Abstract：
:To clarify the mechanism of acquired CDDP resistance in ovarian cancer, we compared the microsatellite instability (MSI) by the amplification of 10 microsatellite loci and immunohistochemical detection of hMSH2 and hMLH1 expression between the primary resected tumours and the secondary resected residual tumours after 5 or 6 courses of CDDP-based chemotherapy in the 24 cases of ovarian cancer. Of the 24 primary resected tumours, 9 (37.5%) showed MSI (7 cases of MSI-L, 2 cases of MSI-H), while 15 (72.5%) were microsatellite stable tumours (MSS). The primary tumours also had MSI in the residual tumours after CDDP-based chemotherapy. However, all of the cases with MSS in the primary resected tumours exhibited MSI (2 cases were MSI-L, and 13 cases were MSI-H) in the residual tumours after CDDP-based chemotherapy (P< 0.001). Furthermore, 11 (73.3%) of these cases which changed from MSS to MSI also had a change in the expression of hMLH1 from positive to undetectable (P< 0.001). Our data suggest that tumour MSI changes during CDDP-based chemotherapy, and that the loss of hMLH1 expression is one of the factors that has the greatest effect on this transformation.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Watanabe Y,Koi M,Hemmi H,Hoshai H,Noda Kdoi
10.1054/bjoc.2001.2037subject
Has Abstractpub_date
2001-09-28 00:00:00pages
1064-9issue
7eissn
0007-0920issn
1532-1827pii
6692037journal_volume
85pub_type
杂志文章abstract：:The records of 610 consecutive patients with small cell lung cancer, treated on a common protocol in a multicentre trial, were reviewed and 24 (4%) cases of spinal cord compression identified. Five hundred patients had isotope bone scans performed at presentation, and in 131 (26%) there was abnormal isotope uptake in ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.119
更新日期：1989-04-01 00:00:00
abstract：:To assess the precise role of IGF1 in benign and malignant breast diseases, we analysed the tissular localisation, characterised, and quantified specific insulin-like growth factor 1 (IGF1) binding sites in these heterogenous tissues, using histo-autoradiographic analysis (HAA). The 125I-IGF1 binding was performed on ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.252
更新日期：1992-08-01 00:00:00
abstract：:Four-hundred-forty-five husbands of women with invasive cervical carcinoma, 165 of women with in situ cervical cancer, and 717 of control women (age range 19-82 years) were interviewed and a sample of exfoliated cells from the penis obtained in seven case-control studies conducted by the International Agency for Resea...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600194
更新日期：2002-03-04 00:00:00
abstract：BACKGROUND:Melatonin induces apoptosis in many different cancer cell lines, including hepatocellular carcinoma cells. However, the responsible pathways have not been clearly elucidated. A member of the forkhead transcription factors' family, FoxO3a, has been implicated in the expression of the proapoptotic protein Bim ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.563
更新日期：2013-02-05 00:00:00
abstract：:Lipoxygenase metabolites of arachidonic acid can act as growth promoting factors for various cancer cell lines. Here we demonstrate that the 5-lipoxygenase inhibitor nordihydroguaiaretic acid potently inhibits anchorage-independent growth of human pancreatic and cervical cancer cells in soft agar and delays growth of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600186
更新日期：2002-04-08 00:00:00
abstract：:Despite expressing both Fas and Fas ligand, DU145 and LNCaP prostate cancer cells were resistant to anti-Fas-induced cell death. Resistance to Fas-mediated cytotoxicity could be overcome in DU145, but not in LNCaP, cells by pretreating cells with sublethal doses of cytotoxic drugs, such as camptothecin. Activated casp...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690365
更新日期：1999-05-01 00:00:00
abstract：BACKGROUND:Older women have lower breast cancer surgery rates than younger women. UK policy states that differences in cancer treatment by age can only be justified by patient choice or poor health. METHODS:We investigate whether lack of surgery for older patients is explained by patient choice/poor health in a prospe...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.734
更新日期：2014-02-04 00:00:00
abstract：:A set of monoclonal antibodies was constructed by immunising mice with peptide fragments of the c-myc oncogene product. One such antibody, Myc 1-6E10 was shown to bind to a 62,000 dalton protein identifiable with the c-myc product (p62c-myc). The antigen recognised was not destroyed by paraffin wax embedding. Myc 1-6E...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1985.174
更新日期：1985-08-01 00:00:00
abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2013.188
更新日期：2013-05-28 00:00:00
abstract：:The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602248
更新日期：2004-12-13 00:00:00
abstract：:In a clinical investigation of observed postoperative survival, 563 patients have been registered for primary surgical treatment of colorectal cancer since 1974. The potential prognostic factors examined within the first days of hospitalization for primary resection included age of the patients, operability, location ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.250
更新日期：1981-11-01 00:00:00
abstract：BACKGROUND:There are currently two million cancer survivors in the United Kingdom, and in recent years this number has grown by 3% per annum. The aim of this paper is to provide long-term projections of cancer prevalence in the United Kingdom. METHODS:National cancer registry data for England were used to estimate can...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.366
更新日期：2012-09-25 00:00:00
abstract：:The relationship of cytogenetic changes with the acquisition of an indefinite life span in vitro, the ability of cells to grow in soft agar and their tumourigenicity in syngeneic animals has been studied in control, trans-7,8-dihydrodiolbenzo(a)pyrene and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrah...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1984.159
更新日期：1984-08-01 00:00:00
abstract：:This study was planned to evaluate the feasibility of mouth self-examination (MSE). Some 450 college students distributed to 9000 households a brochure describing the risk factors of oral cancer, the appearance of premalignant and malignant lesions of the oral cavity and the methods of MSE with pictures. All subjects ...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/bjc.1995.81
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.376
更新日期：2016-12-06 00:00:00
abstract：:The expression of peroxisome proliferator-activated receptor (PPAR)gamma in thyroid neoplasias and in normal thyroid (NT) tissues has not been fully investigated. The objectives of the present work were: to study and compare the relative expression of PPARgamma in normal, benign and malignant thyroid tissues and to co...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601989
更新日期：2004-08-16 00:00:00
abstract：BACKGROUND:Rectal bleeding is a recognised early symptom of colorectal cancer. This study aimed to assess the diagnostic accuracy of symptoms, signs and diagnostic tests in patients with rectal bleeding in relation to risk of colorectal cancer in primary care. METHODS:Diagnostic accuracy systematic review. Medline (19...
