Multicentre phase II trial of trastuzumab and capecitabine in patients with HER2 overexpressing metastatic pancreatic cancer.

abstract：:The tolerability, anti-tumour activity and pharmacokinetic interaction of high-dose intravenous cyclosporin combined with intravenous etoposide was evaluated in children. Eighteen patients with recurrent or refractory tumours, all of whom had previously received etoposide, were treated with a combination of high-dose ...

journal_title：British journal of cancer

authors： Bisogno G,Cowie F,Boddy A,Thomas HD,Dick G,Pinkerton CR

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the safety and efficacy of dose-dense weekly chemotherapy, followed by resection and/or thoracic radiotherapy. METHODS:Patients with histologically documented thymoma with unresectable stage III disease received 9 weeks of chemotherapy: cisplatin 25 mg m(-2) on weeks 1-9; vincri...

journal_title：British journal of cancer

authors： Kunitoh H,Tamura T,Shibata T,Takeda K,Katakami N,Nakagawa K,Yokoyama A,Nishiwaki Y,Noda K,Watanabe K,Saijo N,JCOG Lung Cancer Study Group.

更新日期：2010-06-29 00:00:00

abstract：BACKGROUND:Recently, many studies have suggested a possible adjuvant role of aspirin in colorectal cancer, reporting a positive prognostic effect with its use in patients with established disease. The aim of this study was to investigate the anticancer effect of aspirin use during preoperative chemoradiation for rectal...

journal_title：British journal of cancer

authors： Restivo A,Cocco IM,Casula G,Scintu F,Cabras F,Scartozzi M,Zorcolo L

更新日期：2015-10-20 00:00:00

abstract：:Fine needle aspiration (FNA) biopsy is the least invasive method of sampling breast cancer in vivo and provides material for breast cancer diagnosis. FNA has also been used to examine cellular markers to predict and monitor the effects of therapy. The aim of this study was to assess the accuracy of using FNA material ...

journal_title：British journal of cancer

authors： Ball HM,Hupp TR,Ziyaie D,Purdie CA,Kernohan NM,Thompson AM

更新日期：2001-10-19 00:00:00

abstract：:Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...

journal_title：British journal of cancer

authors： Shetty G,Kendall C,Shepherd N,Stone N,Barr H

更新日期：2006-05-22 00:00:00

abstract：:Recent evidence has demonstrated that endothelial-to-mesenchymal transition (EndMT) may have a significant role in a number of diseases. Although EndMT has been previously studied as a critical process in heart development, it is now clear that EndMT can also occur postnatally in various pathologic settings, including...

journal_title：British journal of cancer

authors： Potenta S,Zeisberg E,Kalluri R

更新日期：2008-11-04 00:00:00

abstract：BACKGROUND:PEP02, also known as MM-398, is a novel nanoliposomal irinotecan that has improved pharmacokinetics and tumour bio-distribution of the free drug. This phase 2 study evaluated PEP02 monotherapy as second-line treatment for pancreatic cancer. METHODS:Patients who had metastatic pancreatic adenocarcinoma, Karn...

journal_title：British journal of cancer

authors： Ko AH,Tempero MA,Shan YS,Su WC,Lin YL,Dito E,Ong A,Wang YW,Yeh CG,Chen LT

更新日期：2013-08-20 00:00:00

abstract：BACKGROUND:The aim was to evaluate whether this gastric cancer-screening programme was effective in reducing oesophageal cancer mortality. METHODS:A population-based retrospective cohort study was conducted using the Korean National Cancer Screening Programme (NCSP) database. The study cohort comprised 16,969 oesophag...

journal_title：British journal of cancer

authors： Kim JH,Han KD,Lee JK,Kim HS,Cha JM,Park S,Kim JS,Kim WH,Big Data Research Group (BDRG) of the Korean Society of Gastroenterology (KSG).

