microRNA-183 is an oncogene targeting Dkk-3 and SMAD4 in prostate cancer.

abstract：:Histochemical studies on the cell surface and intercellular matrix of normal cervical epithelium, and squamous cell carcinomata have shown the mucosubstances present may be symbolized by the descriptive formula:C(G) mucosubstance; B 3.5; A 2.5 (0.6m MgCl(2)); T; S.This indicates that sulphate groups are absent and tha...

journal_title：British journal of cancer

authors： Bradbury S,Wiernik G,Williams EA,Cowdell RH

更新日期：1970-12-01 00:00:00

abstract：BACKGROUND:Tumours consist of heterogeneous cancer cells and are likely to contain drug-tolerant cell subpopulations, causing early relapse. However, treatment strategies to eliminate these cells have not been established. METHODS:We established gastric cancer patient-derived cells (PDCs) to examine the contribution o...

journal_title：British journal of cancer

authors： Mashima T,Iwasaki R,Kawata N,Kawakami R,Kumagai K,Migita T,Sano T,Yamaguchi K,Seimiya H

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Subgroup analyses of clinical studies suggest that bevacizumab plus XELOX is effective and tolerable in elderly patients with metastatic colorectal cancer (mCRC). The prospective BECOX study examined the efficacy and safety of bevacizumab plus XELOX, followed by bevacizumab plus capecitabine in elderly patie...

journal_title：British journal of cancer

authors： Feliu J,Salud A,Safont MJ,García-Girón C,Aparicio J,Vera R,Serra O,Casado E,Jorge M,Escudero P,Bosch C,Bohn U,Pérez-Carrión R,Carmona A,Martínez-Marín V,Maurel J

更新日期：2014-07-15 00:00:00

abstract：:Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...

journal_title：British journal of cancer

authors： Dworkin MJ,Carnochan P,Allen-Mersh TG

更新日期：1997-01-01 00:00:00

abstract：:Trastuzumab has significantly improved the overall survival of patients with HER2+ metastatic breast cancer (MBC). However, outcomes can vary, with patients progressing within 1 year of treatment or exceptional cases of complete response to trastuzumab for ≥10 years. Identification of the underlying genomic aberration...

journal_title：British journal of cancer

authors： Walsh N,Andrieu C,O'Donovan P,Quinn C,Maguire A,Furney SJ,Gullo G,Crown J

更新日期：2020-10-01 00:00:00

abstract：:The identification of peptide vaccine candidates to date has been focused on human leukocyte antigen (HLA)-A2 and -A24 alleles. In this study, we attempted to identify cytotoxic T lymphocyte (CTL)-directed Lck-derived peptides applicable to HLA-A11(+), -A31(+), or -A33(+) cancer patients, because these HLA-A alleles s...

journal_title：British journal of cancer

authors： Naito M,Komohara Y,Ishihara Y,Noguchi M,Yamashita Y,Shirakusa T,Yamada A,Itoh K,Harada M

更新日期：2007-12-17 00:00:00

abstract：:We report observations on the spread by metastasis and infiltration of a transplantable tumour in rats treated by 60Co gamma-irradiation of the primary, irradiation plus parenteral cyclophosphamide, or parenteral cyclophosphamide alone. The proportion of animals with overt disseminated disease and the extent of spread...

journal_title：British journal of cancer

authors： Moore JV,Dixon B

更新日期：1977-08-01 00:00:00

abstract：:The biguanide drug metformin profoundly affects cell metabolism, causing an impairment of the cell energy balance and triggering a plethora of pleiotropic effects that vary depending on the cellular or environmental context. Interestingly, a decade ago, it was observed that metformin-treated diabetic patients have a s...

journal_title：British journal of cancer

authors： Sacco F,Calderone A,Castagnoli L,Cesareni G

更新日期：2016-12-06 00:00:00

abstract：:The level of expression of the multidrug resistance-associated protein (MRP1) in a panel of human ovarian carcinoma cell lines and their variants with acquired cisplatin resistance was determined using Western blotting. No overexpression of MRP1 was detected in any of the cell lines. In addition, we have transfected t...

