Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model.

abstract：:Fifteen human glioma cell lines were examined for their sensitivity to 1,3-bis(chloroethyl)-nitrosourea (BCNU, carmustine) and cis-dichlorodiamminoplatinum (cisplatin), the induction of DNA interstrand cross-linking (DNA-ISC) induced by the two agents and cellular O6-alkylguanine alkyltransferase (ATase) activity. Cel...

journal_title：British journal of cancer

authors： Beith J,Hartley J,Darling J,Souhami R

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:To evaluate the anticancer activity of erlotinib in patients with previously treated, advanced non-small cell lung cancer (NSCLC) whose dose is increased to that associated with a maximal level of tolerable skin toxicity (i.e., target rash (TR)); to characterise the pharmacokinetics (PK) and pharmacodynamics...

journal_title：British journal of cancer

authors： Mita AC,Papadopoulos K,de Jonge MJ,Schwartz G,Verweij J,Mita MM,Ricart A,Chu QS,Tolcher AW,Wood L,McCarthy S,Hamilton M,Iwata K,Wacker B,Witt K,Rowinsky EK

更新日期：2011-09-27 00:00:00

abstract：:Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.0...

journal_title：British journal of cancer

authors： Jones S,Lambert S,Williams GT,Best JM,Sampson JR,Cheadle JP

更新日期：2004-04-19 00:00:00

abstract：:We assessed the association of postmenopausal serum levels of oestrogens and sex hormone-binding globulin (SHBG) with endometrial cancer risk in a case-control study nested within the NYU Women's Health Study cohort. Among 7054 women postmenopausal at enrolment, 57 cases of endometrial cancer were diagnosed a median o...

journal_title：British journal of cancer

authors： Zeleniuch-Jacquotte A,Akhmedkhanov A,Kato I,Koenig KL,Shore RE,Kim MY,Levitz M,Mittal KR,Raju U,Banerjee S,Toniolo P

更新日期：2001-04-06 00:00:00

abstract：:We compared the long-term impact of 1- and 2-year screening mammography intervals using prognostic, screening, and outcome information for women aged 50-74 years obtained from the Screening Mammography Program of British Columbia in two time periods, prior to 1997 (policy of annual mammography) and after 1997 (biennia...

journal_title：British journal of cancer

authors： Wai ES,D'yachkova Y,Olivotto IA,Tyldesley S,Phillips N,Warren LJ,Coldman AJ

更新日期：2005-03-14 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：:Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...

journal_title：British journal of cancer

authors： Vasey PA,McMahon L,Paul J,Reed N,Kaye SB

更新日期：2003-11-17 00:00:00

abstract：:This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(-2) DL), combined with cisplatin (standard dose 75 mg m(-2)). In 16 patients with advanced malignancies treated, one patien...

journal_title：British journal of cancer

authors： du Bois A,Jung B,Loehr A,Schaller-Kranz T,Cohen M,Frickhofen N

更新日期：2006-01-16 00:00:00

abstract：:We have shown that doxorubicin entrapped in cardiolipin liposomes retain antitumour efficacy in mice but had diminished cardiac uptake and cardiotoxicity. Such liposomes are preferentially taken up by spleen. In a previous study we showed that a single dose of liposomal doxorubicin is not more toxic than free doxorubi...

journal_title：British journal of cancer

authors： Rahman A,Joher A,Neefe JR

更新日期：1986-09-01 00:00:00

abstract：:Data from the Oxford Survey have shown that childhood cancers are causes of in utero deaths which affect leukaemias more than solid tumours and difficult deliveries more than easy ones. As a result of these biases singletons give the impression of being more leukaemia-sensitive than twins. This is a false impression w...

journal_title：British journal of cancer

authors： Stewart AM

更新日期：1973-06-01 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) mutations are strong determinants of tumour response to EGFR tyrosine kinase inhibitors in non-small-cell lung cancer (NSCLC). Pleural effusion is a common complication of lung cancer. In this study, we assessed the feasibility of detection of EGFR mutations in samples of pleura...

