control, sham, sham + ghrelin, myocardial infarction (MI), and MI + ghrelin groups. Ghrelin (100 µg/kg) was administered for 21 days, starting one-day post-MI. RESULTS:Ghrelin enhanced cardiac contractility and the activities of antioxidant enzymes, lowered serum levels of enzyme markers of cardiac dysfunction, and lowered inflammatory mediator levels. Ghrelin increased levels of phospho-Raf-1 (Ser338), phospho-MEK1/2 (Ser217/221), phospho-ERK1/2 (Thr202/Tyr204), and of their downstream target p-BAD (Ser112) and inhibited the cleavage of caspase-3. Concomitantly, ghrelin prevented the increases in the levels of fibrotic markers, including α-smooth muscle actin (α-SMA), metalloproteinase-9 (MPP-9), and type III collagen. CONCLUSION:Post-MI in rats, ghrelin stimulated Raf-1-MEK1/2-ERK1/2-BAD signalling in the LV infarct areas, accounting for its anti-apoptotic effect, enhancing cardiac function, and inhibiting cardiac fibrosis during cardiac remodelling.

journal_name

Arch Physiol Biochem

authors

Eid RA,Alkhateeb MA,Al-Shraim M,Eleawa SM,Shatoor AS,El-Kott AF,Zaki MSA,Shatoor KA,Bin-Jaliah I,Al-Hashem FH

doi

10.1080/13813455.2018.1437751

subject

Has Abstract

pub_date

2019-05-01 00:00:00

pages

93-103

issue

2

eissn

1381-3455

issn

1744-4160

journal_volume

125

pub_type

杂志文章
  • Upregulation of the transport system for TNFalpha at the blood-brain barrier.

    abstract::The transport system for the cytokine tumor necrosis factor-alpha (TNFalpha) at the blood-brain barrier (BBB) enables an enhanced yet saturable entry of TNFalpha from blood to the CNS. This review focuses on the selective upregulation of the transport system for TNFalpha at the BBB that is specific for type of patholo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.109.4.350.4238

    authors: Pan W,Kastin AJ

    更新日期:2001-10-01 00:00:00

  • Effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters and serum oxidative stress markers in fructose-induced diabetic Wistar rats.

    abstract::Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1716017

    authors: Bassey IE,Ikpi DE,Isong IKP,Akpan UO,Onyeukwu CC,Nwankwo NP,Udofia IG

    更新日期:2020-01-25 00:00:00

  • Lipid modifications of microsomes isolated from villus and crypt zones of bovine intestinal mucosa: relationship with fatty acid binding protein.

    abstract::The present studies were conducted to examine the fatty acid composition of microsomal lipids of bovine small intestine. Microsomes and cytosol were isolated from mucosal scrapings enriched with villus and crypts cells, and the following studies were conducted to: 1) analyse fatty acids from microsomal lipids; 2) inco...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.1.86.13147

    authors: Furlan L,Catala A

    更新日期:1997-02-01 00:00:00

  • Nutrition in the management of type 2 diabetes mellitus: review.

    abstract::Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. In recent years, numerous effective T2DM intervention regimens have been developed, with promising results. However, these regimens are not usually economically available, and they are not well tolerate...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1657899

    authors: El-Tantawy WH

    更新日期:2019-09-02 00:00:00

  • Modulatory effect of isopulegol on hepatic key enzymes of glucose metabolism in high-fat diet/streptozotocin-induced diabetic rats.

    abstract::To investigate the antidiabetic effect of isopulegol in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic rats. Animals were made diabetic by feeding HFD for 4 weeks followed by single intraperitoneal injection of STZ (35 mg/kg b.w.; 0.1 M citrate buffer; pH 4.0). Plasma insulin, haemoglobin and glycogen conte...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1638415

    authors: Kalaivani K,Sankaranarayanan C

    更新日期:2019-07-10 00:00:00

  • Arecoline inhibits pineal-testis function in experimentally induced hypothyroid rats.

    abstract::Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulat...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1486428

    authors: Saha I,Chakraborty SB,Chatterjee A,Pradhan D,Chatterji U,Maiti BR

    更新日期:2020-02-01 00:00:00

  • Lung ischemia-reperfusion injury: implications of oxidative stress and platelet-arteriolar wall interactions.

    abstract::Pulmonary ischemia-reperfusion (IR) injury may result from trauma, atherosclerosis, pulmonary embolism, pulmonary thrombosis and surgical procedures such as cardiopulmonary bypass and lung transplantation. IR injury induces oxidative stress characterized by formation of reactive oxygen (ROS) and reactive nitrogen spec...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450601118976

    authors: Ovechkin AV,Lominadze D,Sedoris KC,Robinson TW,Tyagi SC,Roberts AM

    更新日期:2007-02-01 00:00:00

  • Effect of curcuma on zinc, lipid profile and antioxidants levels in blood and tissue of streptozotocin-induced diabetic rats fed zinc deficiency diet.

