Evolocumab, a PCSK9 inhibitor, protects human endothelial cells against H2O2-induced oxidative stress.

abstract：:Folliculo-stellate cells (FS-cells) in the anterior pituitary gland are star-shaped cells and form tiny follicles. FS-cells are positive for S-100 protein and produce many cytokines or growth factors, such as interleukin-6 (IL-6), leukemia inhibitory factor (LIF), basic fibroblastic growth factor (bFGF) and vascular e...

journal_title：Archives of physiology and biochemistry

authors： Inoue K,Mogi C,Ogawa S,Tomida M,Miyai S

更新日期：2002-04-01 00:00:00

abstract：:In the suckling rats, orally provided spermine induced structural and biochemical changes in the intestine, which are characteristics of the postnatal maturation. This induced maturation was compared to that occurring spontaneously. Eight mumol spermine were administered orally once a day, for one or three days, to su...

journal_title：Archives of physiology and biochemistry

authors： Peulen O,Pirlet C,Klimek M,Goffinet G,Dandrifosse G

更新日期：1998-02-01 00:00:00

abstract：:Hepatotoxicity, induced by aluminium chloride (AlCl3), has been well studied but there are no reports about liver metallothionein (MT) genes induction. Therefore, it is of interest to establish the mechanism involving the relation between MT gene expression levels and the oxidative stress status in hepatic cells of al...

journal_title：Archives of physiology and biochemistry

authors： Ghorbel I,Chaabane M,Elwej A,Boudawara O,Abdelhedi S,Jamoussi K,Boudawara T,Zeghal N

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:To assess the relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes. METHODS:Anthropometric and biochemical parameters were measured in 56 newly diagnosed type 2 diabetic men and in 56 age and body mass index (BMI) matched...

journal_title：Archives of physiology and biochemistry

authors： Sarkar PD,Choudhury AB

更新日期：2012-12-01 00:00:00

abstract：:Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an an...

journal_title：Archives of physiology and biochemistry

authors： Ould Amara-Leffad L,Ramdane H,Nekhoul K,Ouznadji A,Koceir EA

更新日期：2019-05-01 00:00:00

abstract：:Background: We aim to identify and analyze the expression of dyregulated RNAs in colorectal cancer (CRC). Methods: We selected a panel of RNAs specific to CRC composed of Nucleosome Assembly Protein 1 Like 2 (NAP1L2) mRNA, LNCRNA SNHG14 small nucleolar RNA host gene 14 (LNCRNA SNHG14) and homo sapiens microRNA-3940-5p...

journal_title：Archives of physiology and biochemistry

authors： Matboli M,Shafei AE,Ali MA,El-Din Ahmed TS,Naser M,Abdel-Rahman T,Anber N,Ali M

更新日期：2019-08-09 00:00:00

abstract：:The actions of the insulin-like growth factor (IGF)-system are controlled by six IGF-binding proteins (IGFBPs). The IGFBPs are thought to affect local effects of IGF-I and IGF-II due to higher affinity if compared to IGF-I receptors and due to cell-type specific IGFBP expression patterns. It was found in IGFBP knockou...

journal_title：Archives of physiology and biochemistry

authors： Hoeflich A,Götz W,Lichanska AM,Bielohuby M,Tönshoff B,Kiepe D

更新日期：2007-06-01 00:00:00

abstract：:Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fa...

journal_title：Archives of physiology and biochemistry

authors： Atila Uslu G,Uslu H

更新日期：2019-09-23 00:00:00

abstract：:This study aimed to investigate the roles of RPSAP52 in renal failure. Our results showed that RPSAP52 was upregulated in plasma of renal failure patients in comparison to healthy controls. Dual luciferase reporter assay showed that RPSAP52 could interact with miR-423-5p, while overexpression of RPSAP52 and miR-423-5p...

journal_title：Archives of physiology and biochemistry

authors： Chen J,Zheng Y,Li L

更新日期：2020-04-17 00:00:00

abstract：:The role of adrenoceptor subtypes was studied in rat brown adipose tissue (BAT). The type II 5'-deiodinase (5'DII) was activated in response to simultaneous stimulation by beta3- and alpha1-adrenergic agonists, BRL 37344 or CGP 12177, and cirazoline, in brown adipocytes. Inhibition of the alpha1- and beta-adrenergic p...