journal_title：British journal of cancer

authors： Kimura H,Fujiwara Y,Sone T,Kunitoh H,Tamura T,Kasahara K,Nishio K

更新日期：2006-11-20 00:00:00

abstract：:To find out whether ultrasound-guided fine-needle aspiration (FNA) and ultrasound and stereotactic-guided large core needle biopsy (LCNB) are reliable alternatives to needle-localised open breast biopsy (NLBB) in daily practice, we performed a retrospective study and evaluated the validity of these methods. In all, 71...

journal_title：British journal of cancer

authors： Pijnappel RM,van den Donk M,Holland R,Mali WP,Peterse JL,Hendriks JH,Peeters PH

更新日期：2004-02-09 00:00:00

abstract：:In a meta-analysis of testicular cancer in twins, twins had a 30% increased risk (estimate 1.31, 95% CI 1.1-1.6), providing indirect support for the hypothesis that in utero hormone variations influence risk of testicular cancer. The summary-estimate for dizygotic twins was 1.3 (1.0-1.7) and for monozygotic or same se...

journal_title：British journal of cancer

authors： Neale RE,Carrière P,Murphy MF,Baade PD

更新日期：2008-01-15 00:00:00

abstract：:The ESPAC-1, ESPAC-1 plus, and early ESPAC-3(v1) results (458 randomized patients; 364 deaths) were used to estimate the effectiveness of adjuvant 5FU/FA vs resection alone for pancreatic cancer using meta-analysis. The pooled hazard ratio of 0.70 (95% CI=0.55-0.88) P=0.003, and the median survival of 23.2 (95% CI=20....

journal_title：British journal of cancer

authors： Neoptolemos JP,Stocken DD,Tudur Smith C,Bassi C,Ghaneh P,Owen E,Moore M,Padbury R,Doi R,Smith D,Büchler MW

更新日期：2009-01-27 00:00:00

abstract：BACKGROUND:Favourable outcomes of breast cancer screening trials in the 1970s and 1980s resulted in the launch of population-based service screening programmes in many Western countries. We investigated whether improvements in mammography and treatment modalities have had an influence on the effectiveness of breast can...

journal_title：British journal of cancer

authors： van Schoor G,Moss SM,Otten JD,Donders R,Paap E,den Heeten GJ,Holland R,Broeders MJ,Verbeek AL

更新日期：2011-03-15 00:00:00

abstract：:BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...

journal_title：British journal of cancer

authors： Chieco-Bianchi L,Collavo D,Biasi G,Colombatti A

更新日期：1973-09-01 00:00:00

abstract：:The aim of the study was to investigate whether 99Tc(m)-MIBI (Cardiolite), recently shown to be a substrate for P-glycoprotein, has the potential to be used as a marker for mdr1 gene expression and whether cyclosporin A (CyA) can modify its accumulation in vivo. Leukaemic cells from ten patients with acute myelocytic ...

journal_title：British journal of cancer

authors： Gruber A,Areström I,Xu D,Liliemark J,Larsson SA,Jacobsson H

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Dysregulation of microRNAs (miRNAs) has been found in human epithelial ovarian cancer (EOC). However, the role and mechanism of action of miR-23a in EOC remain unclear. METHODS:The roles of miR-23a, IKKα, and ST7L in EOC were determined by MTT, colony formation, wounding healing, transwell, flow cytometry, ...

journal_title：British journal of cancer

authors： Yang Z,Wang XL,Bai R,Liu WY,Li X,Liu M,Tang H

更新日期：2016-09-06 00:00:00

abstract：:Disseminating disease is a predictive and prognostic indicator of poor outcome in children with neuroblastoma. Its accurate and sensitive assessment can facilitate optimal treatment decisions. The International Neuroblastoma Risk Group (INRG) Task Force has defined standardised methods for the determination of minimal...

journal_title：British journal of cancer

authors： Beiske K,Burchill SA,Cheung IY,Hiyama E,Seeger RC,Cohn SL,Pearson AD,Matthay KK,International neuroblastoma Risk Group Task Force.

