Mechanistic exploration of the activities of poly(lactic-co-glycolic acid)-loaded nanoparticles of betulinic acid against hepatocellular carcinoma at cellular and molecular levels.

Abstract:

:The effectiveness of betulinic acid (B) and PLGA loaded nanoparticles of B (Bnp) against hepatocellular carcinoma (HCC) was established and reported earlier. In continuation of our previous report, the present study described the molecular mechanisms of their antineoplastic responses. In this context, the antineoplastic properties of both B and Bnp were evaluated on DEN-induced HCC rat model. The quantitative real-time polymerase chain reaction and western blot analyses revealed that HCC was developed through lower expressions of e-NOS, BAX, BAD, Cyt C and higher expressions of i-NOS, Bcl-xl, Bcl-2. B and Bnp normalised the expressions of these apoptogenic markers. Particularly, both activated i-NOS and e-NOS mediated Bcl-2 family proteins→CytC→Caspase 3 and 9 signalling cascades. The 1H-NMR-based metabolomics study also demonstrated that the perturbed metabolites in DEN-induced rat serum restored to the normal level following both treatments. Moreover, the antineoplastic potential of Bnp was found to be comparable with the marketed product, 5-flurouracil.

journal_name

Arch Physiol Biochem

authors

Kumar P,Gautam AK,Kumar U,Bhadauria AS,Singh AK,Kumar D,Mahata T,Maity B,Bera H,Saha S

doi

10.1080/13813455.2020.1733024

subject

Has Abstract

pub_date

2020-03-06 00:00:00

pages

1-13

eissn

1381-3455

issn

1744-4160

pub_type

杂志文章
  • Relationship of biochemical parameters, BMI and blood pressure with age, gender and ethnicity of Trinidadian type 2-diabetic subjects.

    abstract:OBJECTIVE:To determine the relationship of biochemical parameters, BMI and blood pressure with age, gender and ethnicity of Trinidadian type 2-diabetic subjects. METHODS:A retrospective case control study comprised of 1794 patient (740 males and 1054 females). RESULTS:The correlation was found for lipid profile with ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.613482

    authors: Nayak BS,Maharaj N,Fatt LA,Legall G

    更新日期:2012-02-01 00:00:00

  • Mass spectrometry-based proteomics and its potential use in haematological research.

    abstract::In the last decade proteomics has made great progress reaching throughput and comprehensiveness comparable to genomics technologies. Mass spectrometry plays a key role in proteomics and has become an indispensable method for molecular and cellular biology because many cellular changes in response to internal or extern...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.3109/13813450903428086

    authors: Fröbel J,Lehr S,Haas R,Czibere A

    更新日期:2009-12-01 00:00:00

  • Mammalian gonadotropin-releasing hormone (GnRH) receptor subtypes.

    abstract::Mammalian gonadotropin-releasing hormone (GnRH I) is a hypothalamic decapeptide that governs gonadotropin secretion through interaction with its seven transmembrane (7TM), G protein-coupled receptor (GPCR) expressed by anterior pituitary cells. A second decapeptide, GnRH II, originally discovered in the chicken hypoth...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.110.1.129.900

    authors: Neill JD

    更新日期:2002-04-01 00:00:00

  • Ezetimibe attenuates experimental diabetes and renal pathologies via targeting the advanced glycation, oxidative stress and AGE-RAGE signalling in rats.

    abstract::The current in-vivo study was premeditated to uncover the protective role of ezetimibe (EZ) against advanced glycation endproducts (AGEs)-related pathologies in experimental diabetes. Our results showed that EZ markedly improved the altered biochemical markers of diabetes mellitus (DM) (FBG, HbA1c, insulin, microalbum...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1874996

    authors: Nabi R,Alvi SS,Shah A,Chaturvedi CP,Faisal M,Alatar AA,Ahmad S,Khan MS

    更新日期:2021-01-29 00:00:00

  • Effect of carnosine on erythrocyte deformability in diabetic rats.