journal_title：Archives of physiology and biochemistry

authors： Raasmaja A,York DA

更新日期：2006-02-01 00:00:00

abstract：:Several different studies have investigated the growth effects of angiotensin II on vascular smooth muscle cells in culture. However, smooth muscle cells change their phenotype when placed in culture. The objective of the present study was to investigate the effects of angiotensin II on (3)H-thymidine and (3)H-proline...

journal_title：Archives of physiology and biochemistry

authors： Mangiarua EI,Galagedera NJ,Eastham LL

更新日期：2001-12-01 00:00:00

abstract：:The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session,...

journal_title：Archives of physiology and biochemistry

authors： Becker CU,Sartório CL,Campos-Carraro C,Siqueira R,Colombo R,Zimmer A,Belló-Klein A

更新日期：2020-05-25 00:00:00

abstract：CONTEXT:Metabolic syndrome (MetS) is a clustering of several physiological alterations. OBJECTIVE:This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. MATERIALS AND METHODS:We developed a MetS rodent model using high-sugar and high-fat diet. RESULTS:MetS rats showed se...

journal_title：Archives of physiology and biochemistry

authors： Rahali D,Dallagi Y,Hupkens E,Veegh G,Mc Entee K,Asmi ME,El Fazaa S,El Golli N

更新日期：2020-09-04 00:00:00

abstract：:The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6) is known to be released during exercise and is thought that either IL-6 directly or via a "contraction factor" stimulates the release of stored glucose from the...

journal_title：Archives of physiology and biochemistry

authors： Dent JR,Chowdhury MK,Tchijov S,Dulson D,Smith G

更新日期：2016-01-01 00:00:00

abstract：:Introduction: There are few studies examining the effect of spinosad on cognitive functions in the literature. Methods: In this study, we applied spinosad 3 weeks in different doses to mice and examined their effects on antioxidant system and cognitive performance. Results: In the open field test, we observed a signif...

journal_title：Archives of physiology and biochemistry

authors： Acar A,Akkoc H,Erdinc M

更新日期：2019-06-07 00:00:00

abstract：:Diabetes represents an important public health problem. Recently, new molecular targets have been identified and exploited to treat this disease. Due to its pivotal role in glucose homeostasis, glucokinase (GCK) is a promising target for the development of novel antidiabetic drugs; however, pharmacological agents that...

journal_title：Archives of physiology and biochemistry

authors： Guzmán TJ,Gurrola-Díaz CM

更新日期：2019-06-18 00:00:00

abstract：:Arecoline is known to cause endocrine dysfunction. In the current article role of arecoline on pineal-testis activity was investigated in hypothyroid rats induced by propylthiouracil (PTU). PTU treatment caused thyroid dysfunction ultrastructurally with a fall in T3 and T4 levels followed by a rise of thyroid stimulat...

journal_title：Archives of physiology and biochemistry

authors： Saha I,Chakraborty SB,Chatterjee A,Pradhan D,Chatterji U,Maiti BR

更新日期：2020-02-01 00:00:00

abstract：:An important role in the regulation of glucose homeostasis is played by incretins, which are gut-derived hormones released in response to nutrient ingestion. In humans, the major incretin hormones are glucagon-like peptide (GLP)-1 and glucose-dependent insulinotropic polypeptide (GIP), and together they fully account ...

journal_title：Archives of physiology and biochemistry

authors： Opinto G,Natalicchio A,Marchetti P

更新日期：2013-10-01 00:00:00

abstract：:Combining samples from a national neonatal screening programme with the information from a national health registry allow for unique opportunities in analysing newborn blood for protein changes that could predict eventual disease development. A nested case-control cohort (n = 54 cases, 108 controls) was analysed by pr...

journal_title：Archives of physiology and biochemistry

authors： McGuire JN,Eising S,Wägner AM,Pociot F

更新日期：2010-10-01 00:00:00

abstract：:Isolation of glycosylated 26 kDa rat prolactin and subsequent proper carbohydrate characterization has so far not been reported. In the present work the hormone isoform was isolated to 95% homogeneity by preparative electrophoretic separation on Mini Prep Cell of rat pituitary homogenate. The isoform was then investig...

