Body position and the neuroendocrine response to insulin-induced hypoglycemia in healthy subjects.

Abstract:

:Changes in body fluid distribution are known to influence neuroendocrine function. The aim of the present study was to test the hypothesis that changes in plasma volume affect the counterregulatory neuroendocrine response to hypoglycemia. The tests were performed in 12 subjects in two situations: 'head-up' (+60 degrees head-up tilt standing for 30 min and hypoglycemia in sitting position afterwards) and 'leg-up' (leg-up position for 30 min and hypoglycemia in leg-up position afterwards) in a random order. Insulin-induced hypoglycemia was adjusted to 2.7 mmol/l for 15 min by glucose infusion. Plasma volume was greater by 2.2% (p < 0.001) in leg-up and lower by 9.6% (p < 0.001) in head-up position compared to the basal value in sitting position. Head-up position was associated with increases in ACTH, aldosterone, norepinephrine levels and plasma renin activity (p < 0.01). Leg-up position resulted in decreases in plasma growth hormone and epinephrine concentrations (p < 0.05). Except epinephrine, the neuroendocrine response to hypoglycemia, if any, was mild. Hypoglycemia failed to activate ACTH release after head-up position. Body fluid redistribution did not modify hormonal changes during insulin hypoglycemia. In conclusion, we suggest that body position and accompanying plasma volume changes do not appear to affect neuroendocrine and counterregulatory responses to moderate, short duration hypoglycemia in healthy subjects.

journal_name

Arch Physiol Biochem

authors

Radikova Z,Penesova A,Jezova D,Kvetnansky R,Vigas M,Macho L,Koska J

doi

10.3109/13813450312331337658

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

399-405

issue

4

eissn

1381-3455

issn

1744-4160

pii

LD0WKVXHT1CNELPE

journal_volume

111

pub_type

杂志文章
  • Mammalian gonadotropin-releasing hormone (GnRH) receptor subtypes.

    abstract::Mammalian gonadotropin-releasing hormone (GnRH I) is a hypothalamic decapeptide that governs gonadotropin secretion through interaction with its seven transmembrane (7TM), G protein-coupled receptor (GPCR) expressed by anterior pituitary cells. A second decapeptide, GnRH II, originally discovered in the chicken hypoth...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.110.1.129.900

    authors: Neill JD

    更新日期:2002-04-01 00:00:00

  • Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women.

    abstract::The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1171365

    authors: Çelik F,Belviranli M,Okudan N

    更新日期:2016-10-01 00:00:00

  • The interrelationship between inflammatory cytokines and skeletal muscle decay from the viewpoint of circadian rhythms.

    abstract::Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS in...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1782435

    authors: Luo X,Yang X,Yang Y,Li H,Cui H,Cao X

    更新日期:2020-07-01 00:00:00

  • Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods.

    abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.104.6.752.12911

    authors: Hess GP

    更新日期:1996-10-01 00:00:00

  • Nandrolone modulates the non-opioid and opioid analgesia and tolerance/dependence: role of sexual dimorphism.

    abstract::The aim of this investigation was to study the effect of the doping steroid nandrolone on metamizol and morphine-induced analgesia and tolerance/dependence in rats. Nandrolone per se did not change the basal nociceptive thresholds in both sexes. It diminished the analgesic effect of metamizol in females, revealed by t...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331342283

    authors: Philipova T,Ivanova T,Pavlova E,Kasakov L,Vlaskovska M

    更新日期:2003-12-01 00:00:00

  • Physiological role of adiponectin in different tissues: a review.

    abstract::Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. This role is...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813455.2018.1493606

    authors: Esmaili S,Hemmati M,Karamian M

    更新日期:2020-02-01 00:00:00

  • Downregulation of serum miR-106b: a potential biomarker for Alzheimer disease.

    abstract::Analysis of miRNAs has a strong potential for the identification of novel prognostic or predictive biomarkers in the serum of AD patients. In this study, we investigated the serum levels of miR-106b as a diagnostic biomarker for AD and evaluate its predictive value for therapeutic response to the drug rivastigmine. Pa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1734842

    authors: Madadi S,Saidijam M,Yavari B,Soleimani M

    更新日期:2020-03-06 00:00:00

  • Sputum adenosine deaminase and alkaline phosphatase activity in pulmonary tuberculosis.