    abstract::It is known that oxidative stress plays an important role in the chronic complications of diabetes. Lipid peroxidation is one of the consequences of oxidative stress. Erythrocyte deformability abilities are reduced as a result of lipid peroxidation. Conversely, a decrease nitric oxide (NO) production seems to be respo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2012.714790

    authors: Yapislar H,Aydogan S

    更新日期:2012-12-01 00:00:00

  • Expression of metallothioneins I and II related to oxidative stress in the liver of aluminium-treated rats.

    abstract::Hepatotoxicity, induced by aluminium chloride (AlCl3), has been well studied but there are no reports about liver metallothionein (MT) genes induction. Therefore, it is of interest to establish the mechanism involving the relation between MT gene expression levels and the oxidative stress status in hepatic cells of al...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2016.1187176

    authors: Ghorbel I,Chaabane M,Elwej A,Boudawara O,Abdelhedi S,Jamoussi K,Boudawara T,Zeghal N

    更新日期:2016-10-01 00:00:00

  • Renal excretion and saline intake during post-stress immobilization period in rats.

    abstract::An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/1381345520000710831zft268

    authors: Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

    更新日期:2000-07-01 00:00:00

  • Biochanin A, a soy isoflavone, diminishes insulin resistance by modulating insulin-signalling pathway in high-fat diet-induced diabetic mice.

    abstract:AIM:The objective of this study was to evaluate the probable mechanism of action of Biochanin A (BCA) on high-fat diet-induced insulin resistance mice. METHODS:Twenty-four male C57/BL/6J mice were divided into two and fed either control diet or a high fat-high diet (HFD). After 6 weeks, mice were grouped into: Control...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1820525

    authors: Arjunan S,Thangaiyan R,Balaraman D

    更新日期:2020-09-29 00:00:00

  • Nandrolone modulates the non-opioid and opioid analgesia and tolerance/dependence: role of sexual dimorphism.

    abstract::The aim of this investigation was to study the effect of the doping steroid nandrolone on metamizol and morphine-induced analgesia and tolerance/dependence in rats. Nandrolone per se did not change the basal nociceptive thresholds in both sexes. It diminished the analgesic effect of metamizol in females, revealed by t...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331342283

    authors: Philipova T,Ivanova T,Pavlova E,Kasakov L,Vlaskovska M

    更新日期:2003-12-01 00:00:00

  • Lipid modifications of microsomes isolated from villus and crypt zones of bovine intestinal mucosa: relationship with fatty acid binding protein.

    abstract::The present studies were conducted to examine the fatty acid composition of microsomal lipids of bovine small intestine. Microsomes and cytosol were isolated from mucosal scrapings enriched with villus and crypts cells, and the following studies were conducted to: 1) analyse fatty acids from microsomal lipids; 2) inco...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.1.86.13147

    authors: Furlan L,Catala A

    更新日期:1997-02-01 00:00:00

  • Sevoflurane attenuates cognitive dysfunction and NLRP3-dependent caspase-1/11-GSDMD pathway-mediated pyroptosis in the hippocampus via upregulation of SIRT1 in a sepsis model.

    abstract::Septic encephalopathy (SE) is a devastating consequence of sepsis, a hyper-triggered host response against infectious challenge, which ultimately leads to brain damage. The present study examined whether sevoflurane (SVF), a volatile anaesthetic, can counteract the perturbation of homeostasis in a caecal ligation and ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1773860

    authors: Chen H,Peng Y,Wang L,Wang X

    更新日期:2020-06-13 00:00:00

  • [Analysis of iodine compounds in young rat skin in the period of suckling and in the adult. Effect of perchlorate].

    abstract::In the suckling and adult rats equilibrated or no by 125I, cutaneous iodine analysed by dialysis and chromatography techniques (Dowex and Sephadex) was the purpose of this study. Dialysis studies had shown that most of steady or labelled skin iodine had an iodide form (90 to 95% of the total iodine). There were at lea...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813459509047146

    authors: Zeghal N,Redjem M,Gondran F,Vigouroux E

    更新日期:1995-08-01 00:00:00

  • Divalent cation-activated ecto-ATPase activity of rat glomerular mesangial cells.

