Downregulation of serum miR-106b: a potential biomarker for Alzheimer disease.

Abstract:

:Analysis of miRNAs has a strong potential for the identification of novel prognostic or predictive biomarkers in the serum of AD patients. In this study, we investigated the serum levels of miR-106b as a diagnostic biomarker for AD and evaluate its predictive value for therapeutic response to the drug rivastigmine. Patients were divided into either responding (n = 33) or non-responding (n = 23) groups according to rivastigmine treatment and to Mini-Mental State Exam score. The serum concentrations of miR-106b were measured with real-time PCR. Here, we found that miR-106b was significantly down-regulated in the serum samples of AD patients compared with those of controls (p < .001). ROC results showed a specificity of 62% and a sensitivity of 94%. The serum values of miR-106b tended to be positively associated with the therapeutic response but were not significant (p = .15). Taken together, detection of serum miR-106b might be a promising serum biomarker for early diagnosis of AD.

journal_name

Arch Physiol Biochem

authors

Madadi S,Saidijam M,Yavari B,Soleimani M

doi

10.1080/13813455.2020.1734842

subject

Has Abstract

pub_date

2020-03-06 00:00:00

pages

1-5

eissn

1381-3455

issn

1744-4160

pub_type

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