Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity.

abstract：:Pancreatic beta-cell mass expands through beta-cell proliferation and neogenesis while it decreases mainly via apoptosis. The loss of balance between beta-cell death and regeneration leads to a reduction of beta-cell functional mass, thus contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). The pathoge...

journal_title：Archives of physiology and biochemistry

authors： Tortosa F,Dotta F

更新日期：2013-10-01 00:00:00

abstract：:Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (...

journal_title：Archives of physiology and biochemistry

authors： Bassey IE,Ikpi DE,Isong IKP,Akpan UO,Onyeukwu CC,Nwankwo NP,Udofia IG

更新日期：2020-01-25 00:00:00

abstract：OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, ...

journal_title：Archives of physiology and biochemistry

authors： A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi S

更新日期：2021-01-20 00:00:00

abstract：:Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers.Materials and method...

journal_title：Archives of physiology and biochemistry

authors： Ebrahim HA,Alzamil NM,Al-Ani B,Haidara MA,Kamar SS,Dawood AF

更新日期：2020-06-04 00:00:00

abstract：INTRODUCTION:Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE:To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in wo...

journal_title：Archives of physiology and biochemistry

authors： Koleva DI,Orbetzova MM,Nikolova JG,Tyutyundzhiev SB

更新日期：2016-10-01 00:00:00

abstract：:Context: The anti-diabetic medicine metformin has been reported as an anti-ageing drug candidate as it mimics the benefits of caloric restriction and reduces ageing-related oxidative stress in various experimental organisms. Objective: We investigated the possible anti-oxidative role of metformin against rotenone-indu...

journal_title：Archives of physiology and biochemistry

authors： Tripathi SS,Singh AK,Akhtar F,Chaudhary A,Rizvi SI

更新日期：2019-06-01 00:00:00

abstract：:This study investigates the effects of the islet hormones insulin (Ins), glucagon (Glu), and somatostatin (Som) with nerve stimulation (EFS) acetylcholine (ACh) and cholecytokinin-octapeptide (CCK-8) on amylase secretion and intracellular free calcium concentration [Ca(2+)](i) in the pancreas of age-matched control an...

journal_title：Archives of physiology and biochemistry

authors： Singh J,Yago MD,Adeghate E

更新日期：2001-07-01 00:00:00

abstract：:This research was designed to detect the function of low-density lipoprotein receptor (LDLR)-related protein 8 (LRP8) in breast cancer (BC). Our results revealed that LRP8 was highly expressed in BC tissues and cell lines compared with human normal breast tissues. The poor prognosis of patients with BC was associated ...

journal_title：Archives of physiology and biochemistry

authors： Li L,Qu WH,Ma HP,Wang LL,Zhang YB,Ma Y

更新日期：2020-01-29 00:00:00

abstract：:The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Usi...

journal_title：Archives of physiology and biochemistry

authors： Horvath G,Wanner A

更新日期：2003-10-01 00:00:00

abstract：:An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

journal_title：Archives of physiology and biochemistry

authors： Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

更新日期：2000-07-01 00:00:00

abstract：:We reasoned that micro-dissection of tumour cells for protein expression studies should be omitted since tumour-stroma interactions are an important part of the biology of solid tumours. To study such interactions in head and neck squamous cell carcinoma (HNSCC) development, we generated reference protein spectra for ...

journal_title：Archives of physiology and biochemistry

authors： Roesch-Ely M,Schnölzer M,Nees M,Plinkert PK,Bosch FX

更新日期：2010-10-01 00:00:00

abstract：:Analysis of miRNAs has a strong potential for the identification of novel prognostic or predictive biomarkers in the serum of AD patients. In this study, we investigated the serum levels of miR-106b as a diagnostic biomarker for AD and evaluate its predictive value for therapeutic response to the drug rivastigmine. Pa...

journal_title：Archives of physiology and biochemistry

authors： Madadi S,Saidijam M,Yavari B,Soleimani M

更新日期：2020-03-06 00:00:00

abstract：CONTEXT:Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE:This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS:Th...

journal_title：Archives of physiology and biochemistry

authors： Bouzenna H,Hfaiedh N,Bouaziz M,Giroux-Metges MA,Elfeki A,Talarmin H

更新日期：2017-12-01 00:00:00

abstract：:Diabetes represents an important public health problem. Recently, new molecular targets have been identified and exploited to treat this disease. Due to its pivotal role in glucose homeostasis, glucokinase (GCK) is a promising target for the development of novel antidiabetic drugs; however, pharmacological agents that...

journal_title：Archives of physiology and biochemistry

authors： Guzmán TJ,Gurrola-Díaz CM

更新日期：2019-06-18 00:00:00

abstract：:Curcumin (diferuloylmethane) is an orange-yellow component of turmeric (Curcuma longa), a spice often found in curry powder. In recent years, considerable interest has been focused on curcumin due to its use to treat a wide variety of disorders without any side effects. It is one of the major curcuminoids of turmeric,...

journal_title：Archives of physiology and biochemistry

authors： Pari L,Tewas D,Eckel J

更新日期：2008-04-01 00:00:00

abstract：:Aim: This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods: Male infertility was induced in rat by intrape...

journal_title：Archives of physiology and biochemistry

authors： Ghareeb DA,Abd-Elgwad A,El-Guindy N,Yacout G,Zaatout HH

更新日期：2019-07-31 00:00:00

abstract：:This study investigated the effect of eight weeks of aerobic training (AT) combined with silymarin (S)consumption on glycemic indices and liver enzymes in men with type 2 diabetes (T2D). In this clinical trial, 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) C + placebo(C) (2) AT + p...