    abstract::Evidence is presented of a Mg2+ and Ca(2+)-activated ATPase at the surface of cultured rat glomerular mesangial cells. Substrate specificity was very low when different nucleoside-5'-triphosphates were examined. The apparent Km values were 0.46 and 0.32 mM for Mg(2+)-ATPase and Ca(2+)-ATPase, respectively. Inhibition ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813459509007557

    authors: Stefanović V,Vlahović P

    更新日期:1995-04-01 00:00:00

  • The modulatory effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.

    abstract::Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of a...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1722706

    authors: Ozcan S,Ulker N,Bulmus O,Yardimci A,Ozcan M,Canpolat S

    更新日期:2020-02-06 00:00:00

  • Abnormalities of the cardiac stem and progenitor cell compartment in experimental and human diabetes.

    abstract::Diabetic cardiomyopathy consists of a series of structural and functional changes. Accumulating evidence supports the concept that a "cardiac stem cell compartment disease" plays an important role in the pathophysiology of diabetic cardiomyopathy. In diabetic hearts, human cardiac stem/progenitor cells (CSPC) are redu...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.3109/13813455.2013.798334

    authors: Leonardini A,Avogaro A

    更新日期:2013-10-01 00:00:00

  • The effects of spinosad on antioxidant system and cognitive performance of mice.

    abstract::Introduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a signif...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1623264

    authors: Acar A,Akkoc H,Erdinc M

    更新日期:2019-06-07 00:00:00

  • Body position and the neuroendocrine response to insulin-induced hypoglycemia in healthy subjects.

    abstract::Changes in body fluid distribution are known to influence neuroendocrine function. The aim of the present study was to test the hypothesis that changes in plasma volume affect the counterregulatory neuroendocrine response to hypoglycemia. The tests were performed in 12 subjects in two situations: 'head-up' (+60 degree...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331337658

    authors: Radikova Z,Penesova A,Jezova D,Kvetnansky R,Vigas M,Macho L,Koska J

    更新日期:2003-10-01 00:00:00

  • Isolation of cells from ovine fetal long bone and characterization of their osteoblastic activities during in vitro mineralization.

    abstract::Studies about bone formation and regulation are complex due to a close relationship between bone cells. Primary cell cultures allow to understand osteoblastic function. We isolated cells from the cortical metacarpal bone of 85 or 120 day-old ovine fetuses by an enzymatic method. After first passage and cell amplificat...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.2.158.12924

    authors: Collignon H,Davicco MJ,Barlet JP

    更新日期:1997-04-01 00:00:00

  • Biomechanical events in the time to exhaustion at maximum aerobic speed.

    abstract::Recent studies reported good intra-individual reproducibility, but great inter-individual variation in a sample of elite athletes, in time to exhaustion (tlim) at the maximal aerobic speed (MAS: the lowest speed that elicits VO2max in an incremental treadmill test). The purpose of the present study was, on the one han...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.6.583.3272

    authors: Gazeau F,Koralsztein JP,Billat V

    更新日期:1997-10-01 00:00:00

  • Age-dependent detection of erythrocytes glucose-6-phosphate dehydrogenase and its correlation with oxidative stress.

    abstract:CONTEXT:Glucose-6-phosphate dehydrogenase (G6PD) is an important enzyme of hexose monophosphate shunt, involved in the biosynthesis of reduced nicotinamide adenine dinucleotide phosphate hydrogen (NADPH). OBJECTIVE:This study was designed to investigate age-dependent changes in human erythrocyte G6PD activity. The G6P...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2015.1136648

    authors: Maurya PK,Kumar P,Chandra P

    更新日期:2016-01-01 00:00:00

  • Soluble RAGE, diabetic nephropathy and genetic variability in the AGER gene.

    abstract::Diabetes mellitus, especially when complicated with decline of renal function due to diabetic nephropathy (DN), is associated with accumulation of advanced glycation end products (AGEs) exerting their adverse effects via receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibit...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813450802033818

    authors: Kanková K,Kalousová M,Hertlová M,Krusová D,Olsovský J,Zima T

    更新日期:2008-04-01 00:00:00

  • Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue.

