Interleukin-6 is a negative regulator of hepatic glucose production in the isolated rat liver.

Abstract:

:The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6) is known to be released during exercise and is thought that either IL-6 directly or via a "contraction factor" stimulates the release of stored glucose from the liver. Here we show that IL-6 does not directly increase hepatic glucose output (HGO). Moreover, IL-6 infused at the same time as glucagon caused a significant reduction in HGO. IL-6 infused with epinephrine caused no synergenic increase in HGO. To test if an unknown "contraction factor" was needed along with IL-6 to increase HGO, we used human fasted and exercised plasma perfused with or without IL-6 in our isolated liver system. We found that exercised plasma increased HGO, as expected, but when infused with IL-6, reductions in HGO were found. Our results provide evidence that IL-6 works as a negative regulator of HGO.

journal_name

Arch Physiol Biochem

authors

Dent JR,Chowdhury MK,Tchijov S,Dulson D,Smith G

doi

10.3109/13813455.2016.1146773

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

103-9

issue

2

eissn

1381-3455

issn

1744-4160

journal_volume

122

pub_type

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