Abstract:
:It is known that channel catfish erythrocytes can take up glycine by several distinct transport systems. Further, glycine is an inhibitory neurotransmitter in mammalian brain and spinal cord. Consequently, the uptake of [(3)H]glycine by catfish brain was investigated and found to be a saturable process, dependent on the presence of Na(++) and Cl(--) and sensitive to temperature. A kinetic analysis of transport was performed at 22C. This showed that a high-affinity system existed which exhibited a K(m) of 5.1 (+/- 2. 1) microM. Several structural analogues of glycine were capable of inhibiting uptake in a competitive manner. The most effective inhibitor was sarcosine (IC(50) 5 36 microM). Uptake was also able to be inhibited by harmaline, a drug known to interfere with Na(+)-dependent transport processes. It is concluded that glycine transport by channel catfish brain has much in common with transport by mammalian nervous tissue which is carried out by the membrane carriers GLYT1 and GLYT2. On the other hand, synaptosomal transport differs somewhat from glycine transport by channel catfish erythrocytes.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Wolf TR,Lance RA,Hart ER,Tunnicliff Gdoi
10.1076/apab.107.2.84.4349subject
Has Abstractpub_date
1999-04-01 00:00:00pages
84-90issue
2eissn
1381-3455issn
1744-4160journal_volume
107pub_type
杂志文章abstract::This study investigated the effects of garlic on anxiety- and depression-related behaviors and brain oxidative markers in streptozotocin (STZ)-induced diabetes in rats. Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8/group): control, diabetic + saline, diabetic + garlic, diabetic...
journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
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