    abstract::The G0/G1 switch gene 2 (G0S2) protein attenuated adipose triglyceride lipase (ATGL) activity and decreased lipolysis in rodent and human adipocytes. We hypothesized that G0S2 mRNA expression in human adipose tissue is influenced by depot, adipocyte size, body weight and caloric intake. Adipose tissue samples were obt...

    journal_title:Archives of physiology and biochemistry

    pub_type: 临床试验,杂志文章

    doi:10.3109/13813455.2015.1122066

    authors: Skopp A,May M,Janke J,Kielstein H,Wunder R,Flade-Kuthe R,Kuthe A,Jordan J,Engeli S

    更新日期:2016-01-01 00:00:00

  • Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods.

    abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.104.6.752.12911

    authors: Hess GP

    更新日期:1996-10-01 00:00:00

  • Nutrition in the management of type 2 diabetes mellitus: review.

    abstract::Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. In recent years, numerous effective T2DM intervention regimens have been developed, with promising results. However, these regimens are not usually economically available, and they are not well tolerate...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1657899

    authors: El-Tantawy WH

    更新日期:2019-09-02 00:00:00

  • Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals.

    abstract::Aim: This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods: Male infertility was induced in rat by intrape...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1645698

    authors: Ghareeb DA,Abd-Elgwad A,El-Guindy N,Yacout G,Zaatout HH

    更新日期:2019-07-31 00:00:00

  • Glycosylated rat prolactin: isolation and structural characterization.

    abstract::Isolation of glycosylated 26 kDa rat prolactin and subsequent proper carbohydrate characterization has so far not been reported. In the present work the hormone isoform was isolated to 95% homogeneity by preparative electrophoretic separation on Mini Prep Cell of rat pituitary homogenate. The isoform was then investig...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.109.2.180.4276

    authors: Bollengier F,Mahler A,Braet C,Claeyssens M,Vanhaelst L

    更新日期:2001-04-01 00:00:00

  • Spermatogenesis and steroidogenesis disruption in a model of metabolic syndrome rats.

    abstract:CONTEXT:Metabolic syndrome (MetS) is a clustering of several physiological alterations. OBJECTIVE:This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. MATERIALS AND METHODS:We developed a MetS rodent model using high-sugar and high-fat diet. RESULTS:MetS rats showed se...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1812665

    authors: Rahali D,Dallagi Y,Hupkens E,Veegh G,Mc Entee K,Asmi ME,El Fazaa S,El Golli N

    更新日期:2020-09-04 00:00:00

  • Adipokines enhance oleic acid-induced proliferation of vascular smooth muscle cells by inducing CD36 expression.

    abstract::Adipose tissue is not only releasing lipids but also various adipokines that are both dysregulated in the obese state and may contribute to obesity-associated vascular dysfunction and cardiovascular risk. We have previously shown that the combination of adipocyte-conditioned medium (CM) and oleic acid (OA) increases p...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2015.1045520

    authors: Schlich R,Lamers D,Eckel J,Sell H

    更新日期:2015-01-01 00:00:00

  • Associations between polymorphisms in VDR gene and the risk of osteoporosis: a meta-analysis.

    abstract::The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1787457

    authors: Jiang LL,Zhang C,Zhang Y,Ma F,Guan Y

    更新日期:2020-08-06 00:00:00

  • Inhibition of notch signalling and mesangial expansion by combined glucagon like peptide-1 agonist and crocin therapy in animal model of diabetic nephropathy.

    abstract::Diabetic nephropathy (DN) is one of the devastating complications in diabetes mellitus (DM). Glucagon-like peptide-1 (GLP-1) is one of the incretins secreted from L cells in the intestine. Crocin (a carotenoid component of saffron) has antioxidants properties. We investigated the renal effects of Exendin-4 as a GLP-1 ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1846203

    authors: Amin SN,El-Gamal EM,Rashed LA,Kamar SS,Haroun MA

    更新日期:2020-12-07 00:00:00