A comprehensive systematic review of the effectiveness of Akkermansia muciniphila, a member of the gut microbiome, for the management of obesity and associated metabolic disorders.

Abstract:

AIMS AND BACKGROUND:Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, Akkermansia muciniphila has been proposed as a promising microbe to manage obesity. In the present systematic review, we evaluated evidence on the effectiveness and mechanisms of action of Akkermansia muciniphila supplementation in the management of obesity. METHODS:Electronic databases of MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar were searched thought March 2020 to identify relevant published articles, and eligible articles were systematically reviewed. RESULTS AND CONCLUSIONS:Fifteen studies were included in the present study. Findings from the present review, which included human and animal (rodent) models support the effectiveness of Akkermansia supplementation as a novel therapeutic approach for the management of obesity and metabolic complications associated with obesity. However, future clinical trials are warranted to verify these outcomes.

journal_name

Arch Physiol Biochem

authors

Roshanravan N,Bastani S,Tutunchi H,Kafil B,Nikpayam O,Mesri Alamdari N,Hadi A,Sotoudeh S,Ghaffari S,Ostadrahimi A

doi

10.1080/13813455.2021.1871760

subject

Has Abstract

pub_date

2021-01-15 00:00:00

pages

1-11

eissn

1381-3455

issn

1744-4160

pub_type

杂志文章
  • Determination of the chemical mechanism of neurotransmitter receptor-mediated reactions by rapid chemical kinetic methods.

    abstract::When neurotransmitters bind to their specific receptors in the membrane of nerve and muscle cells they induce conformational transitions leading to the formation of open receptor-channels and desensitized receptor forms. A knowledge of the rate and equilibrium constants associated with these transitions is required to...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章,评审

    doi:10.1076/apab.104.6.752.12911

    authors: Hess GP

    更新日期:1996-10-01 00:00:00

  • Effects of vanillin on potassium bromate-induced neurotoxicity in adult mice: impact on behavior, oxidative stress, genes expression, inflammation and fatty acid composition.

    abstract:CONTEXT:Vanillin is known to possess important antioxidant activity. OBJECTIVE:The current study was conducted to establish the therapeutic efficiency of vanillin against potassium bromate (KBrO3)-induced depression-like behavior and oxidative stress in mice. MATERIAL AND METHODS:Mice were exposed during 15 days eith...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1283527

    authors: Ben Saad H,Kharrat N,Driss D,Gargouri M,Marrakchi R,Jammoussi K,Magné C,Boudawara T,Ellouz Chaabouni S,Zeghal KM,Hakim A,Ben Amara I

    更新日期:2017-07-01 00:00:00

  • Screening newborns for candidate biomarkers of type 1 diabetes.

    abstract::Combining samples from a national neonatal screening programme with the information from a national health registry allow for unique opportunities in analysing newborn blood for protein changes that could predict eventual disease development. A nested case-control cohort (n = 54 cases, 108 controls) was analysed by pr...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.501801

    authors: McGuire JN,Eising S,Wägner AM,Pociot F

    更新日期:2010-10-01 00:00:00

  • Secretory activity and trophic effects of epidermal growth factor in the rat pancreas.

    abstract::This study was to investigate whether epidermal growth factor (EGF) may induce any long-term effect on pancreatic exocrine function in vivo as well to evaluate the chronic effects of EGF on pancreatic growth in rats. Rats were treated with EGF (10 micrograms/kg) for 5 or 7 days. EGF infused intravenously (2 micrograms...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.104.3.293.12909

    authors: Lajas AI,Pozo MJ,Salido GM,Singh J,Pariente JA

    更新日期:1996-01-01 00:00:00

  • Nandrolone modulates the non-opioid and opioid analgesia and tolerance/dependence: role of sexual dimorphism.

    abstract::The aim of this investigation was to study the effect of the doping steroid nandrolone on metamizol and morphine-induced analgesia and tolerance/dependence in rats. Nandrolone per se did not change the basal nociceptive thresholds in both sexes. It diminished the analgesic effect of metamizol in females, revealed by t...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331342283

    authors: Philipova T,Ivanova T,Pavlova E,Kasakov L,Vlaskovska M

    更新日期:2003-12-01 00:00:00

  • Metformin protects red blood cells against rotenone induced oxidative stress and cytotoxicity.

    abstract::Context: The anti-diabetic medicine metformin has been reported as an anti-ageing drug candidate as it mimics the benefits of caloric restriction and reduces ageing-related oxidative stress in various experimental organisms. Objective: We investigated the possible anti-oxidative role of metformin against rotenone-indu...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1620288

    authors: Tripathi SS,Singh AK,Akhtar F,Chaudhary A,Rizvi SI

    更新日期:2019-06-01 00:00:00

  • The effect of nutrition and exercise training on irisin and semaphorin-3E levels in obese patients.

