Abstract:
:Objectives: The main aim of this study was to investigate the effects of irisin on asprosin, leptin, glucose levels and lipid profile in healthy and obese male and female rats.Methods: Irisin was subcutaneously administered with osmotic minipumps at the dose of 100 ng/kg/day for 28 days and then, the serum levels of asprosin, leptin, glucose and lipid profile were investigated.Results: Irisin infusion increased asprosin levels in male rats (p = .02) but not in female rats. Irisin inhibited obesity-induced high glucose, low-density lipoprotein (LDL), triglyceride (TG) and leptin levels in all groups; however, it did not lead to any change in asprosin levels in both obese female and male rats.Conclusions: It was determined that irisin increased serum asprosin levels and decreased LDL, TG, glucose and leptin levels, and this could indicate a protective role of irisin against obesity development.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Ozcan S,Ulker N,Bulmus O,Yardimci A,Ozcan M,Canpolat Sdoi
10.1080/13813455.2020.1722706subject
Has Abstractpub_date
2020-02-06 00:00:00pages
1-8eissn
1381-3455issn
1744-4160pub_type
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