journal_title：Archives of physiology and biochemistry

authors： Bollengier F,Mahler A,Braet C,Claeyssens M,Vanhaelst L

更新日期：2001-04-01 00:00:00

abstract：INTRODUCTION:Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE:To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in wo...

journal_title：Archives of physiology and biochemistry

authors： Koleva DI,Orbetzova MM,Nikolova JG,Tyutyundzhiev SB

更新日期：2016-10-01 00:00:00

abstract：:Pancreatic beta-cell mass expands through beta-cell proliferation and neogenesis while it decreases mainly via apoptosis. The loss of balance between beta-cell death and regeneration leads to a reduction of beta-cell functional mass, thus contributing to the pathogenesis of type 2 diabetes mellitus (T2DM). The pathoge...

journal_title：Archives of physiology and biochemistry

authors： Tortosa F,Dotta F

更新日期：2013-10-01 00:00:00

abstract：:Objective: To evaluate the effect of the administration of phytoestrogens on obesity, type 2 diabetes, and liver-kidney toxicity. Methods: Phytoestrogens (phyto(E2)) were administrated to high fructose-fat diet (HFFD). Results: This study showed that administration of phyto(E2) to HFFD-mice inhibited lipase activity b...

journal_title：Archives of physiology and biochemistry

authors： Hamden K,Boujibiha MA,Ben Abdeljelil N,Njima M,Selmi B,Achour L

更新日期：2019-12-01 00:00:00

abstract：:To investigate the antidiabetic effect of isopulegol in high-fat diet (HFD)/streptozotocin (STZ)-induced diabetic rats. Animals were made diabetic by feeding HFD for 4 weeks followed by single intraperitoneal injection of STZ (35 mg/kg b.w.; 0.1 M citrate buffer; pH 4.0). Plasma insulin, haemoglobin and glycogen conte...

journal_title：Archives of physiology and biochemistry

authors： Kalaivani K,Sankaranarayanan C

更新日期：2019-07-10 00:00:00

abstract：:Due to the importance of zinc as an antioxidant and its crucial role in insulin synthesis, its deficiency may affect adversely diabetic state. So, this study aimed to modulate these effects using Curcuma longa as natural antioxidant. Rats were divided into four groups: two groups fed a zinc sufficient diet one non-dia...

journal_title：Archives of physiology and biochemistry

authors： Tebboub I,Kechrid Z

更新日期：2019-06-19 00:00:00

abstract：:A range of epidemiological evidence from several diverse populations, supports the hypothesis that risk of essential hypertension, coronary heart disease and non-insulin dependent diabetes is, in part, programmed by intrauterine nutritional status. Animal models developed to investigate the mechanisms that are respons...

journal_title：Archives of physiology and biochemistry

authors： Langley-Evans SC,Langley-Evans AJ,Marchand MC

更新日期：2003-02-01 00:00:00

abstract：:We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individ...

journal_title：Archives of physiology and biochemistry

authors： Sezgin G,Kar F,Uslu S

更新日期：2020-06-22 00:00:00

abstract：:This research was designed to detect the function of low-density lipoprotein receptor (LDLR)-related protein 8 (LRP8) in breast cancer (BC). Our results revealed that LRP8 was highly expressed in BC tissues and cell lines compared with human normal breast tissues. The poor prognosis of patients with BC was associated ...

journal_title：Archives of physiology and biochemistry

authors： Li L,Qu WH,Ma HP,Wang LL,Zhang YB,Ma Y

更新日期：2020-01-29 00:00:00

abstract：:An experiment in which the rats access either to 0.5% or 1.5% saline was designed in order to further characterise the relationship between sodium intake and renal excretion after acute immobilization stress. A saline solution for 3 days was provided to the rats previous to the experimental day. On that day, after fin...

journal_title：Archives of physiology and biochemistry

authors： Niebylski A,Bertuzzi M,Bensi N,Armario A,Gauna HF

更新日期：2000-07-01 00:00:00

abstract：BACKGROUND:A substantial body of evidence links sex hormones, diet, excess body weight and physical activity to the risk of developing cancer at several sites common in affluent countries. The hypothesis that high circulating levels of insulin could be the underlying factor increasing cancer risk has been proposed. Epi...

journal_title：Archives of physiology and biochemistry

authors： Pisani P

更新日期：2008-02-01 00:00:00