journal_title：British journal of cancer
pub_type： 杂志文章,meta分析,评审
doi：10.1038/sj.bjc.6605426
更新日期：2010-01-05 00:00:00
abstract：:I.p. or i.v. administration of Corynebacterium parvum (CP) to MF1 mice induces a generalized inflammatory response, associated with marked hepatosplenomegaly and accompanied by a pronounced granulomatous response in the liver. Injection of the Landschütz ascites carcinoma (LAC) 24 h after CP substantially reduced the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1982.97
更新日期：1982-04-01 00:00:00
abstract：:The evidence base for head and neck cancers is low with relatively few randomized controlled trials of the two main treatments, surgery and radiotherapy. The aim of the study was to investigate the patterns of surgery and radiotherapy treatment for head and neck cancers in three large areas of England and to investiga...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6690695
更新日期：1999-09-01 00:00:00
abstract：BACKGROUND:Tumour carbonic anhydrase IX (CAIX), a hypoxia-inducible tumour-associated cell surface enzyme, is thought to acidify the tumour microenvironment by hydrating CO2 to form protons and bicarbonate, but there is no definitive evidence for this in solid tumours in vivo. METHODS:We used 1H magnetic resonance spe...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0216-5
更新日期：2018-08-01 00:00:00
abstract：:Antibody drug conjugates (ADCs) employ the exquisite specificity of tumour-specific monoclonal antibodies (mAb) for the targeted delivery of highly potent cytotoxic drugs to the tumour site. The chemistry of the linker, which connects the drug to the mAb, determines how and when the drug is released from the mAb. This...
journal_title：British journal of cancer
pub_type： 杂志文章,评审
doi：10.1038/bjc.2017.367
更新日期：2017-12-05 00:00:00
abstract：:Thirty-eight patients with previously treated Hodgkin's disease were given high dose combination chemotherapy using melphalan and BCNU and autologous bone marrow transplantation. In 25 patients etoposide was added in conventional dosage. During the course of the study the dose of melphalan was increased from 80 to 140...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1989.128
更新日期：1989-04-01 00:00:00
abstract：:The clearance of an intradermally-injected solution of 133Xenon in 0.9% saline has been used to study the impairment and recovery of blood flow in mouse tail for 5 days following photodynamic therapy (PDT) with 2mg TPPS i.v. per mouse and a range of doses of white light. Impairment of blood flow was observed within 10...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.105
更新日期：1988-05-01 00:00:00
abstract：BACKGROUND:Gastroesophageal adenocarcinoma (GOA) has poor clinical outcomes and lacks reliable blood markers. Here we present circulating tumour DNA (ctDNA) as an emerging biomarker. METHODS:Forty patients (17 palliative and 23 curative) were followed by serial plasma monitoring. Primary tumour DNA was analysed by tar...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-1002-8
更新日期：2020-10-01 00:00:00
abstract：:Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.2001.2099
更新日期：2001-11-02 00:00:00
abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600585
更新日期：2002-10-21 00:00:00
abstract：:At baseline, weight-losing pancreatic cancer patients (n=7) had lower leptin (P<0.05) but higher cortisol, interleukin-6, resting energy expenditure and fat oxidation than healthy subjects (n=6, P<0.05). Over a 4 h feeding period, the areas under the curve for glucose, cortisol and interleukin-6 were greater (P<0.05),...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6601712
更新日期：2004-03-22 00:00:00
abstract：:The expression of urokinase-type plasminogen activator (u-PA), u-PA receptor (u-PAR) and plasminogen activator inhibitor (PAI) 1 and 2 was examined in 105 cases of primary lung cancer tissue using immunohistochemical staining and reverse transcriptase polymerase chain reaction (RT-PCR) techniques. The expression of u-...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1998.588
更新日期：1998-09-01 00:00:00
abstract：:In addition to cobalt, metallic nickel, cadmium and other metals (e.g. zinc and copper) dissolve when incubated with horse serum at 37°. The dissolving property of copper in serum resembles that of cobalt, its solubility being increased greatly in the presence of oxygen, whereas the solubilities of cadmium, zinc and m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1972.38
更新日期：1972-08-01 00:00:00
abstract：BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used we...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.394
更新日期：2014-09-09 00:00:00