    abstract::We aimed to firstly examine the effects of nutrition and exercise training on irisin, Sema-3E, biochemical and inflammatory parameters in obese patients. This study was conducted using 37 individuals were divided into three groups according to body mass index (BMI) as non-obese, 1nd degree and 2nd degree obese individ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1779310

    authors: Sezgin G,Kar F,Uslu S

    更新日期:2020-06-22 00:00:00

  • Synthetic phosphoinositolglycans regulate lipid metabolism between rat adipocytes via release of GPI-protein-harbouring adiposomes.

    abstract::A novel molecular mechanism for the regulation of lipid metabolism by palmitate, H2O2 and the anti-diabetic sulfonylurea drug, glimepiride, in rat adipocytes was recently elucidated. It encompasses the translocation of the glycosylphosphatidylinositol-anchored (GPI-) and (c)AMP degrading enzymes Gce1 and CD73 from det...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2010.485205

    authors: Müller G,Schulz A,Dearey EA,Wetekam EM,Wied S,Frick W

    更新日期:2010-07-01 00:00:00

  • Fibrotic and apoptotic markers alteration in ovariectomised rats: addition of swimming training preserves lung architecture.

    abstract:CONTEXT:The important role of exercise in pulmonary function during menopause is not well known. Oestrogen deficiency in ageing female mice is accompanied by increase in apoptotic markers such as caspase3 in the lung. OBJECTIVE:The present study was designed to investigate whether swimming training will ameliorate fib...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1396347

    authors: Daghigh F,Alihemmati A,Karimi P,Habibi P,Ahmadiasl N

    更新日期:2018-10-01 00:00:00

  • A novel biomarker explaining the role of oxidative stress in exercise and l-tyrosine supplementation: thiol/disulphide homeostasis.

    abstract::The present study aimed to evaluate the relationship between exercise and both l-tyrosine and oxidative stress using thiol/disulphide homeostasis via a novel biomarker in rats. Following the completion of the exercise and l-tyrosine protocol, serum total thiol, native thiol, and disulphide concentrations were determin...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2017.1388410

    authors: Kayacan Y,Yazar H,Kisa EC,Ghojebeigloo BE

    更新日期:2018-07-01 00:00:00

  • Garlic (Allium sativum) improves anxiety- and depressive-related behaviors and brain oxidative stress in diabetic rats.

    abstract::This study investigated the effects of garlic on anxiety- and depression-related behaviors and brain oxidative markers in streptozotocin (STZ)-induced diabetes in rats. Fifty-six male Wistar rats were randomly divided into seven experimental groups (n = 8/group): control, diabetic + saline, diabetic + garlic, diabetic...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1494746

    authors: Rahmani G,Farajdokht F,Mohaddes G,Babri S,Ebrahimi V,Ebrahimi H

    更新日期:2020-05-01 00:00:00

  • High-intensity interval training (HIIT) effectively enhances heart function via miR-195 dependent cardiomyopathy reduction in high-fat high-fructose diet-induced diabetic rats.

    abstract::Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.Met...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1511599

    authors: Khakdan S,Delfan M,Heydarpour Meymeh M,Kazerouni F,Ghaedi H,Shanaki M,Kalaki-Jouybari F,Gorgani-Firuzjaee S,Rahimipour A

    更新日期:2020-07-01 00:00:00

  • Effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters and serum oxidative stress markers in fructose-induced diabetic Wistar rats.

    abstract::Context: Deleterious effects of diabetes on seminal quality, serum metals and antioxidants have been confirmed.Objective: This study evaluated the effect of combined calcium, magnesium, vitamin C and E supplementation on seminal parameters, serum total antioxidant capacity (TAC), nitric oxide (NO), malonyldialdehyde (...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1716017

    authors: Bassey IE,Ikpi DE,Isong IKP,Akpan UO,Onyeukwu CC,Nwankwo NP,Udofia IG

    更新日期:2020-01-25 00:00:00

  • Body position and the neuroendocrine response to insulin-induced hypoglycemia in healthy subjects.

    abstract::Changes in body fluid distribution are known to influence neuroendocrine function. The aim of the present study was to test the hypothesis that changes in plasma volume affect the counterregulatory neuroendocrine response to hypoglycemia. The tests were performed in 12 subjects in two situations: 'head-up' (+60 degree...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331337658

    authors: Radikova Z,Penesova A,Jezova D,Kvetnansky R,Vigas M,Macho L,Koska J

    更新日期:2003-10-01 00:00:00

  • Myo-inositol oxygenese activity in second trimester of pregnancy: altered myoinositol catabolism in gestational diabetes mellitus.

