Abstract：
BACKGROUND:The interaction between human prostate cancer (PCa) cells and bone marrow (BM) endothelium follows a rolling-and-adhesion cascade mediated by E-selectin ligand (ESL): E-selectin. This adhesion is enabled by elevated expression of α-1,3-fucosyltransferases (FTs), enzymes responsible for ESL-mediated bone metastasis in humans. In contrast, the incidence of bone metastasis in mice is rare. METHODS:FT 3, 6 and 7 were overexpressed in mouse PCa cells. The rolling cell number, cell-rolling velocity and transendothelial migration were characterised in vitro. Fucosyltransferases-transduced mouse PCa cells expressing luciferase were inoculated into mice via left ventricle to compare the capability of bone metastasis. Mass spectrometry and immunoprecipitation were utilised for identification of ESLs. RESULTS:Overexpression of FT3, FT6 or FT7 restored ESLs and enabled mouse PCa cells to roll and adhere in E-selectin-functionalised microtubes, similar to trafficking of circulating PCa cells in BM vessels. Following intracardiac inoculation, FT6-transduced cells induced robust bone metastasis in mice. Inhibition of FT6 by a fucose mimetic significantly reduced bone metastasis. Importantly, comparison of FT3, FT6 and FT7 gene expression in existing clinical samples showed significant upregulation of FT6 in PCa-distant metastases. CONCLUSION:FT6 is a key mediator of PCa cells trafficking to the BM. It may serve as a viable drug target in preclinical tests of therapeutics for reduction of PCa bone metastasis.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Li J,Guillebon AD,Hsu JW,Barthel SR,Dimitroff CJ,Lee YF,King MRdoi
10.1038/bjc.2013.690subject
Has Abstractpub_date
2013-12-10 00:00:00pages
3014-22issue
12eissn
0007-0920issn
1532-1827pii
bjc2013690journal_volume
109pub_type
杂志文章abstract：:I have studied the effects on growth of two tumours in mice and on host toxicity, of combining Misonidazole (MISO) or Metronidazole (METRO) with Methotrexate (MTX)-5-fluorouracil (FU) or Adriamycin (ADR). The nitroimidazoles alone had no effect on the growth of either tumour, but MISO (1 mg/g) led to a small increase ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1980.334
更新日期：1980-12-01 00:00:00
abstract：:The survival of 64 consecutive patients with disseminated midgut carcinoid tumours was compared in a retrospective study with that of 25 consecutive patients with sporadic malignant endocrine pancreatic tumours treated according to similar surgical principles. The presence of hepatic metastases implied a worse prognos...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690494
更新日期：1999-06-01 00:00:00
abstract：:We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosom...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.496
更新日期：1998-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.460
更新日期：2018-03-20 00:00:00
abstract：BACKGROUND:Faecal immunochemical tests (FITs) have replaced guaiac-based faecal occult blood test (gFOBTs) in several colorectal cancer (CRC) screening programmes. We aimed to evaluate the benefits of this transition based on the Wallonia-Brussels-organised CRC screening programme. METHODS:A total of 1,569,868 individ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0754-5
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1993.178
更新日期：1993-05-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6605718
更新日期：2010-06-29 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章,随机对照试验
doi：10.1038/bjc.2012.309
更新日期：2012-08-07 00:00:00
abstract：:Allele imbalance on chromosome 11 loci in ovarian cancer is a frequent event, suggesting the presence of tumour-suppressor genes for ovarian carcinogenesis on this chromosome. Ten highly polymorphic (CA) repeat microsatellites were used to determine allele imbalance in 60 primary ovarian tumours, including 47 epitheli...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1995.340
更新日期：1995-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.34
更新日期：1982-02-01 00:00:00
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journal_title：British journal of cancer
pub_type： 已发布勘误
doi：10.1038/s41416-020-0879-6
更新日期：2020-08-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.29
更新日期：1996-01-01 00:00:00
abstract：BACKGROUND:Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. ME...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2015.207
更新日期：2015-07-14 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-01229-1
更新日期：2021-01-26 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603385
更新日期：2006-10-23 00:00:00
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journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/bjc.1993.69
更新日期：1993-02-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6606025
更新日期：2011-01-18 00:00:00
abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.117
更新日期：1997-01-01 00:00:00
abstract：:The malignant epithelial cells of nasopharyngeal carcinoma (NPC) and cells of lines derived form the lymphoid cells which infiltrate this tumour have been investigated cytogenetically. Chromosome spreads of lymphoblastoid cells of lines established from 7 different NPC biopsy specimens were examined after banding stai...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1978.31
更新日期：1978-02-01 00:00:00
abstract：BACKGROUND:This study aims to investigate the association between statin use and all-cancer survival in a prospective cohort of postmenopausal women, using data from the Women's Health Initiative Observational Study (WHI-OS) and Clinical Trial (WHI-CT). METHODS:The WHI study enrolled women aged 50-79 years from 1993 t...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.63
更新日期：1986-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.159
更新日期：1989-05-01 00:00:00
abstract：:The in vitro metabolisms of [14C]7,12-dimethylbenz(a)anthracene (DMBA) by post-mitochondrial supernates and microsomes from intact and regenerating rat livers were compared. Both cell fractions from regenerating livers at 48, 72, and 96 h after partial hepatectomy metabolized less [14C]DMBA than similar fractions from...
journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：1977-06-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2000.1363
更新日期：2000-09-01 00:00:00
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pub_type： 杂志文章
doi：10.1038/s41416-018-0323-3
更新日期：2018-12-01 00:00:00
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pub_type： 临床试验,杂志文章,多中心研究
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journal_title：British journal of cancer
pub_type： 杂志文章
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更新日期：2004-04-05 00:00:00
abstract：BACKGROUND:The clinical utility of machine-learning (ML) algorithms for breast cancer risk prediction and screening practices is unknown. We compared classification of lifetime breast cancer risk based on ML and the BOADICEA model. We explored the differences in risk classification and their clinical impact on screenin...
journal_title：British journal of cancer
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更新日期：2020-09-01 00:00:00
abstract：:The distribution of labelled cells through 5 different mouse tumours was measured after a single injection of [3H]-thymidine [( 3H]-TdR) or [3H]-deoxyuridine [( 3H]-UdR). All the tumours had areas where the percentage of labelled cells (the labelling index, LI) was high and areas where the LI was very low. The total a...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.3
更新日期：1985-01-01 00:00:00
