Abstract：
BACKGROUND:The Nottinghamshire Lymphoma Registry contains the details of all the patients diagnosed with lymphoma (since 1 January 1973) within a defined geographical area with a population of 1.1 million. It was therefore possible to study the outcome of treatment for Hodgkin's disease for three 10-year cohorts (1973-1982, 1983-1992 and 1993-2002).The aims of the study were to compare survival time among the three patient cohorts, to identify prognostic factors and to estimate relative survival. METHODS:A total of 745 patients diagnosed between 1973 and 2002 were analysed for survival. Survivorship was estimated by the Kaplan-Meier method and parametric survival models. An accelerated failure-time regression was used for multivariate analysis. RESULTS:Overall, patients were observed for 9.8 (0.3-34.82) years (median(range)), on average. One, five and fifteen-year disease-specific survival was found to be 87% (85-90%), 77% (74-80%) and 70% (67-74%), respectively. For those for diagnosed between 1973 and 1982, the 15-year survival was found to be 57%; for 1983-1992, it was 74% and for 1993-2002, it was 83% (P<0.001). The difference remained significant after adjusting for prognostic factors. The actuarial risk of developing a second malignancy at 20 years was for the 1973-1982 cohort, 12.4%, and for the 1983-1992 cohort, 18.8%. CONCLUSION:Treatment advances and effective management of toxicities of treatment over time, have resulted in a significantly longer survival for patients with Hodgkin's disease diagnosed within a defined population.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Bessell EM,Bouliotis G,Armstrong S,Baddeley J,Haynes AP,O'Connor S,Nicholls-Elliott H,Bradley Mdoi
10.1038/bjc.2012.228subject
Has Abstractpub_date
2012-07-24 00:00:00pages
531-6issue
3eissn
0007-0920issn
1532-1827pii
bjc2012228journal_volume
107pub_type
杂志文章abstract：:Forty-one human tumour cell lines were examined for the production of epidermal growth factor (EGF)/transforming growth factor (TGF)-alpha-like activity (EGF/TGF-alpha-LA), immunoreactive (IR-) EGF and IR-TGF-alpha. EGF/TGF-alpha-LA was determined by radioreceptor assay, in which the factors with capacity to bind to E...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.159
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1979.200
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abstract：:In a population-based cohort study of all women aged over 50 years with breast cancer in the Swedish Cancer Register in 1961-2003, those diagnosed before 31 December 1987 were regarded as unexposed to tamoxifen, whereas those diagnosed after that date were considered potentially exposed. Crosslinkages within the Cance...
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pub_type： 杂志文章,多中心研究
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abstract：:Functionally active telomerase is affected at various steps including transcriptional and post-transcriptional levels of major telomerase components (hTR and human telomerase reverse transcriptase (hTERT)). We therefore developed a rapid and sensitive method to quantify hTERT and its splicing variants as well as the h...
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 杂志文章
doi：10.1038/sj.bjc.6604963
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pub_type： 临床试验,杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.232
更新日期：2013-05-28 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1996.434
更新日期：1996-09-01 00:00:00
abstract：BACKGROUND:Complete tumour response (pCR) to neo-adjuvant chemo-radiotherapy for rectal cancer is associated with a reduction in local recurrence and improved disease-free and overall survival, but is achieved in only 20-30% of patients. Drug repurposing for anti-cancer treatments is gaining momentum, but the potential...
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pub_type： 杂志文章,meta分析
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更新日期：2017-07-11 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.109
更新日期：1993-03-01 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1986.270
更新日期：1986-12-01 00:00:00
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pub_type： 杂志文章,随机对照试验
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journal_title：British journal of cancer
pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：British journal of cancer
pub_type： 杂志文章
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journal_title：British journal of cancer
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更新日期：2007-01-15 00:00:00
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journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605367
更新日期：2009-12-01 00:00:00
