Urinary sulphated glycosaminoglycans excretion in obese patients with type 2 diabetes mellitus treated with metformin.

Abstract:

:Objective: The pattern of urinary excretion of total sulphated glycosaminoglycans (GAGs) and their particular types: chondroitin sulphate/dermatan sulphate (CS/DS) and heparan sulphate (HS) was analysed in obese patients with type 2 diabetes mellitus (T2DM) treated with metformin in monotherapy for the period of six months.Methods: The urinary sulphated glycosaminoglycans were quantitated using standardised dye (1.9-dimethylmethylene blue)-binding method and normalised to creatinine level.Results: Urinary total GAGs, CS/DS and HS levels were significantly higher in untreated diabetic patients in comparison to healthy subjects. Moreover, it was observed that urinary total GAGs, CS/DS and HS levels in diabetic patients after six-month metformin therapy were significantly decreased versus pre-treatment situation.Conclusions: The obtained results suggest that the six-month treatment with metformin in obese patients with T2DM has a regulating influence on the systemic changes in proteoglycans/glycosaminoglycans, resulting in a decrease in the urinary excretion of total GAGs, CS/DS and HS.

journal_name

Arch Physiol Biochem

authors

Jura-Półtorak A,Olczyk P,Chałas-Lipka A,Komosińska-Vassev K,Kuźnik-Trocha K,Winsz-Szczotka K,Ivanova D,Kiselova-Kaneva Y,Krysik K,Telega A,Olczyk K

doi

10.1080/13813455.2019.1697889

subject

Has Abstract

pub_date

2019-12-09 00:00:00

pages

1-7

eissn

1381-3455

issn

1744-4160

pub_type

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