    abstract:OBJECTIVE:The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis. METHODS:This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum. RESULTS:The...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.645545

    authors: Jadhav AA,Jain A

    更新日期:2012-02-01 00:00:00

  • LncRNA RPSAP52 regulates miR-423-5p/GSTM1 axis to suppress hypoxia-induced renal proximal tubular epithelial cell apoptosis.

    abstract::This study aimed to investigate the roles of RPSAP52 in renal failure. Our results showed that RPSAP52 was upregulated in plasma of renal failure patients in comparison to healthy controls. Dual luciferase reporter assay showed that RPSAP52 could interact with miR-423-5p, while overexpression of RPSAP52 and miR-423-5p...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1750657

    authors: Chen J,Zheng Y,Li L

    更新日期:2020-04-17 00:00:00

  • Biomechanical events in the time to exhaustion at maximum aerobic speed.

    abstract::Recent studies reported good intra-individual reproducibility, but great inter-individual variation in a sample of elite athletes, in time to exhaustion (tlim) at the maximal aerobic speed (MAS: the lowest speed that elicits VO2max in an incremental treadmill test). The purpose of the present study was, on the one han...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.6.583.3272

    authors: Gazeau F,Koralsztein JP,Billat V

    更新日期:1997-10-01 00:00:00

  • Biliary secretion in suckling goats: the effect of maternal milk and of a lamb milk replacer.

    abstract::A total of 45 preruminant goats were fed either goat milk or a milk substitute. The postnatal development of bile secretion and biliary lipids composition of suckling goats and the influence upon these parameters of maternal milk substitution were studied during the first month of life. Samples of hepatic and gallblad...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.104.2.239.12876

    authors: Rueda A,Valverde A,Fernandez JA,Martinez-Victoria E,Naranjo JA,Mañas M

    更新日期:1996-01-01 00:00:00

  • Role of some circulating MiRNAs on breast cancer diagnosis.

    abstract::Aberrant expression of miRNAs has a link with tumorgenesis and their deregulation is reported in biological fluids of cancer patients. Authors aimed to investigate the diagnostic role of miRNA-17-5p, miR-155 and miRNA-222 in serum samples from breast cancer patients (n = 80), benign breast patients (n = 40) and health...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1482355

    authors: Swellam M,Zahran RFK,Abo El-Sadat Taha H,El-Khazragy N,Abdel-Malak C

    更新日期:2019-12-01 00:00:00

  • Adipokines enhance oleic acid-induced proliferation of vascular smooth muscle cells by inducing CD36 expression.

    abstract::Adipose tissue is not only releasing lipids but also various adipokines that are both dysregulated in the obese state and may contribute to obesity-associated vascular dysfunction and cardiovascular risk. We have previously shown that the combination of adipocyte-conditioned medium (CM) and oleic acid (OA) increases p...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2015.1045520

    authors: Schlich R,Lamers D,Eckel J,Sell H

    更新日期:2015-01-01 00:00:00

  • Demographic and lifestyle factors that affect HbA1c awareness amongst type II diabetic patients in Trinidad.

    abstract:OBJECTIVES:To determine the awareness of HbA1c values and correlate this with educational levels, dietary intake and physical activity in type II diabetic population of Trinidad. METHODS:Total of 222 type II diabetic subjects were assessed via questionnaire evaluating their demographics, type and duration of diabetes,...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,多中心研究

    doi:10.1080/13813455.2017.1412466

    authors: Nayak BS,Khan K,Kidney C,Knowles V,Koo A,Lakhan A,Lalla D,Lalloo C,Lallo SA,Singh S

    更新日期:2018-12-01 00:00:00

  • Ghrelin prevents cardiac cell apoptosis during cardiac remodelling post experimentally induced myocardial infarction in rats via activation of Raf-MEK1/2-ERK1/2 signalling.

