Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene.

Abstract:

:Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of advanced glycation end products (AGEs) exerting their adverse effects via receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. We studied relationships between sRAGE, renal function and genetic variability in the AGER gene in diabetic subjects. Study comprised a total of 265 diabetics (type 1 or 2 or LADA) with normoalbuminuria (n = 94) or DN (n = 171). sRAGE (assessed by ELISA) was significantly higher in DN than normoalbuminuria subjects (P = 0.007) and positively correlated with age, S-urea, S-creatinine and albuminuria and AGEs (determined spectrofluorimetrically), negatively with GFR (all P < 0.05); however, multivariate regression revealed that GFR was the only independent variable associated with sRAGE (P = 0.047). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2) (P > 0.05). In conclusion, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs.

journal_name

Arch Physiol Biochem

authors

Kanková K,Kalousová M,Hertlová M,Krusová D,Olsovský J,Zima T

doi

10.1080/13813450802033818

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

111-9

issue

2

eissn

1381-3455

issn

1744-4160

journal_volume

114

pub_type

杂志文章
  • Adipokines and soluble cell adhesion molecules in insulin resistant and non-insulin resistant women with polycystic ovary syndrome.

    abstract:INTRODUCTION:Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE:To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in wo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2016.1190760

    authors: Koleva DI,Orbetzova MM,Nikolova JG,Tyutyundzhiev SB

    更新日期:2016-10-01 00:00:00

  • Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals.

    abstract::Aim: This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods: Male infertility was induced in rat by intrape...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1645698

    authors: Ghareeb DA,Abd-Elgwad A,El-Guindy N,Yacout G,Zaatout HH

    更新日期:2019-07-31 00:00:00

  • CPSF1 mediates retinal vascular dysfunction in diabetes mellitus via the MAPK/ERK pathway.

    abstract::This study investigated the expression and underlying molecular mechanism of CPSF1 in diabetic retinopathy. Streptozotocin (STZ)-induced Sprague-Dawley (SD) rats were employed as a diabetic model, and high-glucose (HG)-induced human retinal vascular endothelial cells (HRVECs)were used as an in vitro experimental model...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1722704

    authors: Zhang J,Zhang X,Zou Y,Han F

    更新日期:2020-02-12 00:00:00

  • [Analysis of iodine compounds in young rat skin in the period of suckling and in the adult. Effect of perchlorate].

    abstract::In the suckling and adult rats equilibrated or no by 125I, cutaneous iodine analysed by dialysis and chromatography techniques (Dowex and Sephadex) was the purpose of this study. Dialysis studies had shown that most of steady or labelled skin iodine had an iodide form (90 to 95% of the total iodine). There were at lea...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813459509047146

    authors: Zeghal N,Redjem M,Gondran F,Vigouroux E

    更新日期:1995-08-01 00:00:00

  • Quantitative electroencephalographic changes due to middle cerebral artery occlusion by endothelin 1 in conscious rats.

    abstract::The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a pathologically low level upon intracerebral injection adjacent to the MCA. This reduction manifests itself as an ischemic infarct, that is fully de...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.106.5.384.4362

    authors: Moyanova S,Kortenska L,Kirov R,Iliev I

    更新日期:1998-12-01 00:00:00

  • Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women.

    abstract::The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1171365

    authors: Çelik F,Belviranli M,Okudan N

    更新日期:2016-10-01 00:00:00

  • Evaluating the effects of Juglans regia L. extract on hyperglycaemia and insulin sensitivity in experimental type 2 diabetes in rat.

    abstract::Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1668018

    authors: Atila Uslu G,Uslu H

    更新日期:2019-09-23 00:00:00

  • Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H2O2-induced oxidative stress.

    abstract::Context: Recent surveys have shown an association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and oxidative stress.Objective: In this investigation, the effect of evolocumab an anti-PCSK9 antibody was assessed against oxidative damage caused by hydrogen peroxide (H2O2) in human umbilical vein endothe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1788605

    authors: Safaeian L,Mirian M,Bahrizadeh S

    更新日期:2020-07-03 00:00:00

  • Enhanced luminescence study of liver homogenate response to oxidative stress.

    abstract::An enhanced luminescence technique was used to monitor the response of liver homogenates stressed with sodium perborate. Rat liver homogenates were subjected to oxidative stress with sodium perborate, and the light signals, generated by a suitable system, containing luminol and compounds producing enhancement of light...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813459508996132

    authors: Di Meo S,Venditti P,Piro MC,De Leo T

    更新日期:1995-05-01 00:00:00

  • Synthetic phosphoinositolglycans regulate lipid metabolism between rat adipocytes via release of GPI-protein-harbouring adiposomes.

