MiRNA-6089 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targeting CCR4.

abstract：:Objective: We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM).Material and Methods: The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, ...

journal_title：Archives of physiology and biochemistry

authors： Kısa B,Sert UY,Celik HK,Candar T,Erol Koç EM,Taşcı Y,Çağlar GS

更新日期：2020-03-19 00:00:00

abstract：:This study investigates the effects of the islet hormones insulin (Ins), glucagon (Glu), and somatostatin (Som) with nerve stimulation (EFS) acetylcholine (ACh) and cholecytokinin-octapeptide (CCK-8) on amylase secretion and intracellular free calcium concentration [Ca(2+)](i) in the pancreas of age-matched control an...

journal_title：Archives of physiology and biochemistry

authors： Singh J,Yago MD,Adeghate E

更新日期：2001-07-01 00:00:00

abstract：:In the last decade proteomics has made great progress reaching throughput and comprehensiveness comparable to genomics technologies. Mass spectrometry plays a key role in proteomics and has become an indispensable method for molecular and cellular biology because many cellular changes in response to internal or extern...

journal_title：Archives of physiology and biochemistry

authors： Fröbel J,Lehr S,Haas R,Czibere A

更新日期：2009-12-01 00:00:00

abstract：:Adipose tissue is a critical regulator of energy balance and substrate metabolism, and synthesizes several different substances with endocrine or paracrine functions, which regulate the overall energetic homeostasis. An excessive amount of adipose tissue has been associated with the development of type 2 diabetes, pre...

journal_title：Archives of physiology and biochemistry

authors： Laviola L,Perrini S,Cignarelli A,Giorgino F

更新日期：2006-04-01 00:00:00

abstract：:Combining samples from a national neonatal screening programme with the information from a national health registry allow for unique opportunities in analysing newborn blood for protein changes that could predict eventual disease development. A nested case-control cohort (n = 54 cases, 108 controls) was analysed by pr...

journal_title：Archives of physiology and biochemistry

authors： McGuire JN,Eising S,Wägner AM,Pociot F

更新日期：2010-10-01 00:00:00

abstract：:We investigated the effects of tauroursodeoxycholic acid (TUDCA) to assess whether this acid may also have "protective" effects similar to those found with ursodeoxycholic acid (UDCA). We used a well-known amphibian model of gastric mucosa, and studied the effects of taurodeoxycholic acid (TDCA) on electrical transepi...

journal_title：Archives of physiology and biochemistry

authors： Piepoli AL,Caroppo R,Armentano R,Caruso ML,Guerra V,Maselli MA

更新日期：2002-07-01 00:00:00

abstract：:Separating proteins according to two different gel-electrophoretic methods not only increases the resolution power for highly complex samples when compared to one-dimensional separations, but is also a valuable tool for protein and protein complex characterization. There are a number of different electrophoresis metho...

journal_title：Archives of physiology and biochemistry

authors： Westermeier R

更新日期：2014-12-01 00:00:00

abstract：:The authors conducted this meta-analysis to robustly estimate relationships between polymorphisms in VDR gene and the risk of osteoporosis by integrating the results of previous works. Medline, Embase, Wanfang, VIP and CNKI were searched thoroughly for eligible studies, and 73 genetic association studies were finally ...

journal_title：Archives of physiology and biochemistry

authors： Jiang LL,Zhang C,Zhang Y,Ma F,Guan Y

更新日期：2020-08-06 00:00:00

abstract：:Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of a...

journal_title：Archives of physiology and biochemistry

authors： Ozcan S,Ulker N,Bulmus O,Yardimci A,Ozcan M,Canpolat S

更新日期：2020-02-06 00:00:00

abstract：:The G0/G1 switch gene 2 (G0S2) protein attenuated adipose triglyceride lipase (ATGL) activity and decreased lipolysis in rodent and human adipocytes. We hypothesized that G0S2 mRNA expression in human adipose tissue is influenced by depot, adipocyte size, body weight and caloric intake. Adipose tissue samples were obt...

journal_title：Archives of physiology and biochemistry

authors： Skopp A,May M,Janke J,Kielstein H,Wunder R,Flade-Kuthe R,Kuthe A,Jordan J,Engeli S

更新日期：2016-01-01 00:00:00

abstract：:The dysregulation of microRNA expression is significantly associated with the initiation and development of CRC. miR-124 is markedly downregulated in colorectal cancer. In the present study, the effects of methylation, over expression and downregulation of miR-124 and its target gene DNMT3B on the proliferation, migra...

