A novel biomarker explaining the role of oxidative stress in exercise and l-tyrosine supplementation: thiol/disulphide homeostasis.

Abstract:

:The present study aimed to evaluate the relationship between exercise and both l-tyrosine and oxidative stress using thiol/disulphide homeostasis via a novel biomarker in rats. Following the completion of the exercise and l-tyrosine protocol, serum total thiol, native thiol, and disulphide concentrations were determined using a novel automated measurement method. Compared with the control group, serum dynamic disulphide levels were significantly lower in the E group (116.75 ± 10.49; p < .05) and the highest in the LT group (151.0 ± 5.84). The lowest oxidised thiol (49.75 ± 6.18; p = .087) and the highest reduced thiol (75.38 ± 3.16; p = .079) rates were determined to be in the E group. The highest oxidised thiol value was observed in the LT group. Exercise positively affects thiol/disulphide homeostasis, which is a novel indicator of oxidant-antioxidant parameters. Additionally, l-tyrosine appears to be more convenient combined with exercise. The new method used in our study proposes a promising, practical, and useful method for assessing the oxidative stress parameters.

journal_name

Arch Physiol Biochem

authors

Kayacan Y,Yazar H,Kisa EC,Ghojebeigloo BE

doi

10.1080/13813455.2017.1388410

subject

Has Abstract

pub_date

2018-07-01 00:00:00

pages

232-236

issue

3

eissn

1381-3455

issn

1744-4160

journal_volume

124

pub_type

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