Abstract:
:Hepatotoxicity, induced by aluminium chloride (AlCl3), has been well studied but there are no reports about liver metallothionein (MT) genes induction. Therefore, it is of interest to establish the mechanism involving the relation between MT gene expression levels and the oxidative stress status in hepatic cells of aluminium-treated rats. Aluminium (Al) was administered to rats in their drinking water at a dose of 50 mg/kg body weight for three weeks. AlCl3 provoked hepatotoxicity objectified by an increase in malondialdehyde (MDA), hydrogen peroxide (H2O2), advanced oxidation protein products (AOPP), protein carbonyls (PCO) and a decrease in reduced glutathione (GSH), non-protein thiols (NPSH) and vitamin C. CAT and Glutathione peroxidase (GPx) activities were decreased while Mn-SOD gene expression, total Metallothionein content and MT I and MT II genes induction were increased. There are changes in plasma of some trace elements, albumin levels, transaminases, LDH and ALP activities. All these changes were supported by histopathological observations.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Ghorbel I,Chaabane M,Elwej A,Boudawara O,Abdelhedi S,Jamoussi K,Boudawara T,Zeghal Ndoi
10.1080/13813455.2016.1187176subject
Has Abstractpub_date
2016-10-01 00:00:00pages
214-222issue
4eissn
1381-3455issn
1744-4160journal_volume
122pub_type
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
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journal_title:Archives of physiology and biochemistry
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pub_type: 杂志文章,评审
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更新日期:1998-02-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
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