    abstract::Objective: We aimed to determine myo-inositol oxygenase (MIOX) activity in gestational diabetes mellitus (GDM).Material and Methods: The insulin, HbA1c, and MIOX levels of 80 pregnant women were analysed after 75 g OGTT. Group I included patients with no risk factor for GDM, Group II: patients with high risk for GDM, ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1739714

    authors: Kısa B,Sert UY,Celik HK,Candar T,Erol Koç EM,Taşcı Y,Çağlar GS

    更新日期:2020-03-19 00:00:00

  • Circulating levels of leptin, nesfatin-1 and kisspeptin in postmenopausal obese women.

    abstract::The roles of leptin, nesfatin-1 and kisspeptin in the regulation of food intake and/or reproduction are well known; however, the interactions between these hormones remain unclear, especially in humans. The aim of this study was to determine the roles of leptin, nesfatin-1 and kisspeptin in pre- and postmenopausal obe...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2016.1171365

    authors: Çelik F,Belviranli M,Okudan N

    更新日期:2016-10-01 00:00:00

  • Biochanin A attenuates obesity cardiomyopathy in rats by inhibiting oxidative stress and inflammation through the Nrf-2 pathway.

    abstract:OBJECTIVE:In the present study, we evaluated the effect of biochanin A (BCA) on high-fat diet (HFD)-induced obesity cardiomyopathy. METHODS:BCA (10 mg/kg body weight) was administered to HFD-induced obese rats for 30 days, and its effect on anthropometrical, morphological, plasma cardiac, and inflammatory biomarkers, ...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2021.1874017

    authors: A JIR,Uddandrao VVS,G S,G S,P C,S S,P T,P P S,Vadivukkarasi S

    更新日期:2021-01-20 00:00:00

  • Regulation of G0/G1 switch gene 2 (G0S2) expression in human adipose tissue.

    abstract::The G0/G1 switch gene 2 (G0S2) protein attenuated adipose triglyceride lipase (ATGL) activity and decreased lipolysis in rodent and human adipocytes. We hypothesized that G0S2 mRNA expression in human adipose tissue is influenced by depot, adipocyte size, body weight and caloric intake. Adipose tissue samples were obt...

    journal_title:Archives of physiology and biochemistry

    pub_type: 临床试验,杂志文章

    doi:10.3109/13813455.2015.1122066

    authors: Skopp A,May M,Janke J,Kielstein H,Wunder R,Flade-Kuthe R,Kuthe A,Jordan J,Engeli S

    更新日期:2016-01-01 00:00:00

  • Ulva lactuca methanolic extract improves oxidative stress-related male infertility induced in experimental animals.

    abstract::Aim: This study designated to investigate and compare the therapeutic effect of Ulva lactuca methanolic extract against oxidative stress (OS)-infertility induced by naturally occurring prooxidants (gossypol) and selenium- vitamins A, C, and E (selenium-ACE) drug. Methods: Male infertility was induced in rat by intrape...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1645698

    authors: Ghareeb DA,Abd-Elgwad A,El-Guindy N,Yacout G,Zaatout HH

    更新日期:2019-07-31 00:00:00

  • Carotid body dopamine content and release by short-term hypoxia: effect of haloperidol and alpha methyl paratyrosine.

    abstract::Dopamine (DA) is thought to modulate the transduction of the hypoxic stimulus by the glomus cell in the carotid body (CB). The hypothesis tested here is that presynaptic DA D2 receptors (D2's) located on the type 1 cell function as autoreceptors to control DA release and/or synthesis. The aim of the study was to compa...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1076/apab.105.1.3.13145

    authors: Basson H,Bairam A,Cottet-Emard JM,Pequignot JM,Marchal F

    更新日期:1997-02-01 00:00:00

  • Perceptions of Caribbean type 2 diabetes patients on self-monitoring of blood glucose.

    abstract:CONTEXT:The views of type 2 diabetes (T2DM) patients have not been considered in the debate on the role of self-monitoring of blood glucose (SMBG) in the management of T2DM. OBJECTIVE:To assess the views of T2DM patients on SMBG. METHODS:Two previously trained research assistants used a structured pre-tested question...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2011.625950

    authors: Ezenwaka CE,Olukoga A,Onuoha P,Worrell R,Skinner T,Mayers H,Martin E,Phillip C

    更新日期:2012-02-01 00:00:00

  • The interrelationship between inflammatory cytokines and skeletal muscle decay from the viewpoint of circadian rhythms.

    abstract::Circadian rhythms affect a variety of physiological processes. Disruption of circadian rhythms causes many diseases, most of which are associated with inflammation. Disruption of circadian rhythms has a detrimental impact on the function of immune system. It is common to find that circulatory LPS are increased. LPS in...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1782435

    authors: Luo X,Yang X,Yang Y,Li H,Cui H,Cao X

    更新日期:2020-07-01 00:00:00

  • Molecular targets for steroids in airway vascular smooth muscle.