journal_title：Archives of physiology and biochemistry

authors： Ghalandari K,Shabani M,Khajehlandi A,Mohammadi A

更新日期：2020-08-04 00:00:00

abstract：:The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a pathologically low level upon intracerebral injection adjacent to the MCA. This reduction manifests itself as an ischemic infarct, that is fully de...

journal_title：Archives of physiology and biochemistry

authors： Moyanova S,Kortenska L,Kirov R,Iliev I

更新日期：1998-12-01 00:00:00

abstract：:Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS in...

journal_title：Archives of physiology and biochemistry

authors： Luo X,Yang X,Yang Y,Li H,Cui H,Cao X

更新日期：2020-07-01 00:00:00

abstract：:This study was carried out to determine a possible relationship between hepatic acetyl-coenzyme A carboxylase EC 6.4.1.2 (ACC) activity in dam and fetus at 15-day and 19-day of gestation and the glucose tolerance in pregnant rats fed on the sucrose diet compared with the rats feed on the dextrin diet. Sucrose feeding ...

journal_title：Archives of physiology and biochemistry

authors： Oliveros L,Callegari E,Giménez MS

更新日期：1997-12-01 00:00:00

abstract：:This study was to investigate whether epidermal growth factor (EGF) may induce any long-term effect on pancreatic exocrine function in vivo as well to evaluate the chronic effects of EGF on pancreatic growth in rats. Rats were treated with EGF (10 micrograms/kg) for 5 or 7 days. EGF infused intravenously (2 micrograms...

journal_title：Archives of physiology and biochemistry

authors： Lajas AI,Pozo MJ,Salido GM,Singh J,Pariente JA

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND AIM:Tobago and Trinidad are two Caribbean islands with distinct genetic background and lifestyles; while Tobago is serene and a tourist centre, Trinidad is characterized by a hustling and bustling lifestyle. The study was aimed at determining and comparing the prevalence of the metabolic syndrome (MetS) ...

journal_title：Archives of physiology and biochemistry

authors： Ezenwaka CE,Nwagbara E,Seales D,Okali F,Hussaini S,Raja B,Wheeler V,Sell H,Avci H,Eckel J

更新日期：2007-10-01 00:00:00

abstract：:Adipose tissue is a critical regulator of energy balance and substrate metabolism, and synthesizes several different substances with endocrine or paracrine functions, which regulate the overall energetic homeostasis. An excessive amount of adipose tissue has been associated with the development of type 2 diabetes, pre...

journal_title：Archives of physiology and biochemistry

authors： Laviola L,Perrini S,Cignarelli A,Giorgino F

更新日期：2006-04-01 00:00:00

abstract：:It is known that channel catfish erythrocytes can take up glycine by several distinct transport systems. Further, glycine is an inhibitory neurotransmitter in mammalian brain and spinal cord. Consequently, the uptake of [(3)H]glycine by catfish brain was investigated and found to be a saturable process, dependent on t...

journal_title：Archives of physiology and biochemistry

authors： Wolf TR,Lance RA,Hart ER,Tunnicliff G

更新日期：1999-04-01 00:00:00

abstract：:A-4166, a phenylalanine derivative, is a hypoglycemic agent, which has been shown to improve blood glucose levels mainly due to the rapid and short term stimulation of insulin release. Nevertheless, a possible extrapancreatic action of A-4166 has not yet been investigated. Therefore, insulin action (euglycemic hyperin...

journal_title：Archives of physiology and biochemistry

authors： Klimes I,Mitková A,Gasperíková D,Ukropec J,Líska B,Bohov P,Stanek J,Seböková E

更新日期：1998-10-01 00:00:00

abstract：:A novel molecular mechanism for the regulation of lipid metabolism by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes was recently elucidated. It encompasses the translocation of the glycosylphosphatidylinositol-anchored (GPI-) and (c)AMP degrading enzymes Gce1 and CD73 from det...

journal_title：Archives of physiology and biochemistry

authors： Müller G,Schulz A,Dearey EA,Wetekam EM,Wied S,Frick W

更新日期：2010-07-01 00:00:00

abstract：:The actions of the insulin-like growth factor (IGF)-system are controlled by six IGF-binding proteins (IGFBPs). The IGFBPs are thought to affect local effects of IGF-I and IGF-II due to higher affinity if compared to IGF-I receptors and due to cell-type specific IGFBP expression patterns. It was found in IGFBP knockou...

journal_title：Archives of physiology and biochemistry

authors： Hoeflich A,Götz W,Lichanska AM,Bielohuby M,Tönshoff B,Kiepe D

更新日期：2007-06-01 00:00:00

abstract：:Background: We aim to identify and analyze the expression of dyregulated RNAs in colorectal cancer (CRC). Methods: We selected a panel of RNAs specific to CRC composed of Nucleosome Assembly Protein 1 Like 2 (NAP1L2) mRNA, LNCRNA SNHG14 small nucleolar RNA host gene 14 (LNCRNA SNHG14) and homo sapiens microRNA-3940-5p...

journal_title：Archives of physiology and biochemistry

authors： Matboli M,Shafei AE,Ali MA,El-Din Ahmed TS,Naser M,Abdel-Rahman T,Anber N,Ali M

更新日期：2019-08-09 00:00:00

abstract：:Changes in body fluid distribution are known to influence neuroendocrine function. The aim of the present study was to test the hypothesis that changes in plasma volume affect the counterregulatory neuroendocrine response to hypoglycemia. The tests were performed in 12 subjects in two situations: 'head-up' (+60 degree...

journal_title：Archives of physiology and biochemistry

authors： Radikova Z,Penesova A,Jezova D,Kvetnansky R,Vigas M,Macho L,Koska J

更新日期：2003-10-01 00:00:00

abstract：:Introduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a signif...

journal_title：Archives of physiology and biochemistry

authors： Acar A,Akkoc H,Erdinc M

更新日期：2019-06-07 00:00:00