journal_title：Archives of physiology and biochemistry

authors： Shahmohamadnejad S,Nouri Ghonbalani Z,Tahbazlahafi B,Panahi G,Meshkani R,Emami Razavi A,Shokri Afra H,Khalili E

更新日期：2020-06-18 00:00:00

abstract：:Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS in...

journal_title：Archives of physiology and biochemistry

authors： Luo X,Yang X,Yang Y,Li H,Cui H,Cao X

更新日期：2020-07-01 00:00:00

abstract：:The effectiveness of betulinic acid (B) and PLGA loaded nanoparticles of B (Bnp) against hepatocellular carcinoma (HCC) was established and reported earlier. In continuation of our previous report, the present study described the molecular mechanisms of their antineoplastic responses. In this context, the antineoplast...

journal_title：Archives of physiology and biochemistry

authors： Kumar P,Gautam AK,Kumar U,Bhadauria AS,Singh AK,Kumar D,Mahata T,Maity B,Bera H,Saha S

更新日期：2020-03-06 00:00:00

abstract：:Context: Small peptides as multifunctional biomolecules can prevent the metabolic disorders such as diabetes. Objective: The purpose of this study was to investigate the effects of small peptides on the enzymes and histopathology of the liver in mice exposed to diabetes. Methods: Di- and tri-peptides containing prolin...

journal_title：Archives of physiology and biochemistry

authors： Mesgari-Abbasi M,Valizadeh H,Mirzakhani N,Vahdatpour T

更新日期：2019-09-09 00:00:00

abstract：:Adiponectin is the most important adipokine secreted by the adipose tissue. It carries out an important role in setting up the metabolism and improving the function of various organs. Adiponectin in the kidneys prevents degradation of the renal arteries, reduces protein excretion, and improves filtration. This role is...

journal_title：Archives of physiology and biochemistry

authors： Esmaili S,Hemmati M,Karamian M

更新日期：2020-02-01 00:00:00

abstract：:For the identification of proteins from biological samples by mass spectrometry there are two scenarios. Proteins are pre-fractionated in some way or are analysed as a complex mixture (shotgun). Shotgun proteomics recently became more popular, because of technological developments on the mass spectrometer side which n...

journal_title：Archives of physiology and biochemistry

authors： Li X,Franz T

更新日期：2014-12-01 00:00:00

abstract：:Antisense oligonucleotides (ODN) are potent molecules that could be used to inhibit the synthesis of a protein specifically if delivered to the appropriate compartments (cytoplasm and nucleus) of the cell under study. We present here a simple method providing access to the fractions of internalized ODN available in th...

journal_title：Archives of physiology and biochemistry

authors： Eboue D,Auger R,Angiari C,Le Doan T,Tenu JP

更新日期：2003-07-01 00:00:00

abstract：:Studies about bone formation and regulation are complex due to a close relationship between bone cells. Primary cell cultures allow to understand osteoblastic function. We isolated cells from the cortical metacarpal bone of 85 or 120 day-old ovine fetuses by an enzymatic method. After first passage and cell amplificat...

journal_title：Archives of physiology and biochemistry

authors： Collignon H,Davicco MJ,Barlet JP

更新日期：1997-04-01 00:00:00

abstract：:The effects of exercise training on oxidative stress in gastrocnemius of rats with pulmonary hypertension were studied. Four groups were established: sedentary control (SC), sedentary monocrotaline (SM), trained control (TC), trained monocrotaline (TM). Exercise was applied for 4 weeks, 5 days/week, 50-60 min/session,...

journal_title：Archives of physiology and biochemistry

authors： Becker CU,Sartório CL,Campos-Carraro C,Siqueira R,Colombo R,Zimmer A,Belló-Klein A

更新日期：2020-05-25 00:00:00

abstract：:Glycogen synthesis increases after muscle contraction and during insulin stimulation, and insulin-stimulated glycogen synthesis is enhanced after contraction. We hypothesized that the initial glycogen content influences the magnitude of additive effect of contraction on insulin-stimulated glycogen synthesis. Contracti...

journal_title：Archives of physiology and biochemistry

authors： Lai YC,Stuenaes JT,Kuo CH,Jensen J

更新日期：2010-07-01 00:00:00

abstract：:Phospholipid fatty acid composition and bilirubin UDP-glucuronyltransferase activity from liver microsomal membrane were studied in normal and in bile duct ligated rats. Incubation of normal microsomes with 15 microM bilirubin (considered as physiological concentration) yielded 60% bilirubin diglucuronide; in 2 days p...