    abstract::Due to the importance of zinc as an antioxidant and its crucial role in insulin synthesis, its deficiency may affect adversely diabetic state. So, this study aimed to modulate these effects using Curcuma longa as natural antioxidant. Rats were divided into four groups: two groups fed a zinc sufficient diet one non-dia...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1623820

    authors: Tebboub I,Kechrid Z

    更新日期:2019-06-19 00:00:00

  • Angiotensin II-induced growth effects in vascular smooth muscle in cell culture and in the aortic tunica media in organ culture.

    abstract::Several different studies have investigated the growth effects of angiotensin II on vascular smooth muscle cells in culture. However, smooth muscle cells change their phenotype when placed in culture. The objective of the present study was to investigate the effects of angiotensin II on (3)H-thymidine and (3)H-proline...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.109.5.404.11827

    authors: Mangiarua EI,Galagedera NJ,Eastham LL

    更新日期:2001-12-01 00:00:00

  • Diagnostic and prognostic value of new bioscore in critically ill septic patients.

    abstract::Objective: To evaluate the diagnostic and prognostic value of biomarkers and new bioscore in septic patients in intensive care unit (ICU).Materials and methods: A study was conducted on septic and non-septic patients in ICU. Diagnostic and prognostic values of C-reactive protein (CRP), procalcitonin (PCT), Sequential ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1677720

    authors: Sen P,Demirdal T,Nemli SA,Sencan A

    更新日期:2019-11-05 00:00:00

  • Molecular targets for steroids in airway vascular smooth muscle.

    abstract::The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Usi...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331337559

    authors: Horvath G,Wanner A

    更新日期:2003-10-01 00:00:00

  • Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals.

    abstract::Aim: This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods: Male infertility was induced in rat by intrape...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1645698

    authors: Ghareeb DA,Abd-Elgwad A,El-Guindy N,Yacout G,Zaatout HH

    更新日期:2019-07-31 00:00:00

  • Striate, extrastriate and collicular processing of spatial disparity cues.

    abstract::The spatial disparity sensitivity of single units in the primary visual cortex (17-18 border), in extrastriate area 19 and in the superficial layers of the superior colliculus of the cat brain were compared in the present study. Unit recordings were performed in paralyzed and anesthetized animals. Centrally located re...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.106.3.236.4376

    authors: Bacon BA,Lepore F,Guillemot JP

    更新日期:1998-07-01 00:00:00

  • Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats.

    abstract:CONTEXT:Metabolic syndrome (MetS) is a clustering of several physiological alterations. OBJECTIVE:This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. MATERIALS AND METHODS:We developed a MetS rodent model using high-sugar and high-fat diet. RESULTS:MetS rats showed se...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1812665

    authors: Rahali D,Dallagi Y,Hupkens E,Veegh G,Mc Entee K,Asmi ME,El Fazaa S,El Golli N

    更新日期:2020-09-04 00:00:00

  • Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.

    abstract:OBJECTIVE:The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homoeostasis, as well as on the underlying inflammatory mechanisms, were examined in high-fat and high-sucrose (HF/HS) diet-induced obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1148053

    authors: Harzallah A,Hammami M,Kępczyńska MA,Hislop DC,Arch JR,Cawthorne MA,Zaibi MS

    更新日期:2016-01-01 00:00:00

  • A comparative study of the prevalence of the metabolic syndrome and its components in type 2 diabetic patients in two Caribbean islands using the new International Diabetes Federation definition.

    abstract:BACKGROUND AND AIM:Tobago and Trinidad are two Caribbean islands with distinct genetic background and lifestyles; while Tobago is serene and a tourist centre, Trinidad is characterized by a hustling and bustling lifestyle. The study was aimed at determining and comparing the prevalence of the metabolic syndrome (MetS) ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813450701475201

    authors: Ezenwaka CE,Nwagbara E,Seales D,Okali F,Hussaini S,Raja B,Wheeler V,Sell H,Avci H,Eckel J

    更新日期:2007-10-01 00:00:00

  • Association of hyperglycaemia and hyperlipidaemia with cognitive dysfunction in schizophrenia spectrum disorder.

    abstract::The objective of the study was to investigate the association of blood glucose and lipid profile parameters with cognitive impairment in schizophrenia. A total of 200 schizophrenia patients and 169 controls were enrolled in the study. Blood glucose and lipid profile were estimated in all the subjects. Cognition was as...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1839500

    authors: Nandeesha H,Keshri N,Rajappa M,Menon V

    更新日期:2020-11-03 00:00:00

  • Sputum adenosine deaminase and alkaline phosphatase activity in pulmonary tuberculosis.