journal_title：British journal of cancer

authors： Sharp SY,Smith V,Hobbs S,Kelland LR

更新日期：1998-07-01 00:00:00

abstract：:The development of an altered stromal microenvironment is a common feature of many tumours including squamous cell carcinoma (SCC), and there is increasing evidence that these changes in the stroma, which include increased expression of proteases and cytokines, may actually promote tumour progression. A common finding...

journal_title：British journal of cancer

authors： Lewis MP,Lygoe KA,Nystrom ML,Anderson WP,Speight PM,Marshall JF,Thomas GJ

更新日期：2004-02-23 00:00:00

abstract：:In the BUPA Study, a prospective study of 22,000 men attending a screening centre in London, serum samples were collected and stored. The concentration of beta-carotene was measured in the stored serum samples from 271 men who were subsequently notified as having cancer and from 533 unaffected controls, matched for ag...

journal_title：British journal of cancer

authors： Wald NJ,Thompson SG,Densem JW,Boreham J,Bailey A

更新日期：1988-04-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to detect copy number changes of DNA sequences in the Ewing family of tumours (ET). We analysed 20 samples from 17 patients. Fifteen tumours (75%) showed copy number changes. Gains of DNA sequences were much more frequent than losses, the majority of the gains affecting...

journal_title：British journal of cancer

authors： Armengol G,Tarkkanen M,Virolainen M,Forus A,Valle J,Böhling T,Asko-Seljavaara S,Blomqvist C,Elomaa I,Karaharju E,Kivioja AH,Siimes MA,Tukiainen E,Caballín MR,Myklebost O,Knuutila S

更新日期：1997-01-01 00:00:00

abstract：:Treatment of ex-breeder male NMRI mice with lipid mobilising factor isolated from the urine of cachectic cancer patients, caused a significant increase in glucose oxidation to CO2 compared with control mice receiving phosphate buffered saline. Glucose utilisation by various tissues was determined by the 2-deoxyglucose...

journal_title：British journal of cancer

authors： Russell ST,Tisdale MJ

更新日期：2002-08-27 00:00:00

abstract：:Peutz-Jeghers syndrome (PJS) and juvenile polyposis (JPS) are both characterized by the presence of hamartomatous polyps and increased risk of malignancy in the gastrointestinal tract. Mutations of the LKB1 and SMAD4 genes have been shown recently to cause a number of PJS and JPS cases respectively, but there remains ...

journal_title：British journal of cancer

authors： Woodford-Richens KL,Halford S,Rowan A,Bevan S,Aaltonen LA,Wasan H,Bicknell D,Bodmer WF,Houlston RS,Tomlinson IP

更新日期：2001-05-18 00:00:00

abstract：:The objective of the study was to evaluate the effect of neoadjuvant chemotherapy on the survival of patients with oropharyngeal cancer. Patients with a squamous cell carcinoma of the oropharynx for whom curative radiotherapy or surgery was considered feasible were entered in a multicentric randomized trial comparing ...

journal_title：British journal of cancer

authors： Domenge C,Hill C,Lefebvre JL,De Raucourt D,Rhein B,Wibault P,Marandas P,Coche-Dequeant B,Stromboni-Luboinski M,Sancho-Garnier H,Luboinski B,French Groupe d'Etude des Tumeurs de la Tête et du Cou (GETTEC).

更新日期：2000-12-01 00:00:00

abstract：:The widely held belief that 2-naphthylamine is not carcinogenic for the rat has been re-examined. Twenty female Wistar rats were dosed by gastric intubation weekly for 57 weeks with 2-naphthylamine, 300 mg/kg body wt, in arachis oil and 20 controls were given arachis oil alone. Animals which became moribund were kille...

journal_title：British journal of cancer

authors： Hicks RM,Wright R,Wakefield JS

更新日期：1982-10-01 00:00:00

abstract：:Many theories mention hypersensitive, promiscuous, outlaw or bypass signalling pathways to explain the acquisition of hormone independence in prostate cancer. Hormonal escape of prostate tumours is marked by many biological changes, including mucinous and neuroendocrine differentiation. Since expression of several muc...