    abstract:CONTEXT:Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear. OBJECTIVE:To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway. MATERIALS AND METHODS:Rats were divided into control, sham, sham + ghreli...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1437751

    authors: Eid RA,Alkhateeb MA,Al-Shraim M,Eleawa SM,Shatoor AS,El-Kott AF,Zaki MSA,Shatoor KA,Bin-Jaliah I,Al-Hashem FH

    更新日期:2019-05-01 00:00:00

  • The role of vasopressin V1A and oxytocin OTR receptors in protective effects of arginine vasopressin against H2O2-induced oxidative stress in H9C2 cells.

    abstract::Background: Oxidative stress, has been shown to play an important role in the pathophysiology of cardiac remodelling and heart failure. The aim of study is effect of arginine vasopressin (AVP) on apoptosis of cardiomyocyte via its receptors.Materials and methods: The cell viability effect of AVP in H9C2 cardiomyocytes...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1729816

    authors: Ghorbanzadeh V,Jafarpour A,Pirnia A,Pajouhi N,Khaksarian M,Veiskarami S,Nazari A

    更新日期:2020-03-06 00:00:00

  • Effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters and serum oxidative stress markers in fructose-induced diabetic Wistar rats.

    abstract::Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1716017

    authors: Bassey IE,Ikpi DE,Isong IKP,Akpan UO,Onyeukwu CC,Nwankwo NP,Udofia IG

    更新日期:2020-01-25 00:00:00

  • Synthetic phosphoinositolglycans regulate lipid metabolism between rat adipocytes via release of GPI-protein-harbouring adiposomes.

    abstract::A novel molecular mechanism for the regulation of lipid metabolism by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes was recently elucidated. It encompasses the translocation of the glycosylphosphatidylinositol-anchored (GPI-) and (c)AMP degrading enzymes Gce1 and CD73 from det...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.485205

    authors: Müller G,Schulz A,Dearey EA,Wetekam EM,Wied S,Frick W

    更新日期:2010-07-01 00:00:00

  • New insights into the in vitro, in situ and in vivo antihyperglycemic mechanisms of gallic acid and p-coumaric acid.

    abstract::Objective: To explore the probable in vitro, in situ and in vivo mechanisms of gallic acid (GA) and p-coumaric acid (PCA) as anti-hyperglycemic agents.Animals and methods: Male albino rats were allocated into four groups, group1 was used as normal control. Group 2 was established as a diabetic control and group3 and 4...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1762659

    authors: Abdel-Moneim A,Abd El-Twab SM,Yousef AI,Ashour MB,Reheim ESA,Hamed MAA

    更新日期:2020-05-13 00:00:00

  • Each of the four intracellular cysteines of CD36 is essential for insulin- or AMP-activated protein kinase-induced CD36 translocation.

    abstract::Stimulation of cellular fatty acid uptake by induction of insulin signalling or AMP-kinase (AMPK) activation is due to translocation of the fatty acid-transporter CD36 from intracellular stores to the plasma membrane (PM). For investigating the role of the four Cys-residues within CD36's cytoplasmic tails in CD36 tran...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2013.876049

    authors: van Oort MM,Drost R,Janβen L,Van Doorn JM,Kerver J,Van der Horst DJ,Luiken JJ,Rodenburg KC

    更新日期:2014-02-01 00:00:00

  • Effect of aerobic training with silymarin consumption on glycemic indices and liver enzymes in men with type 2 diabetes.

    abstract::This study investigated the effect of eight weeks of aerobic training (AT) combined with silymarin (S)consumption on glycemic indices and liver enzymes in men with type 2 diabetes (T2D). In this clinical trial, 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) C + placebo(C) (2) AT + p...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1797104

    authors: Ghalandari K,Shabani M,Khajehlandi A,Mohammadi A

    更新日期:2020-08-04 00:00:00

  • Mechanoreceptors in the glabrous skin of the human hand.