更新日期：2009-05-19 00:00:00

abstract：BACKGROUND:The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be useful as PC biomarkers. METHODS:Initially, we carried out miR microarray and real-time PCR using RWPE-1, PC-3, DU-145 and LNCaP cells. To ...

journal_title：British journal of cancer

authors： Ueno K,Hirata H,Shahryari V,Deng G,Tanaka Y,Tabatabai ZL,Hinoda Y,Dahiya R

更新日期：2013-04-30 00:00:00

abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

journal_title：British journal of cancer

authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

更新日期：2020-02-01 00:00:00

abstract：:A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...

journal_title：British journal of cancer

authors： Staab HJ,Anderer FA

更新日期：1978-10-01 00:00:00

abstract：:A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), induced significant RTA...

journal_title：British journal of cancer

authors： Embleton MJ,Charleston A,Robins RA,Pimm MV,Baldwin RW

更新日期：1991-05-01 00:00:00

abstract：:Lymph node pathologic status is the most important prognostic factor in vulvar cancer; however, complete inguinofemoral node dissection is associated with significant morbidity. Lymphoscintigraphy associated with gamma-probe guided surgery reliably detects sentinel nodes in melanoma and breast cancer patients. This st...

journal_title：British journal of cancer

authors： De Cicco C,Sideri M,Bartolomei M,Grana C,Cremonesi M,Fiorenza M,Maggioni A,Bocciolone L,Mangioni C,Colombo N,Paganelli G

更新日期：2000-01-01 00:00:00

abstract：:In a variety of adult and childhood leukaemia cell samples collected at different states of the disease, we analysed in a series of sequentially performed slot-blot or Northern-blot hybridisation experiments the expression of genes possibly involved in multiple drug resistance (MDR) (mdr1/P-glycoprotein, DNA topoisome...

journal_title：British journal of cancer

authors： Gekeler V,Frese G,Noller A,Handgretinger R,Wilisch A,Schmidt H,Muller CP,Dopfer R,Klingebiel T,Diddens H

更新日期：1992-09-01 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：:One hundred resected cases of squamous cell carcinomas of the oesophagus were reviewed and a series of histological criteria related to the survival time. Two histological features were important in the assessment of survival. Good prognostic factors were a marked lymphocytic response to the tumour and a lack of intra...

journal_title：British journal of cancer

authors： Edwards JM,Hillier VF,Lawson RA,Moussalli H,Hasleton PS

更新日期：1989-03-01 00:00:00

abstract：:Adriamycin and cyclophosphamide are active agents in human and experimental tumours. Using the L1210 murine leukaemia, their effectiveness alone and in combination was studied. The combination is highly synergistic in this tumour, resulting in a greater than 50% survival rate when the agents used alone at optimal dose...

journal_title：British journal of cancer

authors： Tobias JS,Parker LM,Tattersall MH,Frei E 3rd

更新日期：1975-08-01 00:00:00

abstract：:Thirty patients with previously treated metastatic breast cancer were entered in a phase II study with oral lonidamine. Twenty-eight patients are evaluable for toxicity and 25 for response. A partial remission was obtained in four patients (16%) and disease stability in 11 (44%): 10 patients progressed (40%). Toxicity...

journal_title：British journal of cancer

authors： Pronzato P,Amoroso D,Bertelli G,Conte PF,Cusimano MP,Ciottoli GB,Gulisano M,Lionetto R,Rosso R

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Although mortality rates are elevated in psychiatric patients relative to their healthy counterparts, little is known about the impact of mental health on survival in people with cancer. METHODS AND RESULTS:Among 16 498 Swedish men with cancer, survival was worse in those with a history of psychiatric hospi...

journal_title：British journal of cancer

authors： Batty GD,Whitley E,Gale CR,Osborn D,Tynelius P,Rasmussen F

更新日期：2012-05-22 00:00:00