The significance of electron spin resonance of the ascorbic acid radical in freeze dried human brain tumours and oedematous or normal periphery.

abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

journal_title：British journal of cancer

authors： Olive PL,Banáth JP,Evans HH

更新日期：1993-03-01 00:00:00

abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

journal_title：British journal of cancer

authors： Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

更新日期：1992-02-01 00:00:00

abstract：:High experienced continuity of care in patients with cancer is associated with lower needs for care, better quality of life and better psychological outcomes. We developed and evaluated an intervention to improve experienced continuity. The intervention, consisted of (1) a 17-item patient-completed continuity assessme...

journal_title：British journal of cancer

authors： King M,Jones L,McCarthy O,Rogers M,Richardson A,Williams R,Tookman A,Nazareth I

更新日期：2009-01-27 00:00:00

abstract：:Prolactin (PRL) has been reported to inhibit apoptosis in various cell types and to serve as a cofactor in the upregulation of CD25 on T cells during activation. We investigated a possible relation between prolactin receptor (PRL-R) or IL-2 receptor alpha (IL-2Ralpha, CD25) expression on circulating T lymphocytes and ...

journal_title：British journal of cancer

authors： Bauernhofer T,Kuss I,Friebe-Hoffmann U,Baum AS,Dworacki G,Vonderhaar BK,Whiteside TL

更新日期：2003-04-22 00:00:00

abstract：:We analysed antibodies specific for human p53 in sera from primary breast cancer patients using three different immunoassays and we related these results to the p53 level in tumour tissue detected by immunohistochemistry. Only 44% (11/25) of apparently enzyme-linked immunosorbent assay (ELISA)-positive sera were from ...

journal_title：British journal of cancer

authors： Vojtesek B,Kovarik J,Dolezalova H,Nenutil R,Havlis P,Brentani RR,Lane DP

更新日期：1995-06-01 00:00:00

abstract：:The traditional cancer drug development pathway is increasingly being superseded by trials that address multiple clinical questions. These are collectively termed Complex Innovative Design (CID) trials. CID trials not only assess the safety and toxicity of novel anticancer medicines but also their efficacy in biomarke...

journal_title：British journal of cancer

authors： Blagden SP,Billingham L,Brown LC,Buckland SW,Cooper AM,Ellis S,Fisher W,Hughes H,Keatley DA,Maignen FM,Morozov A,Navaie W,Pearson S,Shaaban A,Wydenbach K,Kearns PR,Experimental Cancer Medicine Centres (ECMC) CID trials wo

更新日期：2020-02-01 00:00:00

abstract：:The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behaviour by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized. We have studied the prognostic significance of s...

journal_title：British journal of cancer

authors： Anttonen A,Kajanti M,Heikkilä P,Jalkanen M,Joensuu H

更新日期：1999-02-01 00:00:00

abstract：:In this review, we discuss the recent identification in vivo of a population of CD11c+ cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into func...

journal_title：British journal of cancer

authors： Coukos G,Benencia F,Buckanovich RJ,Conejo-Garcia JR

更新日期：2005-04-11 00:00:00

abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...

journal_title：British journal of cancer

authors： Bansal GS,Cox HC,Marsh S,Gomm JJ,Yiangou C,Luqmani Y,Coombes RC,Johnston CL

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:New therapeutic options for metastatic pancreatic cancer are urgently needed. In pancreatic cancer, overexpression of the epidermal growth factor receptor 2 (HER2) has been reported in up to 45%. This multicentre phase II study investigated the efficacy and toxicity of the HER2 antibody trastuzumab combined ...

journal_title：British journal of cancer

authors： Harder J,Ihorst G,Heinemann V,Hofheinz R,Moehler M,Buechler P,Kloeppel G,Röcken C,Bitzer M,Boeck S,Endlicher E,Reinacher-Schick A,Schmoor C,Geissler M

更新日期：2012-03-13 00:00:00

abstract：:PEP005 is a novel ingenol angelate that modulates protein kinases C (PKC) functions by activating PKC delta and inhibiting PKC alpha. This study assessed the antiproliferative effects of PEP005 alone and in combination with several other anticancer agents in a panel of 10 human cancer cell lines characterised for expr...

journal_title：British journal of cancer

authors： Benhadji KA,Serova M,Ghoul A,Cvitkovic E,Le Tourneau C,Ogbourne SM,Lokiec F,Calvo F,Hammel P,Faivre S,Raymond E