    abstract::Since the first systematic analysis concerning the functional properties of mechanoreceptors in the glabrous skin of the human hand was made in 1970, the amount of available data has grown tremendously. Whereas the first research in the seventies was aimed at achieving a standard functional description of the mechanor...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/13813455199908107041qft338

    authors: Pasterkamp E

    更新日期:1999-10-01 00:00:00

  • Evaluation of indoleamine 2,3-dioxygenase expression and kynurenine pathway metabolites levels in serum samples of diabetic retinopathy patients.

    abstract:CONTEXT:Diabetic retinopathy (DR) is the leading cause of acquired blindness. The involvement of indoleamine 2, 3-dioxygenase (IDO) and kynurenines, the products of tryptophan degradation in various pathological conditions was well documented. OBJECTIVE:The aim of the present study was to determine the expression of I...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.623705

    authors: Munipally PK,Agraharm SG,Valavala VK,Gundae S,Turlapati NR

    更新日期:2011-12-01 00:00:00

  • Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity.

    abstract::Context: The anti-diabetic medicine metformin has been reported as an anti-ageing drug candidate as it mimics the benefits of caloric restriction and reduces ageing-related oxidative stress in various experimental organisms. Objective: We investigated the possible anti-oxidative role of metformin against rotenone-indu...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1620288

    authors: Tripathi SS,Singh AK,Akhtar F,Chaudhary A,Rizvi SI

    更新日期:2019-06-01 00:00:00

  • Mass spectrometry-based proteomics and its potential use in haematological research.

    abstract::In the last decade proteomics has made great progress reaching throughput and comprehensiveness comparable to genomics technologies. Mass spectrometry plays a key role in proteomics and has become an indispensable method for molecular and cellular biology because many cellular changes in response to internal or extern...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.3109/13813450903428086

    authors: Fröbel J,Lehr S,Haas R,Czibere A

    更新日期:2009-12-01 00:00:00

  • Effects of insulin-like growth factor binding proteins in bone -- a matter of cell and site.

    abstract::The actions of the insulin-like growth factor (IGF)-system are controlled by six IGF-binding proteins (IGFBPs). The IGFBPs are thought to affect local effects of IGF-I and IGF-II due to higher affinity if compared to IGF-I receptors and due to cell-type specific IGFBP expression patterns. It was found in IGFBP knockou...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450701531193

    authors: Hoeflich A,Götz W,Lichanska AM,Bielohuby M,Tönshoff B,Kiepe D

    更新日期:2007-06-01 00:00:00

  • Long non-coding RNA MEG3 and its genetic variant rs941576 are associated with rheumatoid arthritis pathogenesis in Egyptian patients.

    abstract::Background: Rheumatoid arthritis (RA) is a joint destructive disorder. This study aimed to assess lncRNA MEG3 expression and its variant rs941576 in Egyptian patients with RA.Subjects and methods: 100 RA patients and 100 healthy individuals were enrolled in the study. Quantitative PCR was used for expression analysis ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1784951

    authors: Wahba AS,Ibrahim ME,Mesbah NM,Saleh SM,Abo-Elmatty DM,Mehanna ET

    更新日期:2020-07-01 00:00:00

  • Insulin signalling in human adipose tissue.

    abstract::Adipose tissue is a critical regulator of energy balance and substrate metabolism, and synthesizes several different substances with endocrine or paracrine functions, which regulate the overall energetic homeostasis. An excessive amount of adipose tissue has been associated with the development of type 2 diabetes, pre...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450600736174

    authors: Laviola L,Perrini S,Cignarelli A,Giorgino F

    更新日期:2006-04-01 00:00:00

  • Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents.

    abstract::Glycogen synthesis increases after muscle contraction and during insulin stimulation, and insulin-stimulated glycogen synthesis is enhanced after contraction. We hypothesized that the initial glycogen content influences the magnitude of additive effect of contraction on insulin-stimulated glycogen synthesis. Contracti...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.494670

    authors: Lai YC,Stuenaes JT,Kuo CH,Jensen J

    更新日期:2010-07-01 00:00:00

  • Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway.

    abstract:OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1874017

    authors: A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi S

    更新日期:2021-01-20 00:00:00