    abstract::A novel molecular mechanism for the regulation of lipid metabolism by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes was recently elucidated. It encompasses the translocation of the glycosylphosphatidylinositol-anchored (GPI-) and (c)AMP degrading enzymes Gce1 and CD73 from det...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.485205

    authors: Müller G,Schulz A,Dearey EA,Wetekam EM,Wied S,Frick W

    更新日期:2010-07-01 00:00:00

  • Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine.

    abstract::Dopamine (DA) is thought to modulate the transduction of the hypoxic stimulus by the glomus cell in the carotid body (CB). The hypothesis tested here is that presynaptic DA D2 receptors (D2's) located on the type 1 cell function as autoreceptors to control DA release and/or synthesis. The aim of the study was to compa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.1.3.13145

    authors: Basson H,Bairam A,Cottet-Emard JM,Pequignot JM,Marchal F

    更新日期:1997-02-01 00:00:00

  • Use of a simple fractionation method to evaluate binding, internalization and intracellular distribution of oligonucleotides in vascular smooth muscle cells.

    abstract::Antisense oligonucleotides (ODN) are potent molecules that could be used to inhibit the synthesis of a protein specifically if delivered to the appropriate compartments (cytoplasm and nucleus) of the cell under study. We present here a simple method providing access to the fractions of internalized ODN available in th...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.111.3.265.23465

    authors: Eboue D,Auger R,Angiari C,Le Doan T,Tenu JP

    更新日期:2003-07-01 00:00:00

  • Molecular targets for steroids in airway vascular smooth muscle.

    abstract::The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Usi...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331337559

    authors: Horvath G,Wanner A

    更新日期:2003-10-01 00:00:00

  • Perceptions of Caribbean type 2 diabetes patients on self-monitoring of blood glucose.

    abstract:CONTEXT:The views of type 2 diabetes (T2DM) patients have not been considered in the debate on the role of self-monitoring of blood glucose (SMBG) in the management of T2DM. OBJECTIVE:To assess the views of T2DM patients on SMBG. METHODS:Two previously trained research assistants used a structured pre-tested question...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.625950

    authors: Ezenwaka CE,Olukoga A,Onuoha P,Worrell R,Skinner T,Mayers H,Martin E,Phillip C

    更新日期:2012-02-01 00:00:00

  • Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods.

    abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.104.6.752.12911

    authors: Hess GP

    更新日期:1996-10-01 00:00:00

  • Renal excretion and saline intake during post-stress immobilization period in rats.

    abstract::An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/1381345520000710831zft268

    authors: Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

    更新日期:2000-07-01 00:00:00

  • Mechanoreceptors in the glabrous skin of the human hand.

    abstract::Since the first systematic analysis concerning the functional properties of mechanoreceptors in the glabrous skin of the human hand was made in 1970, the amount of available data has grown tremendously. Whereas the first research in the seventies was aimed at achieving a standard functional description of the mechanor...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/13813455199908107041qft338

    authors: Pasterkamp E

    更新日期:1999-10-01 00:00:00

  • Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway.

    abstract:OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1874017

    authors: A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi S

    更新日期:2021-01-20 00:00:00

  • Aberrant methylation of miR-124 upregulates DNMT3B in colorectal cancer to accelerate invasion and migration.

    abstract::The dysregulation of microRNA expression is significantly associated with the initiation and development of CRC. miR-124 is markedly downregulated in colorectal cancer. In the present study, the effects of methylation, over expression and downregulation of miR-124 and its target gene DNMT3B on the proliferation, migra...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1779311

    authors: Shahmohamadnejad S,Nouri Ghonbalani Z,Tahbazlahafi B,Panahi G,Meshkani R,Emami Razavi A,Shokri Afra H,Khalili E

    更新日期:2020-06-18 00:00:00

  • Mechanistic exploration of the activities of poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma at cellular and molecular levels.

    abstract::The effectiveness of betulinic acid (B) and PLGA loaded nanoparticles of B (Bnp) against hepatocellular carcinoma (HCC) was established and reported earlier. In continuation of our previous report, the present study described the molecular mechanisms of their antineoplastic responses. In this context, the antineoplast...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1733024

    authors: Kumar P,Gautam AK,Kumar U,Bhadauria AS,Singh AK,Kumar D,Mahata T,Maity B,Bera H,Saha S

    更新日期:2020-03-06 00:00:00

  • Biochanin A, a soy isoflavone, diminishes insulin resistance by modulating insulin-signalling pathway in high-fat diet-induced diabetic mice.

    abstract:AIM:The objective of this study was to evaluate the probable mechanism of action of Biochanin A (BCA) on high-fat diet-induced insulin resistance mice. METHODS:Twenty-four male C57/BL/6J mice were divided into two and fed either control diet or a high fat-high diet (HFD). After 6 weeks, mice were grouped into: Control...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1820525

    authors: Arjunan S,Thangaiyan R,Balaraman D

    更新日期:2020-09-29 00:00:00

  • Each of the four intracellular cysteines of CD36 is essential for insulin- or AMP-activated protein kinase-induced CD36 translocation.

