Abstract:
CONTEXT:Essential oils from Pinus species have been reported to have various therapeutic properties. OBJECTIVE:This study was undertaken to identify the chemical composition and cytoprotective effects of the essential oil of Pinus halepensis L. against aspirin-induced damage in cells in vitro. MATERIAL AND METHODS:The cytoprotection of the oil against toxicity of aspirin on the small intestine epithelial cells IEC-6 was tested. RESULTS:The obtained results have shown that 35 different compounds were identified. Aspirin induced a decrease in cell viability, and exhibited significant damage to their morphology and an increase in superoxide dismutase (SOD) and catalase (CAT) activities. However, the co-treatment of aspirin with the essential oil of Pinus induced a significant increase in cell viability and a decrease in SOD and CAT activities. CONCLUSION:Overall, these finding suggest that the essential oil of Pinus halepensis L. has potent cytoprotective effect against aspirin-induced toxicity in IEC-6 cells.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Bouzenna H,Hfaiedh N,Bouaziz M,Giroux-Metges MA,Elfeki A,Talarmin Hdoi
10.1080/13813455.2017.1347689subject
Has Abstractpub_date
2017-12-01 00:00:00pages
364-370issue
5eissn
1381-3455issn
1744-4160journal_volume
123pub_type
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