    abstract:OBJECTIVE:The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis. METHODS:This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum. RESULTS:The...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.645545

    authors: Jadhav AA,Jain A

    更新日期:2012-02-01 00:00:00

  • Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress.

    abstract::Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers.Materials and method...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1771378

    authors: Ebrahim HA,Alzamil NM,Al-Ani B,Haidara MA,Kamar SS,Dawood AF

    更新日期:2020-06-04 00:00:00

  • Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods.

    abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.104.6.752.12911

    authors: Hess GP

    更新日期:1996-10-01 00:00:00

  • Spirulina effect on modulation of toxins provided by food, impact on hepatic and renal functions.

    abstract::Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an an...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1444059

    authors: Ould Amara-Leffad L,Ramdane H,Nekhoul K,Ouznadji A,Koceir EA

    更新日期:2019-05-01 00:00:00

  • Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat.

    abstract::Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1668018

    authors: Atila Uslu G,Uslu H

    更新日期:2019-09-23 00:00:00

  • Age-associated alteration of muscle oxygenation measured by near infrared spectroscopy during exercise.

    abstract::The influence of ageing on the capacity to increase muscle oxygen delivery during exercise is unclear. This was investigated by comparing the evolution of Near InfraRed Spectroscopy (NIRS) in 10 old (67 +/- 5 years, Old group) and 13 young subjects (27 +/- 4 years, Young group), during a progressive maximal exercise. ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.107.2.159.4343

    authors: Costes F,Denis C,Roche F,Prieur F,Enjolras F,Barthélémy JC

    更新日期:1999-04-01 00:00:00

  • Renal excretion and saline intake during post-stress immobilization period in rats.

    abstract::An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/1381345520000710831zft268

    authors: Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

    更新日期:2000-07-01 00:00:00

  • Enhanced luminescence study of liver homogenate response to oxidative stress.

    abstract::An enhanced luminescence technique was used to monitor the response of liver homogenates stressed with sodium perborate. Rat liver homogenates were subjected to oxidative stress with sodium perborate, and the light signals, generated by a suitable system, containing luminol and compounds producing enhancement of light...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813459508996132

    authors: Di Meo S,Venditti P,Piro MC,De Leo T

    更新日期:1995-05-01 00:00:00

  • Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats.

    abstract::This study investigated the effects of garlic on anxiety- and depression-related behaviors and brain oxidative markers in streptozotocin (STZ)-induced diabetes in rats. Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8/group): control, diabetic + saline, diabetic + garlic, diabetic...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1494746

    authors: Rahmani G,Farajdokht F,Mohaddes G,Babri S,Ebrahimi V,Ebrahimi H

    更新日期:2020-05-01 00:00:00

  • Quantitative electroencephalographic changes due to middle cerebral artery occlusion by endothelin 1 in conscious rats.

    abstract::The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a pathologically low level upon intracerebral injection adjacent to the MCA. This reduction manifests itself as an ischemic infarct, that is fully de...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.106.5.384.4362

    authors: Moyanova S,Kortenska L,Kirov R,Iliev I

    更新日期:1998-12-01 00:00:00

  • The interrelationship between inflammatory cytokines and skeletal muscle decay from the viewpoint of circadian rhythms.

    abstract::Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS in...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1782435

    authors: Luo X,Yang X,Yang Y,Li H,Cui H,Cao X

    更新日期:2020-07-01 00:00:00

  • Decreased level of plasma nesfatin-1 in rats exposed to cell phone radiation is correlated with thyroid dysfunction, oxidative stress, and apoptosis.

    abstract::Context: Exposure to Electomagnetic radiation fields of cell phones causes thyroid dysfunction and a previous study revealed that nesfatin-1 may affect functions of the thyroid gland.Objective: To study the role of nesfatin-1 on functions of rat's thyroid gland exposed to EMRF.Materials and methods: Thirty adult male ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1778037

    authors: Hussien NI,Mousa AM,Shoman AA

    更新日期:2020-06-17 00:00:00

  • Nandrolone modulates the non-opioid and opioid analgesia and tolerance/dependence: role of sexual dimorphism.

    abstract::The aim of this investigation was to study the effect of the doping steroid nandrolone on metamizol and morphine-induced analgesia and tolerance/dependence in rats. Nandrolone per se did not change the basal nociceptive thresholds in both sexes. It diminished the analgesic effect of metamizol in females, revealed by t...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331342283

    authors: Philipova T,Ivanova T,Pavlova E,Kasakov L,Vlaskovska M

    更新日期:2003-12-01 00:00:00