Abstract:
:This study was to investigate whether epidermal growth factor (EGF) may induce any long-term effect on pancreatic exocrine function in vivo as well to evaluate the chronic effects of EGF on pancreatic growth in rats. Rats were treated with EGF (10 micrograms/kg) for 5 or 7 days. EGF infused intravenously (2 micrograms/kg/h) in anaesthetized and pretreated rats for 5 or 7 days with EGF caused a slight decline flow rate after 1 h of EGF infusion compared to control values. In contrast, EGF evoked a increase in amylase secretion. This stimulatory effect was much larger in EGF-pretreated rats for 7 days, whereas the total protein output was unchanged. The trophic parameters which include pancreatic weight, total protein and total contents of DNA and RNA relative to body weight were not significantly different in any treated group. Only the pancreatic amylase content was increased significantly after 7 days of treatment with EGF. The present study fails to observe a stimulatory role of EGF on pancreatic growth in rats, but may participate in the regulation of pancreatic exocrine function in vivo.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Lajas AI,Pozo MJ,Salido GM,Singh J,Pariente JAdoi
10.1076/apab.104.3.293.12909subject
Has Abstractpub_date
1996-01-01 00:00:00pages
293-9issue
3eissn
1381-3455issn
1744-4160journal_volume
104pub_type
杂志文章abstract::Several studies have suggested that fibroblast-like synoviocytes (FLSs) and miRNAs are implicated in the pathogenesis of rheumatoid arthritis (RA). This study was aimed to evaluate the function of miR-6089 in the regulation of RA-FLSs. The levels of miR-6089 were detected to be significantly lower in the synovial tiss...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1773862
更新日期:2020-06-17 00:00:00
abstract:CONTEXT:Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE:This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS:Th...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2017.1347689
更新日期:2017-12-01 00:00:00
abstract::Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1716017
更新日期:2020-01-25 00:00:00
abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.104.6.752.12911
更新日期:1996-10-01 00:00:00
abstract::The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session,...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1769679
更新日期:2020-05-25 00:00:00
abstract:CONTEXT:Metabolic syndrome (MetS) is a clustering of several physiological alterations. OBJECTIVE:This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. MATERIALS AND METHODS:We developed a MetS rodent model using high-sugar and high-fat diet. RESULTS:MetS rats showed se...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1812665
更新日期:2020-09-04 00:00:00
abstract::Type 2 Diabetes mellitus (T2D) is the most common endocrine disorder associated to metabolic syndrome (MS) and occurs when insulin secretion can no compensate peripheral insulin resistance. Among peripheral tissues, the liver controls glucose homeostasis due to its ability to consume and produce glucose. The molecular...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2011.557386
更新日期:2011-07-01 00:00:00
abstract::Dopamine (DA) is thought to modulate the transduction of the hypoxic stimulus by the glomus cell in the carotid body (CB). The hypothesis tested here is that presynaptic DA D2 receptors (D2's) located on the type 1 cell function as autoreceptors to control DA release and/or synthesis. The aim of the study was to compa...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.105.1.3.13145
更新日期:1997-02-01 00:00:00
abstract::Context: Small peptides as multifunctional biomolecules can prevent the metabolic disorders such as diabetes. Objective: The purpose of this study was to investigate the effects of small peptides on the enzymes and histopathology of the liver in mice exposed to diabetes. Methods: Di- and tri-peptides containing prolin...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1662453
更新日期:2019-09-09 00:00:00
abstract::Background: We aim to identify and analyze the expression of dyregulated RNAs in colorectal cancer (CRC). Methods: We selected a panel of RNAs specific to CRC composed of Nucleosome Assembly Protein 1 Like 2 (NAP1L2) mRNA, LNCRNA SNHG14 small nucleolar RNA host gene 14 (LNCRNA SNHG14) and homo sapiens microRNA-3940-5p...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1650070
更新日期:2019-08-09 00:00:00
abstract::Antisense oligonucleotides (ODN) are potent molecules that could be used to inhibit the synthesis of a protein specifically if delivered to the appropriate compartments (cytoplasm and nucleus) of the cell under study. We present here a simple method providing access to the fractions of internalized ODN available in th...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.111.3.265.23465
更新日期:2003-07-01 00:00:00
abstract::This study investigated the effect of eight weeks of aerobic training (AT) combined with silymarin (S)consumption on glycemic indices and liver enzymes in men with type 2 diabetes (T2D). In this clinical trial, 60 middle-aged male volunteers were randomly divided into 4 groups, including: (1) C + placebo(C) (2) AT + p...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1797104
更新日期:2020-08-04 00:00:00
abstract::A range of epidemiological evidence from several diverse populations, supports the hypothesis that risk of essential hypertension, coronary heart disease and non-insulin dependent diabetes is, in part, programmed by intrauterine nutritional status. Animal models developed to investigate the mechanisms that are respons...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.1076/apab.111.1.8.15136
更新日期:2003-02-01 00:00:00
abstract::We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1779310
更新日期:2020-06-22 00:00:00
