Abstract:
:The development of an altered stromal microenvironment is a common feature of many tumours including squamous cell carcinoma (SCC), and there is increasing evidence that these changes in the stroma, which include increased expression of proteases and cytokines, may actually promote tumour progression. A common finding is that stromal fibroblasts become 'activated' myofibroblasts, expressing smooth muscle actin and secreting cytokines, proteases and matrix proteins. We show that myofibroblasts are commonly found in the stroma of oral SCC and are often concentrated at the invasive margin of the tumour. Using oral SCC cells and primary oral fibroblasts, we demonstrate that tumour cells directly induce a myofibroblastic phenotype, and that this transdifferentiation is dependent on SCC-derived TGF-beta1. In turn, myofibroblasts secrete significantly higher levels of hepatocyte growth factor/scatter factor compared with fibroblast controls, and this cytokine promotes SCC invasion through Matrigel, a mixture of basement membrane proteins. This is the first time that this double paracrine mechanism has been demonstrated between squamous carcinoma cells and fibroblasts, and emphasises that cancer invasion can be promoted indirectly by the release of tumour-induced host factors from stroma.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lewis MP,Lygoe KA,Nystrom ML,Anderson WP,Speight PM,Marshall JF,Thomas GJdoi
10.1038/sj.bjc.6601611subject
Has Abstractpub_date
2004-02-23 00:00:00pages
822-32issue
4eissn
0007-0920issn
1532-1827pii
6601611journal_volume
90pub_type
杂志文章abstract::The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and sele...
journal_title:British journal of cancer
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abstract::Using a highly sensitive chemiluminescent enzyme immunoassay, we have evaluated the measurement of serum prostate-specific antigen (PSA) as a potential diagnostic test for differentiation between women with breast cancer and those with benign breast disease. In a controlled study consisting of 284 women with well-docu...
journal_title:British journal of cancer
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journal_title:British journal of cancer
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journal_title:British journal of cancer
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journal_title:British journal of cancer
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journal_title:British journal of cancer
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doi:10.1038/bjc.1998.89
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abstract::In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1991-07-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
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doi:10.1038/sj.bjc.6604508
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pub_type: 杂志文章
doi:10.1038/bjc.2014.65
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abstract::In a population-based, matched, case-control study from southern Sweden of 571 patients with a first diagnosis of cutaneous malignant melanoma and 913 healthy controls aged 16-80 years, the association between sunbed use and malignant melanoma was evaluated. A total of 250 (44%) cases and 372 (41%) controls reported e...
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pub_type: 杂志文章
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journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1980.64
更新日期:1980-03-01 00:00:00
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doi:10.1038/sj.bjc.6605821
更新日期:2010-08-10 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.29
更新日期:1985-02-01 00:00:00
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journal_title:British journal of cancer
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更新日期:2007-12-03 00:00:00
abstract::Clonal subpopulations of different ploidy values and metastatic capacities, isolated from the RIF-1 mouse sarcoma, have been tested for in vitro X-radiation sensitivity, for in vitro sensitivity to adriamycin and for in vitro and in vivo sensitivity to melphalan and CCNU. Following X-radiation, no consistent differenc...
journal_title:British journal of cancer
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:British journal of cancer
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更新日期:2008-12-02 00:00:00
abstract::Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...
journal_title:British journal of cancer
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pub_type: 杂志文章
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更新日期:2007-03-12 00:00:00
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journal_title:British journal of cancer
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更新日期:2013-06-11 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.241
更新日期:1990-07-01 00:00:00