更新日期：2020-08-01 00:00:00

abstract：:In 1977 a number of patients with soft-tissue sarcomas and previous exposure to phenoxyacetic acids were described. Following from these observations a matched case-control study was made. Exposure to chlorophenols was also included in this study. The results showed that exposure to phenoxyacetic acids or chlorophenol...

journal_title：British journal of cancer

authors： Hardell L,Sandström A

更新日期：1979-06-01 00:00:00

abstract：:Exposure to the fibrous mineral erionite is known to induce mesothelioma in man and laboratory animals. Previous studies demonstrated the presence of a trypsin-like protease associated with tumour cells. This protease could be demonstrated by the use of fluorescent probes which located cells possessing this enzyme. We...

journal_title：British journal of cancer

authors： Steven FS,Hill RJ

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:There is a need for sensitive and specific blood-borne markers for the detection of gastric cancer. Raised serum macrophage inhibitory factor (MIF) levels have been proposed as a marker for gastric cancer diagnosis but, to date, studies have only encompassed patients from high-incidence areas. METHODS:We ha...

journal_title：British journal of cancer

authors： Shimwell NJ,Ward DG,Mohri Y,Mohri T,Pallan L,Teng M,Miki YC,Kusunoki M,Tucker O,Wei W,Morse J,Johnson PJ

更新日期：2012-10-23 00:00:00

abstract：:Recently, apoptosis has been implicated as one of the end points of cells exposed to chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in chemotherapy-induced apoptosis, but in a cell type-dependent manner. We sought to determine the roles played by the p53 and Bcl-2 family of proteins in 5-fl...

journal_title：British journal of cancer

authors： Nita ME,Nagawa H,Tominaga O,Tsuno N,Fujii S,Sasaki S,Fu CG,Takenoue T,Tsuruo T,Muto T

更新日期：1998-10-01 00:00:00

abstract：:The relationship between colony numbers and concentration of cells plated is an important parameter of clonogenic assay systems. The cloning efficiency for an ideal sample should be independent of cell concentration, thus giving a straight line through the origin when colony numbers are plotted against cell concentrat...

journal_title：British journal of cancer

authors： Eliason JF,Aapro MS,Decrey D,Brink-Petersen M

更新日期：1985-09-01 00:00:00

abstract：:The ten most frequently reported pretreatment symptoms on the Rotterdam Symptom Checklist, which was completed by more than 650 patients entering two MRC Lung Cancer Working Party multicentre randomised trials, included general symptoms (tiredness, lack of appetite) and psychological distress (worry, anxiety) in addit...

journal_title：British journal of cancer

authors： Hopwood P,Stephens RJ

更新日期：1995-03-01 00:00:00

abstract：:We have shown previously that the relative expression of a truncated oestrogen receptor-alpha variant mRNA (ER clone 4) is significantly increased in axillary node-positive primary breast tumours compared with node-negative tumours. In this study, we have examined the relative expression of clone 4-truncated, exon 5-d...

journal_title：British journal of cancer

authors： Leygue E,Hall RE,Dotzlaw H,Watson PH,Murphy LC

更新日期：1999-02-01 00:00:00

abstract：:Foetal acinar components associated with the development of the hamster pancreas have been previously defined with the aid of an antifoetal pancreas serum. In immunohistology this antiserum also stained malignant ductal cells in N-nitrobis (2-oxopropyl) amine (BOP)-induced pancreatic adenocarcinoma. It did not stain a...

journal_title：British journal of cancer

authors： Escribano MJ,Carré-Llopis A,Loridon-Rosa B

更新日期：1985-02-01 00:00:00

abstract：:This study has been designed to verify the specific toxicity of saporin, a type 1 ribosome-inactivating protein (RIP), with the same activity as ricin A chain, targeted by a bispecific monoclonal antibody (bimAb) recognising both the CD25 antigen and the RIP. The CD25 antigen is expressed by lymphoid populations upon ...

journal_title：British journal of cancer

authors： Tazzari PL,Zhang S,Chen Q,Sforzini S,Bolognesi A,Stirpe F,Xie H,Moretta A,Ferrini S

更新日期：1993-06-01 00:00:00

abstract：:The relationship between hormone replacement treatment (HRT) and breast cancer risk was analysed using data from a case-control study conducted between June 1991 and February 1994 in six Italian centres on 2569 patients aged below 75 with histologically confirmed breast cancer and 2588 controls admitted to hospital fo...

journal_title：British journal of cancer

authors： La Vecchia C,Negri E,Franceschi S,Favero A,Nanni O,Filiberti R,Conti E,Montella M,Veronesi A,Ferraroni M

