Abstract:
AIMS AND BACKGROUND:Obesity is recognised as a significant public health burden worldwide. Recently the cross-talk between gut microbiota and obesity has attracted much attention. To that end, Akkermansia muciniphila has been proposed as a promising microbe to manage obesity. In the present systematic review, we evaluated evidence on the effectiveness and mechanisms of action of Akkermansia muciniphila supplementation in the management of obesity. METHODS:Electronic databases of MEDLINE, PubMed, Scopus, Web of Science, and Google Scholar were searched thought March 2020 to identify relevant published articles, and eligible articles were systematically reviewed. RESULTS AND CONCLUSIONS:Fifteen studies were included in the present study. Findings from the present review, which included human and animal (rodent) models support the effectiveness of Akkermansia supplementation as a novel therapeutic approach for the management of obesity and metabolic complications associated with obesity. However, future clinical trials are warranted to verify these outcomes.
journal_name
Arch Physiol Biochemjournal_title
Archives of physiology and biochemistryauthors
Roshanravan N,Bastani S,Tutunchi H,Kafil B,Nikpayam O,Mesri Alamdari N,Hadi A,Sotoudeh S,Ghaffari S,Ostadrahimi Adoi
10.1080/13813455.2021.1871760subject
Has Abstractpub_date
2021-01-15 00:00:00pages
1-11eissn
1381-3455issn
1744-4160pub_type
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