Comparison of potential preventive effects of pomegranate flower, peel and seed oil on insulin resistance and inflammation in high-fat and high-sucrose diet-induced obesity mice model.

Abstract:

OBJECTIVE:The potentially beneficial effects of pomegranate peel (PPE), flower (PFE) and seed oil (PSO) extracts, in comparison with rosiglitazone, on adiposity, lipid profile, glucose homoeostasis, as well as on the underlying inflammatory mechanisms, were examined in high-fat and high-sucrose (HF/HS) diet-induced obese (DIO) mice. MEASUREMENTS:Body weight, body fat, energy expenditure, food and liquid intake, blood glucose, and plasma levels of insulin, lipids and cytokines were measured. RESULTS:After two weeks, PSO (2 ml/kg/day) and rosiglitazone (3 mg/kg/day) had not improved glucose intolerance. After 4 weeks, both treatments significantly reduced fasting blood glucose and an insulin tolerance test showed that they also improved insulin sensitivity. Treatment with PPE, PFE and PSO, reduced the plasma levels of the pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α), and PFE increased the level of the anti-inflammatory cytokine interleukin-10 (IL-10). CONCLUSION:PPE, PFE and PSO have anti-inflammatory properties. PSO also improved insulin sensitivity.

journal_name

Arch Physiol Biochem

authors

Harzallah A,Hammami M,Kępczyńska MA,Hislop DC,Arch JR,Cawthorne MA,Zaibi MS

doi

10.3109/13813455.2016.1148053

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

75-87

issue

2

eissn

1381-3455

issn

1744-4160

journal_volume

122

pub_type

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