Abstract:
:Stimulation of cellular fatty acid uptake by induction of insulin signalling or AMP-kinase (AMPK) activation is due to translocation of the fatty acid-transporter CD36 from intracellular stores to the plasma membrane (PM). For investigating the role of the four Cys-residues within CD36's cytoplasmic tails in CD36 translocation, we constructed CHO-cells expressing CD36 mutants in which all four, two, or one of the intracellular Cys were replaced by Ser. Intracellular and PM localization of all mutants was similar to wild-type CD36 (CD36wt). Hence, the four Cys do not regulate sub-cellular CD36 localization. However, in contrast to CD36wt, insulin or AMPK activation failed to induce translocation of any of the mutants, indicating that all four intracellular Cys residues are essential for CD36 translocation. The mechanism of defective translocation of mutant CD36 is unknown, but appears not due to loss of S-palmitoylation of the cytoplasmic tails or to aberrant oligomerization of the mutants.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
van Oort MM,Drost R,Janβen L,Van Doorn JM,Kerver J,Van der Horst DJ,Luiken JJ,Rodenburg KCdoi
10.3109/13813455.2013.876049subject
Has Abstractpub_date
2014-02-01 00:00:00pages
40-9issue
1eissn
1381-3455issn
1744-4160journal_volume
120pub_type
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