更新日期：2008-12-02 00:00:00

abstract：:Bleomycin is a chemotherapuetic drug used primarily in the treatment of squamous-cell carcinoma, while misonidazole is an effective radiosensitizer and potent cytotoxic agent selectively affecting hypoxic cells. V79 Chinese hamster cells were used to investigate the cytotoxicity of bleomycin (BLM) under aerated and hy...

journal_title：British journal of cancer

authors： Roizin-Towle L,Hall EJ

更新日期：1978-02-01 00:00:00

abstract：:Recently, we have found a high frequency of p53 gene mutations in human functional adrenal tumours. As the tumorigenesis is a multigene defect, we believe that other oncogenes may also be involved in the initiation or progression of adrenal tumours. Using the single-strand conformational polymorphism (SSCP) method, we...

journal_title：British journal of cancer

authors： Lin SR,Tsai JH,Yang YC,Lee SC

更新日期：1998-04-01 00:00:00

abstract：BACKGROUND:Systemic failure remains a challenge in rectal cancer. We investigated the possible systemic anti-tumour immune activity invoked within oxaliplatin-based neoadjuvant therapy. METHODS:In two high-risk patient cohorts, we assessed the circulating levels of the fms-like tyrosine kinase 3 ligand (Flt3L), a fact...

journal_title：British journal of cancer

authors： Kalanxhi E,Meltzer S,Schou JV,Larsen FO,Dueland S,Flatmark K,Jensen BV,Hole KH,Seierstad T,Redalen KR,Nielsen DL,Ree AH

更新日期：2018-05-01 00:00:00

abstract：:The importance of tumour angiogenesis in the process of tumour growth and progression in solid tumours has been widely accepted. Among many angiogenic factors, vascular endothelial growth factor (VEGF) has been shown to play a major role in the development and dissemination of the malignant tumours. Nitric oxide (NO) ...

journal_title：British journal of cancer

authors： Eroğlu A,Demirci S,Ayyildiz A,Kocaoğlu H,Akbulut H,Akgül H,Elhan HA

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:PI3K/Akt (PKB) pathway has been shown in several cell types to be activated by ligands to cell surface integrins, leading to the metastasis of tumour cells. The signalling pathways involved in the metastatic spread of human scirrhous gastric carcinoma cells have not been defined. METHODS:The role of the PI3...

journal_title：British journal of cancer

authors： Matsuoka T,Yashiro M,Nishioka N,Hirakawa K,Olden K,Roberts JD

更新日期：2012-04-24 00:00:00

abstract：:To test the anti-tumour activity of rhizoxin in recurrent and/or metastatic squamous cell head and neck cancer, we performed a phase II study. Eligibility required histologically proven squamous cell head and neck cancer. Patients could only have received one prior chemotherapy. Patients were entered if WHO PS was < o...

journal_title：British journal of cancer

authors： Verweij J,Wanders J,Gil T,Schöffski P,Catimel G,te Velde A,de Mulder PH

更新日期：1996-02-01 00:00:00

abstract：:Acquired drug resistance is a major problem in cancer treatment. To explore the genes involved in chemosensitivity and resistance, 10 human tumour cell lines, including parental cells and resistant subtypes selected for resistance against doxorubicin, melphalan, teniposide and vincristine, were profiled for mRNA expre...

journal_title：British journal of cancer

authors： Rickardson L,Fryknäs M,Dhar S,Lövborg H,Gullbo J,Rydåker M,Nygren P,Gustafsson MG,Larsson R,Isaksson A

更新日期：2005-08-22 00:00:00

abstract：:The objective of this study was to prospectively measure peri-diagnostic and surgical time intervals for patients with suspected colorectal, lung, or prostate cancer. Prospective eligible patients were referred to a regional hospital in Ottawa, Canada between February 2004 and February 2005 for diagnostic assessment o...

journal_title：British journal of cancer

authors： Grunfeld E,Watters JM,Urquhart R,O'Rourke K,Jaffey J,Maziak DE,Morash C,Patel D,Evans WK

更新日期：2009-01-13 00:00:00

abstract：:We evaluated the risk of bladder cancer in a cohort of 79,280 Swedish men hospitalised for benign prostatic hyperplasia (BPH), identified in the Swedish Inpatient Register between 1964 and 1983 and followed until 1989 via multiple record linkages with nationwide data on cancer registry, death and emigration. Standardi...