journal_title：Archives of physiology and biochemistry

authors： Ouviña CB,Pavese CB,Lemberg A,Bengochea LA

更新日期：1995-08-01 00:00:00

abstract：:Recent studies reported good intra-individual reproducibility, but great inter-individual variation in a sample of elite athletes, in time to exhaustion (tlim) at the maximal aerobic speed (MAS: the lowest speed that elicits VO2max in an incremental treadmill test). The purpose of the present study was, on the one han...

journal_title：Archives of physiology and biochemistry

authors： Gazeau F,Koralsztein JP,Billat V

更新日期：1997-10-01 00:00:00

abstract：CONTEXT:Metabolic syndrome (MetS) is a clustering of several physiological alterations. OBJECTIVE:This study was designed to evaluate the effects of MetS on rats spermatogenesis and steroidogenesis. MATERIALS AND METHODS:We developed a MetS rodent model using high-sugar and high-fat diet. RESULTS:MetS rats showed se...

journal_title：Archives of physiology and biochemistry

authors： Rahali D,Dallagi Y,Hupkens E,Veegh G,Mc Entee K,Asmi ME,El Fazaa S,El Golli N

更新日期：2020-09-04 00:00:00

abstract：:The transport system for the cytokine tumor necrosis factor-alpha (TNFalpha) at the blood-brain barrier (BBB) enables an enhanced yet saturable entry of TNFalpha from blood to the CNS. This review focuses on the selective upregulation of the transport system for TNFalpha at the BBB that is specific for type of patholo...

journal_title：Archives of physiology and biochemistry

authors： Pan W,Kastin AJ

更新日期：2001-10-01 00:00:00

abstract：:Context: Recent surveys have shown an association between proprotein convertase subtilisin/kexin type 9 (PCSK9) and oxidative stress.Objective: In this investigation, the effect of evolocumab an anti-PCSK9 antibody was assessed against oxidative damage caused by hydrogen peroxide (H2O2) in human umbilical vein endothe...

journal_title：Archives of physiology and biochemistry

authors： Safaeian L,Mirian M,Bahrizadeh S

更新日期：2020-07-03 00:00:00

abstract：INTRODUCTION:Insulin resistance (IR) is closely associated with increased atherogenic risk. OBJECTIVE:To investigate leptin, adiponectin, soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1) levels and their relationship with each other and metabolic parameters in wo...

journal_title：Archives of physiology and biochemistry

authors： Koleva DI,Orbetzova MM,Nikolova JG,Tyutyundzhiev SB

更新日期：2016-10-01 00:00:00

abstract：:The mechanism underlying the increased rate of endogenous glucose production from the liver during exercise remains unknown. The cytokine interleukin-6 (IL-6) is known to be released during exercise and is thought that either IL-6 directly or via a "contraction factor" stimulates the release of stored glucose from the...

journal_title：Archives of physiology and biochemistry

authors： Dent JR,Chowdhury MK,Tchijov S,Dulson D,Smith G

更新日期：2016-01-01 00:00:00

abstract：:Evidence is presented of a Mg2+ and Ca(2+)-activated ATPase at the surface of cultured rat glomerular mesangial cells. Substrate specificity was very low when different nucleoside-5'-triphosphates were examined. The apparent Km values were 0.46 and 0.32 mM for Mg(2+)-ATPase and Ca(2+)-ATPase, respectively. Inhibition ...

journal_title：Archives of physiology and biochemistry

authors： Stefanović V,Vlahović P

更新日期：1995-04-01 00:00:00

abstract：CONTEXT:Mechanisms by which ghrelin affords its cardioprotection in mammals remained unclear. OBJECTIVE:To examine if ghrelin confers cardio-protection during cardiac remodelling post-MI by modulating the RAF-1-MEK1/2-ERK1/2 signalling pathway. MATERIALS AND METHODS:Rats were divided into control, sham, sham + ghreli...

journal_title：Archives of physiology and biochemistry

authors： Eid RA,Alkhateeb MA,Al-Shraim M,Eleawa SM,Shatoor AS,El-Kott AF,Zaki MSA,Shatoor KA,Bin-Jaliah I,Al-Hashem FH

更新日期：2019-05-01 00:00:00

abstract：:This present study investigated the antioxidative and antidiabetic properties of kolaviron by analysing its inhibitory effect on key metabolic activities linked to T2D, in vitro and ex vivo. Kolaviron significantly inhibited α-glucosidase and α-amylase activities, and intestinal glucose absorption dose-dependently, wh...

journal_title：Archives of physiology and biochemistry

authors： Salau VF,Erukainure OL,Koorbanally NA,Islam MS

更新日期：2020-08-17 00:00:00