    abstract::Stimulation of cellular fatty acid uptake by induction of insulin signalling or AMP-kinase (AMPK) activation is due to translocation of the fatty acid-transporter CD36 from intracellular stores to the plasma membrane (PM). For investigating the role of the four Cys-residues within CD36's cytoplasmic tails in CD36 tran...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2013.876049

    authors: van Oort MM,Drost R,Janβen L,Van Doorn JM,Kerver J,Van der Horst DJ,Luiken JJ,Rodenburg KC

    更新日期:2014-02-01 00:00:00

  • Effect of curcuma on zinc, lipid profile and antioxidants levels in blood and tissue of streptozotocin-induced diabetic rats fed zinc deficiency diet.

    abstract::Due to the importance of zinc as an antioxidant and its crucial role in insulin synthesis, its deficiency may affect adversely diabetic state. So, this study aimed to modulate these effects using Curcuma longa as natural antioxidant. Rats were divided into four groups: two groups fed a zinc sufficient diet one non-dia...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1623820

    authors: Tebboub I,Kechrid Z

    更新日期:2019-06-19 00:00:00

  • Melatonin reverses depressive and anxiety like-behaviours induced by diabetes: involvement of oxidative stress, age, rage and S100B levels in the hippocampus and prefrontal cortex of rats.

    abstract::Diabetes is associated with depression and anxiety symptoms. The current investigation was designed to explore the effect of melatonin on depressive and anxiety like-behaviours, oxidative stress, levels of AGE, RAGE and S100B in streptozotocin-induced diabetic rats. The animals were divided into four groups: Normoglyc...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1684954

    authors: Ergenc M,Ozacmak HS,Turan I,Ozacmak VH

    更新日期:2019-11-15 00:00:00

  • Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity.

    abstract::An important role in the regulation of glucose homeostasis is played by incretins, which are gut-derived hormones released in response to nutrient ingestion. In humans, the major incretin hormones are glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP), and together they fully account ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.3109/13813455.2013.812664

    authors: Opinto G,Natalicchio A,Marchetti P

    更新日期:2013-10-01 00:00:00

  • Effects of morphine and naloxone on glucose metabolism in uterine strips from ovariectomized and non-ovariectomized restricted diet rats.

    abstract::The effect of underfeeding over glucose metabolism in uteri isolated from ovariectomized and non-ovariectomized rats subjected to a restricted diet for 25 days (50% of the normal food intake), was studied. Underfeeding decreases (14)CO(2) formation from U(14) C-glucose in intact animal uteri. While in ovariectomized r...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.108.5.422.4295

    authors: Campos ML,Casalino-Matsuda SM,Linares JA,Goldraij A

    更新日期:2000-12-01 00:00:00

  • Striate, extrastriate and collicular processing of spatial disparity cues.

    abstract::The spatial disparity sensitivity of single units in the primary visual cortex (17-18 border), in extrastriate area 19 and in the superficial layers of the superior colliculus of the cat brain were compared in the present study. Unit recordings were performed in paralyzed and anesthetized animals. Centrally located re...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.106.3.236.4376

    authors: Bacon BA,Lepore F,Guillemot JP

    更新日期:1998-07-01 00:00:00

  • Reference spectra from squamous epithelium and connective tissue allow whole section proteomics analysis.

    abstract::We reasoned that micro-dissection of tumour cells for protein expression studies should be omitted since tumour-stroma interactions are an important part of the biology of solid tumours. To study such interactions in head and neck squamous cell carcinoma (HNSCC) development, we generated reference protein spectra for ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.525240

    authors: Roesch-Ely M,Schnölzer M,Nees M,Plinkert PK,Bosch FX

    更新日期:2010-10-01 00:00:00

  • Looking at proteins from two dimensions: a review on five decades of 2D electrophoresis.

    abstract::Separating proteins according to two different gel-electrophoretic methods not only increases the resolution power for highly complex samples when compared to one-dimensional separations, but is also a valuable tool for protein and protein complex characterization. There are a number of different electrophoresis metho...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.3109/13813455.2014.945188

    authors: Westermeier R

    更新日期:2014-12-01 00:00:00

  • Can 5-azacytidine convert the adult stem cells into cardiomyocytes? A brief overview.

    abstract::From the first report that bone marrow cells (BMC) have stem cells characteristics, several studies have debated the possibility of intervening in myocardial remodeling after injury, for example myocardial infarction, by using BMC. The goal of this paper is to review the concept of whether the demethylating agent 5-az...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1080/13813450601094631

    authors: Burlacu A

    更新日期:2006-10-01 00:00:00