    abstract::The actions of norepinephrine (NE) released from airway sympathetic nerves are partially terminated by the extraneuronal catecholamine uptake. Because various steroid hormones inhibit extraneuronal uptake, it could be responsible for the airway vasoconstriction caused by inhaled glucocorticosteroids (GSs) in vivo. Usi...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813450312331337559

    authors: Horvath G,Wanner A

    更新日期:2003-10-01 00:00:00

  • Association of hyperglycaemia and hyperlipidaemia with cognitive dysfunction in schizophrenia spectrum disorder.

    abstract::The objective of the study was to investigate the association of blood glucose and lipid profile parameters with cognitive impairment in schizophrenia. A total of 200 schizophrenia patients and 169 controls were enrolled in the study. Blood glucose and lipid profile were estimated in all the subjects. Cognition was as...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1839500

    authors: Nandeesha H,Keshri N,Rajappa M,Menon V

    更新日期:2020-11-03 00:00:00

  • Biochanin A, a soy isoflavone, diminishes insulin resistance by modulating insulin-signalling pathway in high-fat diet-induced diabetic mice.

    abstract:AIM:The objective of this study was to evaluate the probable mechanism of action of Biochanin A (BCA) on high-fat diet-induced insulin resistance mice. METHODS:Twenty-four male C57/BL/6J mice were divided into two and fed either control diet or a high fat-high diet (HFD). After 6 weeks, mice were grouped into: Control...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1820525

    authors: Arjunan S,Thangaiyan R,Balaraman D

    更新日期:2020-09-29 00:00:00

  • Glucokinase activation as antidiabetic therapy: effect of nutraceuticals and phytochemicals on glucokinase gene expression and enzymatic activity.

    abstract::Diabetes represents an important public health problem. Recently, new molecular targets have been identified and exploited to treat this disease. Due to its pivotal role in glucose homeostasis, glucokinase (GCK) is a promising target for the development of novel antidiabetic drugs; however, pharmacological agents that...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2019.1627458

    authors: Guzmán TJ,Gurrola-Díaz CM

    更新日期:2019-06-18 00:00:00

  • Effect of carnosine on erythrocyte deformability in diabetic rats.

    abstract::It is known that oxidative stress plays an important role in the chronic complications of diabetes. Lipid peroxidation is one of the consequences of oxidative stress. Erythrocyte deformability abilities are reduced as a result of lipid peroxidation. Conversely, a decrease nitric oxide (NO) production seems to be respo...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.3109/13813455.2012.714790

    authors: Yapislar H,Aydogan S

    更新日期:2012-12-01 00:00:00

  • Spirulina effect on modulation of toxins provided by food, impact on hepatic and renal functions.

    abstract::Spirulina platensis, is an alga rich in phycocyanin (potent antioxidant), is effective in regulating the balance of oxidative stress. The objective of this study is to observe the impact of ingestion of a highly oxidised vegetable oil, by rats of Wistar strain. Finally, we observe the effect of Spirulina used as an an...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1444059

    authors: Ould Amara-Leffad L,Ramdane H,Nekhoul K,Ouznadji A,Koceir EA

    更新日期:2019-05-01 00:00:00

  • Folic acid increases levels of GHS in brain of rats with oxidative stress induced with 3-nitropropionic acid.

    abstract::Aim: This study tested the hypothesis that folic acid (FA) modulates biogenic amines and protects the brain against oxidative stress induced by 3-nitropropionic acid (3NPA).Methods: Male Wistar rats received (groups of six) for 5 d: FA (50 mg/kg); 3NPA (10 mg/kg); or FA +3NPA. At last day, rats were sacrificed, and th...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2018.1484771

    authors: Calderón Guzmán D,Osnaya Brizuela N,Ortiz Herrera M,Juárez Olguín H,Valenzuela Peraza A,Hernández García E,Barragán Mejía G

    更新日期:2020-02-01 00:00:00

  • Suppression of knee joint osteoarthritis induced secondary to type 2 diabetes mellitus in rats by resveratrol: role of glycated haemoglobin and hyperlipidaemia and biomarkers of inflammation and oxidative stress.

    abstract::Background: We investigated whether the anti-inflammatory and antioxidant agent, resveratrol can inhibit type 2 diabetes mellitus (T2DM)-induced osteoarthritis (OA) in rats and whether it is associated with the suppression of glycaemia, dyslipidemia and inflammatory and oxidative stress biomarkers.Materials and method...

    journal_title:Archives of physiology and biochemistry

    pub_type: 杂志文章

    doi:10.1080/13813455.2020.1771378

    authors: Ebrahim HA,Alzamil NM,Al-Ani B,Haidara MA,Kamar SS,Dawood AF

    更新日期:2020-06-04 00:00:00