The response of leptin, interleukin-6 and fat oxidation to feeding in weight-losing patients with pancreatic cancer.

abstract：:There is increasing evidence that essential fatty acids (EFA) may have a role to play in the aetiology of some types of cancer although their precise mode of action is unknown. Differences in the metabolism of EFA between patients with benign or malignant prostatic disease may help to elucidate their role in the latte...

journal_title：British journal of cancer

authors： Chaudry A,McClinton S,Moffat LE,Wahle KW

更新日期：1991-12-01 00:00:00

abstract：:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish t...

journal_title：British journal of cancer

authors： Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CS

更新日期：1994-06-01 00:00:00

abstract：:The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient surv...

journal_title：British journal of cancer

authors： Locker AP,Dowle CS,Ellis IO,Elston CW,Blamey RW,Sikora K,Evan G,Robins RA

更新日期：1989-11-01 00:00:00

abstract：:The incidence of nodal metastasis in early gastric carcinoma (EGC) is 10-20%. However, the optimal nodal dissection for early gastric carcinoma has not been established. A retrospective study was conducted in 392 consecutive patients who underwent potentially curative distal gastrectomy for EGC between 1962 and 1990. ...

journal_title：British journal of cancer

authors： Miwa K,Miyazaki I,Sahara H,Fujimura T,Yonemura Y,Noguchi M,Falla R

更新日期：1995-12-01 00:00:00

abstract：:The secosteroid hormones, all-trans- and 9-cis-retinoic acid and vitamin D3, have demonstrated significant capacity to control proliferation in vitro of many solid tumour cell lines. Cooperative synergistic effects by these two ligands have been reported, and it is, therefore, possible that greater therapeutic effects...

journal_title：British journal of cancer

authors： Campbell MJ,Park S,Uskokovic MR,Dawson MI,Jong L,Koeffler HP

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The accuracy of prostate-specific antigen (PSA) testing in prostate cancer detection is constrained by low sensitivity and specificity. Dysregulated expression of minichromosome maintenance (Mcm) 2-7 proteins is an early event in epithelial multistep carcinogenesis and thus MCM proteins represent powerful ca...

journal_title：British journal of cancer

authors： Dudderidge TJ,Kelly JD,Wollenschlaeger A,Okoturo O,Prevost T,Robson W,Leung HY,Williams GH,Stoeber K

更新日期：2010-08-24 00:00:00

abstract：:We evaluated the degree of tubular differentiation in 172 samples of invasive ductal breast cancer in order to determine numerical thresholds for histological breast cancer grading. The tubular differentiation in each sample was defined as the fraction of fields showing tubular differentiation (FTD). The analysis was ...

journal_title：British journal of cancer

authors： Kronqvist P,Kuopio T,Collan Y

更新日期：2000-05-01 00:00:00

abstract：BACKGROUND:The effectiveness of a therapeutic strategy that switches chemotherapy, based on Ki-67 tumour expression after initial therapy, relative to that of standard chemotherapy, has not been evaluated. METHODS:Patients were randomly assigned to the control arm or the Ki-67 response-guided arm (Ki-67 arm). Primary ...

journal_title：British journal of cancer

authors： Mukai H,Yamaguchi T,Takahashi M,Hozumi Y,Fujisawa T,Ohsumi S,Akabane H,Nishimura R,Takashima T,Park Y,Sagara Y,Toyama T,Imoto S,Mizuno T,Yamashita S,Fujii S,Uemura Y

更新日期：2020-06-01 00:00:00

abstract：:The novel compound 7(-)[4'-(2-nitroimidazol-l-yl)-butyl]-theophylline (NITP) can be used as an immunologically detectable probe for hypoxic cells. Because of the limited water solubility of NITP, it has been administered dissolved in peanut oil with 10% dimethylsulphoxide (DMSO). A new aqueous formulation has been dev...

journal_title：British journal of cancer

authors： Hodgkiss RJ,Stratford MR,Dennis MF,Hill SA

更新日期：1995-12-01 00:00:00

abstract：:Diagnosis of hereditary non-polyposis colorectal cancer (HNPCC) is currently based on phenotypical analysis of an expanded pedigree. Diagnostic guidelines ('Amsterdam criteria') proposed by the International Collaborative Group on HNPCC are often too stringent for use with small families. There is also the possibility...

journal_title：British journal of cancer

authors： Percesepe A,Anti M,Roncucci L,Armelao F,Marra G,Pahor M,Coco C,Gasbarrini G,Ponz de Leon M

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Clinical heterogeneity reflects the complexity of genetic events associated with neuroblastoma (NB). To identify the status of all described genetic loci with possible prognostic interest, high-throughput approaches have been used, but only with tumour cell content >60%. In some tumours, necrotic, haemorrhag...