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Pre-existing non-cancer conditions may complicate and delay colorectal cancer diagnosis. METHOD:Incident cases (aged ⩾40 years, 2007-2009) with colorectal cancer were identified in the Clinical Practice Research Datalink, UK. Diagnostic interval was defined as time from first symptomatic presentation of col...

journal_title：British journal of cancer

authors： Mounce LTA,Price S,Valderas JM,Hamilton W

更新日期：2017-06-06 00:00:00

abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...

journal_title：British journal of cancer

authors： Pisani P,Forman D

更新日期：2004-02-09 00:00:00

abstract：:The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...

journal_title：British journal of cancer

authors： Kitamura S,Kondo S,Shinomura Y,Kanayama S,Miyazaki Y,Kiyohara T,Hiraoka S,Matsuzawa Y

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

journal_title：British journal of cancer

authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

更新日期：2012-01-17 00:00:00

abstract：:As regulators of malignant cell behaviour and communication with stroma, cytokines have proved useful in understanding cancer biology and developing novel therapies. In renal cell carcinoma, patients with inflammatory reactions are known to have poor prognosis. In order to elucidate the relation between renal cell car...

journal_title：British journal of cancer

authors： Yoshida N,Ikemoto S,Narita K,Sugimura K,Wada S,Yasumoto R,Kishimoto T,Nakatani T

更新日期：2002-05-06 00:00:00

abstract：:The pp125 focal adhesion kinase (FAK) is involved in integrin-mediated cell signalling and overexpressed in a variety of solid tumours. Focal adhesion kinase expression has been correlated to invasion and metastasis, but the data on breast cancer are inconclusive. We analysed FAK mRNA, protein levels and expression pa...

journal_title：British journal of cancer

authors： Watermann DO,Gabriel B,Jäger M,Orlowska-Volk M,Hasenburg A,zur Hausen A,Gitsch G,Stickeler E

更新日期：2005-09-19 00:00:00

abstract：:In the present study we have used flow cytometric DNA measurements on synchronised human NHIK 3025 cells to measure cell cycle progression under various conditions of reduced oxygenation. Our data indicate that addition of 0.1 mM deoxycytidine or uridine has no effect on the oxygen-dependent arrest in late G1 or on th...

journal_title：British journal of cancer

authors： Amellem O,Löffler M,Pettersen EO

更新日期：1994-11-01 00:00:00

abstract：:Fibroblast growth factors (FGFs) and fibroblast growth factor receptors (FGFRs) have been increasingly recognized to play an important role in the pathobiology of pancreatic malignancy. We have investigated the effects of FGF-1 and FGF-2 on the behaviour and adhesion properties of human pancreatic adenocarcinoma cell ...

journal_title：British journal of cancer

authors： El-Hariry I,Pignatelli M,Lemoine NR

更新日期：2001-06-15 00:00:00

abstract：:Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 c...

journal_title：British journal of cancer

authors： Thein SL,Jeffreys AJ,Gooi HC,Cotter F,Flint J,O'Connor NT,Weatherall DJ,Wainscoat JS

更新日期：1987-04-01 00:00:00

abstract：:Over a 10 year period, between 1974-1984, 257 adult cases of tissue sarcoma have been evaluated in the Department of Medical Oncology, Christie Hospital, Manchester. At registration locally advanced or metastatic diseases was present in 162 (63%). The male/female ratio was 1.5:1 and median age 54 years (range 14-85). ...

journal_title：British journal of cancer

authors： Bramwell VH,Crowther D,Deakin DP,Swindell R,Harris M

更新日期：1985-03-01 00:00:00

abstract：:Breast cancer is the second most common cancer among women in Madras and southern India after cervix cancer. The Madras Metropolitan Tumour Registry (MMTR), a population-based cancer registry, collects data on the outcome of cancer diagnosis by both active and passive methods. A total of 2080 cases of invasive female ...

journal_title：British journal of cancer

authors： Gajalakshmi CK,Shanta V,Swaminathan R,Sankaranarayanan R,Black RJ

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-...

journal_title：British journal of cancer

authors： Bessell EM,Bouliotis G,Armstrong S,Baddeley J,Haynes AP,O'Connor S,Nicholls-Elliott H,Bradley M

更新日期：2012-07-24 00:00:00