Abstract:
:Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of advanced glycation end products (AGEs) exerting their adverse effects via receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n = 94) or DN (n = 171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P = 0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P < 0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P = 0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P > 0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Kanková K,Kalousová M,Hertlová M,Krusová D,Olsovský J,Zima Tdoi
10.1080/13813450802033818subject
Has Abstractpub_date
2008-04-01 00:00:00pages
111-9issue
2eissn
1381-3455issn
1744-4160journal_volume
114pub_type
杂志文章abstract:INTRODUCTION:Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE:To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in wo...
journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
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更新日期:2003-10-01 00:00:00
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更新日期:2012-02-01 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
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更新日期:1996-10-01 00:00:00
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journal_title:Archives of physiology and biochemistry
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/13813455199908107041qft338
更新日期:1999-10-01 00:00:00
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journal_title:Archives of physiology and biochemistry
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更新日期:2020-09-29 00:00:00
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journal_title:Archives of physiology and biochemistry
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更新日期:2014-02-01 00:00:00
abstract::Due to the importance of zinc as an antioxidant and its crucial role in insulin synthesis, its deficiency may affect adversely diabetic state. So, this study aimed to modulate these effects using Curcuma longa as natural antioxidant. Rats were divided into four groups: two groups fed a zinc sufficient diet one non-dia...
journal_title:Archives of physiology and biochemistry
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更新日期:2019-11-15 00:00:00
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journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
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更新日期:2013-10-01 00:00:00
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更新日期:2000-12-01 00:00:00
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更新日期:1998-07-01 00:00:00
abstract::We reasoned that micro-dissection of tumour cells for protein expression studies should be omitted since tumour-stroma interactions are an important part of the biology of solid tumours. To study such interactions in head and neck squamous cell carcinoma (HNSCC) development, we generated reference protein spectra for ...
journal_title:Archives of physiology and biochemistry
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更新日期:2010-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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更新日期:2006-10-01 00:00:00