abstract::Several different studies have investigated the growth effects of angiotensin II on vascular smooth muscle cells in culture. However, smooth muscle cells change their phenotype when placed in culture. The objective of the present study was to investigate the effects of angiotensin II on (3)H-thymidine and (3)H-proline...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.109.5.404.11827
更新日期:2001-12-01 00:00:00
abstract:CONTEXT:The views of type 2 diabetes (T2DM) patients have not been considered in the debate on the role of self-monitoring of blood glucose (SMBG) in the management of T2DM. OBJECTIVE:To assess the views of T2DM patients on SMBG. METHODS:Two previously trained research assistants used a structured pre-tested question...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2011.625950
更新日期:2012-02-01 00:00:00
abstract::The current in-vivo study was premeditated to uncover the protective role of ezetimibe (EZ) against advanced glycation endproducts (AGEs)-related pathologies in experimental diabetes. Our results showed that EZ markedly improved the altered biochemical markers of diabetes mellitus (DM) (FBG, HbA1c, insulin, microalbum...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2021.1874996
更新日期:2021-01-29 00:00:00
abstract::The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally ...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1787457
更新日期:2020-08-06 00:00:00
abstract::The powerful vasoconstrictor peptide endothelin-1 (ET1) has been shown to reduce local cerebral blood flow in brain areas supplied by the middle cerebral artery (MCA) to a pathologically low level upon intracerebral injection adjacent to the MCA. This reduction manifests itself as an ischemic infarct, that is fully de...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.106.5.384.4362
更新日期:1998-12-01 00:00:00
abstract::The effect of underfeeding over glucose metabolism in uteri isolated from ovariectomized and non-ovariectomized rats subjected to a restricted diet for 25 days (50% of the normal food intake), was studied. Underfeeding decreases (14)CO(2) formation from U(14) C-glucose in intact animal uteri. While in ovariectomized r...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.108.5.422.4295
更新日期:2000-12-01 00:00:00
abstract::Present study investigated the interactive effect of swimming training and fenugreek on glycemic index and lipid profile of diabetic rats. Forty-eight diabetic rats were randomly assigned to (1) control(C), (2) training(T), (3) fenugreek(F), and (4) training + fenugreek(T + F) groups and 12 healthy rats were placed in...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1826529
更新日期:2020-10-05 00:00:00
abstract::In this study, we report the synthesis of novel tris-chalcones and testing of human carbonic anhydrase I, and II isoenzymes (hCA I, and hCA II), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and α-glycosidase (α-Gly) inhibitors for the development of novel chalcone structures towards for treatment of some...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2019.1623265
更新日期:2019-06-07 00:00:00
abstract::Separating proteins according to two different gel-electrophoretic methods not only increases the resolution power for highly complex samples when compared to one-dimensional separations, but is also a valuable tool for protein and protein complex characterization. There are a number of different electrophoresis metho...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章,评审
doi:10.3109/13813455.2014.945188
更新日期:2014-12-01 00:00:00
abstract::The dysregulation of microRNA expression is significantly associated with the initiation and development of CRC. miR-124 is markedly downregulated in colorectal cancer. In the present study, the effects of methylation, over expression and downregulation of miR-124 and its target gene DNMT3B on the proliferation, migra...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1779311
更新日期:2020-06-18 00:00:00
abstract:OBJECTIVE:The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis. METHODS:This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum. RESULTS:The...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2011.645545
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To assess the relationship of serum osteocalcin levels with blood glucose, insulin resistance and lipid profile in central Indian men with type 2 diabetes. METHODS:Anthropometric and biochemical parameters were measured in 56 newly diagnosed type 2 diabetic men and in 56 age and body mass index (BMI) matched...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.3109/13813455.2012.715651
更新日期:2012-12-01 00:00:00
abstract::Investigations were undertaken to obtain information on the mechanism by which orally administered spermine induces postnatal maturation in the rat intestine. Suckling rats ingested one dose of spermine (8 mumol) then were sacrificed at different intervals. -A. Proximal and distal parts of the intestine were homogenis...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.104.2.163.12886
更新日期:1996-01-01 00:00:00
abstract::We investigated the effects of tauroursodeoxycholic acid (TUDCA) to assess whether this acid may also have "protective" effects similar to those found with ursodeoxycholic acid (UDCA). We used a well-known amphibian model of gastric mucosa, and studied the effects of taurodeoxycholic acid (TDCA) on electrical transepi...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1076/apab.110.3.197.8295
更新日期:2002-07-01 00:00:00
abstract::Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of a...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1722706
更新日期:2020-02-06 00:00:00
abstract:AIM:A high-fat diet (HFD) can lead to obesity and related metabolic disorders. This study evaluated the preventive efficacy of myricetin derivative-rich fraction (MD) from Syzygium malaccense leaf extract against HFD-induced obesity, hyperglycaemia, and oxidative stress in C57BL/6J mice. METHODS:HFD-fed mice were admi...
journal_title:Archives of physiology and biochemistry
pub_type: 杂志文章
doi:10.1080/13813455.2020.1808019
更新日期:2020-08-19 00:00:00