journal_title：British journal of cancer

authors： Legrier ME,de Pinieux G,Boyé K,Arvelo F,Judde JG,Fontaine JJ,Bara J,Poupon MF

更新日期：2004-02-09 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:The effect of 10(-6) M tamoxifen on MCF-7 cells adapted to growth in 0.5% foetal calf serum has been studied. The growth inhibitory effect of this tamoxifen concentration was abolished by simultaneous addition of 10(-8) M oestradiol, indicating that tamoxifen may exert its effect via binding to the oestrogen receptor....

journal_title：British journal of cancer

authors： Lykkesfeldt AE,Larsen JK,Christensen IJ,Briand P

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Efficacy and safety are the two considerations when characterising the effects of a new therapy. We sought to apply an innovative method of assessing the benefit-risk balance using data from a completed randomised controlled trial that compared erlotinib vs placebo added to gemcitabine in patients with advan...

journal_title：British journal of cancer

authors： Péron J,Roy P,Ding K,Parulekar WR,Roche L,Buyse M

更新日期：2015-03-17 00:00:00

abstract：BACKGROUND:We performed a retrospective nationwide study to explore age as a prognostic factor in synovial sarcoma patients. METHODS:Data on 613 synovial sarcoma patients were obtained from the Netherlands Cancer Registry. The prognostic relevance of age groups (children, adolescent and young adults (AYAs), adults, an...

journal_title：British journal of cancer

authors： Vlenterie M,Ho VK,Kaal SE,Vlenterie R,Haas R,van der Graaf WT

更新日期：2015-12-01 00:00:00

abstract：:Birth size of a woman has been positively associated with her breast cancer risk, particularly before menopause, but no study has investigated neonatal growth in relation to this risk. We conducted a case-control study nested within a population-based cohort of women, born in Sweden between 1901 and 1961, covering all...

journal_title：British journal of cancer

authors： Lagiou P,Hsieh CC,Trichopoulos D,Adami HO,Hall P,Chie L,Ekbom A

更新日期：2008-11-04 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：:To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libr...

journal_title：British journal of cancer

authors： Shi YY,Wang HC,Yin YH,Sun WS,Li Y,Zhang CQ,Wang Y,Wang S,Chen WF

更新日期：2005-03-14 00:00:00

abstract：:Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease, and its incidence is increasing as the populations in Western countries age. Despite major advances in understanding the genetic landscape of AML and its impact on the biology of the disease, standard therapy has not changed significa...

journal_title：British journal of cancer

authors： Cassier PA,Castets M,Belhabri A,Vey N

更新日期：2017-10-10 00:00:00

abstract：:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...

journal_title：British journal of cancer

authors： Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski T

更新日期：2002-06-17 00:00:00

abstract：:In vivo DNA damage and repair was induced by nicotinamide (NAM) in adenotype 12 virus-induced mouse sarcoma A12B3 and sarcoma F inoculated into CBA mice. DNA damage, NAM and NAD concentrations were measured after in vivo exposure to NAM, in tumours and spleens by alkaline elution and by HPLC analysis. Our results indi...

journal_title：British journal of cancer

authors： Olsson AR,Sheng Y,Pero RW,Chaplin DJ,Horsman MR

更新日期：1996-08-01 00:00:00

abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...

journal_title：British journal of cancer

authors： Piqueras M,Navarro S,Cañete A,Castel V,Noguera R

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and...

journal_title：British journal of cancer

authors： Pruikkonen S,Kallio MJ

更新日期：2017-05-23 00:00:00

abstract：BACKGROUND:Patients whose colorectal cancer is treated after an emergency admission tend to have late-stage cancer and a poor prognosis. We identified risk factors for an emergency admission by linking data from the National Bowel Cancer Audit (NBCA) and the English Hospital Episode Statistics (HES), an administrative ...

journal_title：British journal of cancer

authors： Wallace D,Walker K,Kuryba A,Finan P,Scott N,van der Meulen J

更新日期：2014-07-29 00:00:00