Circulating mir-21 and mir-146a are associated with increased cytokines and CD36 in Algerian obese male participants.

Abstract:

:Background: The microRNAs have come up as crucial mediators of energy balance and metabolic control. CD36 is potential biomarker of obesity and metabolic syndrome. This study investigates the concentration of miR-146a and miR-21 and CD 36 in blood samples of obese and healthy young participants. We assessed the association of mir-146a and mir-21 with inflammatory states in Algerian young participants.Methods: Our study included male obese, without co-morbidities (n = 29), and healthy participants (n = 13). miRNA and CD36 expression was measured by real-time RT-PCR, respectively, in serum and blood.Results: miR-146a and miR-21 concentrations were significantly decreased; however, CD36 expression was increased in obese subjects. Interestingly, miR-146a and miR-21 concentrations were negatively correlated to IL-6, TNF-α, and CD36 in obese participants.Conclusion: We demonstrate that the downregulation of miR-146a and miR-21 was associated with upregulation of inflammatory state and increased CD36 expression in obese participants.

journal_name

Arch Physiol Biochem

authors

Benbaibeche H,Hichami A,Oudjit B,Haffaf EM,Kacimi G,Koceïr EA,Khan NA

doi

10.1080/13813455.2020.1775655

subject

Has Abstract

pub_date

2020-06-13 00:00:00

pages

1-6

eissn

1381-3455

issn

1744-4160

pub_type

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