journal_title：British journal of cancer

authors： Kang D,Chokkalingam AP,Gridley G,Nyren O,Johansson JE,Adami HO,Silverman D,Hsing AW

更新日期：2007-05-07 00:00:00

abstract：:Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...

journal_title：British journal of cancer

authors： Nicoletti G,De Giovanni C,Landuzzi L,Simone G,Rocchi P,Nanni P,Lollini PL

更新日期：1992-04-01 00:00:00

abstract：:Secular, socioeconomic and urban-rural gradients and geographical differences in beef and fat consumption within the United States of America are compared with corresponding data on colorectal cancer incidence and mortality rates. These results, together with the results of most previous epidemiological studies, appea...

journal_title：British journal of cancer

authors： Enstrom JE

更新日期：1975-10-01 00:00:00

abstract：:Ninety-two consecutive adult patients admitted with acute life-threatening complications of haematological malignancy were studied to determine long term outcome. The quality of life was evaluated in seven long term survivors who are currently alive more than 1 year after hospital discharge using three validated metho...

journal_title：British journal of cancer

authors： Yau E,Rohatiner AZ,Lister TA,Hinds CJ

更新日期：1991-11-01 00:00:00

abstract：:Using a recently developed model for studying the biology of locally recurrent (LR) mammary tumours in the 13762NF rat mammary adenocarcinoma system, we examined the sensitivity to polymorphonuclear cell, macrophage and natural killer cell cytolysis. The parental MTF7(T20) cell line; the 'primary' tumours which arose ...

journal_title：British journal of cancer

authors： Aeed PA,Welch DR

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:A remarkably better prognosis is associated with oropharyngeal squamous cell carcinomas (OPSCC) driven by human papillomaviruses (HPV) compared with HPV-negative OPSCC. Consequently, de-escalation of standard treatment has been suggested. Due to modest specificity rates, debates are ongoing, whether p16INK4a...

journal_title：British journal of cancer

authors： Wagner S,Prigge ES,Wuerdemann N,Reder H,Bushnak A,Sharma SJ,Obermueller T,von Knebel Doeberitz M,Dreyer T,Gattenlöhner S,Wolf G,Pons-Kühnemann J,Wittekindt C,Klussmann JP

更新日期：2020-09-01 00:00:00

abstract：BACKGROUND:Wnt-signalling has an important role in renal cancer and it is modulated by genistein in other cancers. Recently, microRNAs (miRNAs) have emerged as new regulators of gene expression. Thus, we focused on miRNAs to examine the regulatory mechanism of genistein on the Wnt-signalling pathway in renal cell carci...

journal_title：British journal of cancer

authors： Hirata H,Ueno K,Nakajima K,Tabatabai ZL,Hinoda Y,Ishii N,Dahiya R

更新日期：2013-05-28 00:00:00

abstract：:The matrix metalloprotease MMP-9 localizes to tumour-associated macrophages in human ovarian cancer but little is known of its regulation. Co-culture of human ovarian cancer cells (PEO-1) and a monocytic cell line (THP-1) led to production of 92-kDa proMMP-9. PEO-1-conditioned medium (CM) also stimulated THP-1 cells o...

journal_title：British journal of cancer

authors： Leber TM,Balkwill FR

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:A frequent mechanism of acquired multidrug resistance in human cancers is overexpression of ATP-binding cassette transporters such as the Multi-Drug Resistance Protein 1 (MDR-1). Nutlin-3, an MDM2-p53 antagonist, has previously been reported to be a competitive MDR-1 inhibitor. METHODS:This study assessed w...

journal_title：British journal of cancer

authors： Chen L,Zhao Y,Halliday GC,Berry P,Rousseau RF,Middleton SA,Nichols GL,Del Bello F,Piergentili A,Newell DR,Lunec J,Tweddle DA

更新日期：2014-08-12 00:00:00

abstract：:Combinations of dacarbazine (DTIC) and other cytotoxic agents or alpha-interferon were given to 136 patients in five different regimens. The total response rate was 32% (95% confidence interval 24-40%); 13% had a complete remission. Female patients had a significantly higher chance of response than male patients: 46% ...

journal_title：British journal of cancer

authors： Mulder NH,van der Graaf WT,Willemse PH,Koops HS,de Vries EG,Sleijfer DT

更新日期：1994-10-01 00:00:00

abstract：:Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The mAbs (three IgG2b a...

journal_title：British journal of cancer

authors： Modjtahedi H,Styles JM,Dean CJ

更新日期：1993-02-01 00:00:00