Abstract:
:Objective: The present study aimed to investigate the effects of Juglans regia (JR) extract on hyperglycaemia and insulin sensitivity. Methods: Forty rats were divided into 4 groups: Control (C), Diabetes Control (DC), Diabetes + Juglans regia (D + JR) and Diabetes + Metformin (D + M). Results: In the D + JR group, Fasting blood glucose (FBG) levels decreased from day 14 onwards. There was a significant decrease in plasma levels of Fibronectin Type III Domain Containing 5 (FNDC5) and adiponectin (ADP) in the DC group compared to the C group (p < .01, p < .001 respectively). In the D + JR group, there was a significant increase in plasma FNDC5 and ADP (p < .05), while the plasma Tumour necrosis factor-alpha (TNF-α) levels were decreased compared to the DC group (p < .001). Conclusions: In conclusion, the present study found that JR and its bioactive components alleviated insulin resistance by increasing ADP and FNDC5 and decreasing FBG in a rat model of streptozotocin (STZ) + nicotinamide (NAD)-induced type 2 diabetes (T2D). Highlights Juglans regia extract increased insulin sensitivity. Juglans regia extract significantly reduced the level of fasting blood glucose. Juglans regia extract reduced TNF-α levels in rats with type 2 diabetes. Juglans regia extract prevent weight loss in type 2 diabetes.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Atila Uslu G,Uslu Hdoi
10.1080/13813455.2019.1668018subject
Has Abstractpub_date
2019-09-23 00:00:00pages
1-5eissn
1381-3455issn
1744-4160pub_type
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