Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.

Abstract:

CONTEXT:Vanillin is known to possess important antioxidant activity. OBJECTIVE:The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice. MATERIAL AND METHODS:Mice were exposed during 15 days either to potassium bromate (KBrO3), KBrO3+ vanillin or to only vanillin. RESULTS:Our results revealed a significant modification in the fatty acid composition of the KBrO3-treated mice. In addition, KBrO3 induced a significant reduction in enzymatic activities and gene expressions, Na+ -K+  and Mg2+-ATPases, acetylcholinesterase and butylcholinesterase activities. The gene expression of tumor necrosis factor-α, interleukin-1β, interleukin-6 and COX2, significantly increased in the cerebrum of KBrO3-treated group. Histopathological observations were consistent with these effects. Co-treatment with vanillin significantly attenuated KBrO3-induced oxidative stress and inflammation. CONCLUSION:This work suggests that vanillin mitigates KBrO3-induced depression, and that this neuroprotective effect proceeds through anti-oxidant and anti-inflammatory activities.

journal_name

Arch Physiol Biochem

authors

Ben Saad H,Kharrat N,Driss D,Gargouri M,Marrakchi R,Jammoussi K,Magné C,Boudawara T,Ellouz Chaabouni S,Zeghal KM,Hakim A,Ben Amara I

doi

10.1080/13813455.2017.1283527

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

165-174

issue

3

eissn

1381-3455

issn

1744-4160

journal_volume

123

pub_type

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