journal_title：British journal of cancer

authors： Piqueras M,Navarro S,Cañete A,Castel V,Noguera R

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:The role of tumour-infiltrating inflammation in the prognosis of patients with colorectal cancer (CRC) has not been fully evaluated. The primary objective of our meta-analysis was to determine the impact of tumour-infiltrating inflammation on survival outcomes. METHODS:Ovid MEDLINE and EMBASE were searched ...

journal_title：British journal of cancer

authors： Mei Z,Liu Y,Liu C,Cui A,Liang Z,Wang G,Peng H,Cui L,Li C

更新日期：2014-03-18 00:00:00

abstract：BACKGROUND:Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR), leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR) and CRP/albumin ratio (CRP/Alb) was shown to impact the survival prognosis in patients with extracranial solid cancer. METHO...

journal_title：British journal of cancer

authors： Starzer AM,Steindl A,Mair MJ,Deischinger C,Simonovska A,Widhalm G,Gatterbauer B,Dieckmann K,Heller G,Preusser M,Berghoff AS

更新日期：2021-01-21 00:00:00

abstract：BACKGROUND:The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first y...

journal_title：British journal of cancer

authors： Downing A,Aravani A,Macleod U,Oliver S,Finan PJ,Thomas JD,Quirke P,Wilkinson JR,Morris EJ

更新日期：2013-02-19 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted at low levels by normal luminal epithelial cells of the prostate and in significantly higher levels by prostate cancer cells. Therefore, PSA is a potential target for various immunotherapeutical approaches against prostate cancer. DNA vaccination has been i...

journal_title：British journal of cancer

authors： Pavlenko M,Roos AK,Lundqvist A,Palmborg A,Miller AM,Ozenci V,Bergman B,Egevad L,Hellström M,Kiessling R,Masucci G,Wersäll P,Nilsson S,Pisa P

更新日期：2004-08-16 00:00:00

abstract：:Nerve growth factor (NGF) administration to athymic mice with transplanted human bromocriptine-resistant prolactinoma, results in the expression of dopamine D-2 receptors in the tumour and restores sensitivity to subsequent treatment with bromocriptine, which then produces normalisation of plasma prolactin and tumour ...

journal_title：British journal of cancer

authors： Missale C,Losa M,Boroni F,Giovanelli M,Balsari A,Spano PF

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Elderly cancer patients form a heterogeneous population in which therapeutic decision-making is often difficult. The aim of this randomised phase II trial was to evaluate the feasibility and activity of weekly docetaxel/gemcitabine (DG) followed by erlotinib after progression (arm A) vs erlotinib followed by...

journal_title：British journal of cancer

authors： LeCaer H,Barlesi F,Corre R,Jullian H,Bota S,Falchero L,Vergnenegre A,Dujon C,Delhoume JY,Chouaid C,GFPC 0504 Team.

更新日期：2011-10-11 00:00:00

abstract：:Cancer incidence in the Falkland Islands, 1989-2000, was compared with rates in England and Wales, from which most Islanders originate. Colon and rectum cancer incidence was significantly raised 1989-93 but greatly reduced after 1994, when colonoscopic screening in high-risk families and sigmoidoscopic screening in th...

journal_title：British journal of cancer

authors： Swerdlow AJ,Elsby B,Qiao Z

更新日期：2001-11-02 00:00:00

abstract：:Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...

journal_title：British journal of cancer

authors： Woods LM,Rachet B,Cooper N,Coleman MP

更新日期：2007-04-10 00:00:00

abstract：:Several techniques are under development to diagnose oesophageal adenocarcinoma at an earlier stage. We have demonstrated the potential of Raman spectroscopy, an optical diagnostic technique, for the identification and classification of malignant changes. However, there is no clear recognition of the biochemical chang...

journal_title：British journal of cancer

authors： Shetty G,Kendall C,Shepherd N,Stone N,Barr H

更新日期：2006-05-22 00:00:00

abstract：:In the present multicentre randomized phase II trial, the activity and toxicity of three platinum-based combination regimens for the treatment of advanced non-small-cell lung cancer (NSCLC) were evaluated. The three regimens were: MVP (mitomycin-C 6 mg m(-2) on day 1, vindesine 3 mg m(-2) on days 1 and 15, and cisplat...

journal_title：British journal of cancer

authors： Baldini E,Tibaldi C,Ardizzoni A,Salvati F,Antilli A,Portalone L,Barbera S,Romano F,De Marinis F,Migliorino MR,Noseda MA,Borghini U,Crippa M,Ferrara G,Raimondi M,Fioretti M,Bandera M,Pennucci MC,Galeasso G,Cacciani G

更新日期：1998-06-01 00:00:00

abstract：:T-lymphocyte maturation associated protein, MAL, has been described as a tumour-suppressor gene with diagnostic value in colorectal and oesophageal cancers, and can be inactivated by promoter hypermethylation. The aim of this study was to analyse the prevalence of MAL promoter hypermethylation and the association with...

journal_title：British journal of cancer

authors： Buffart TE,Overmeer RM,Steenbergen RD,Tijssen M,van Grieken NC,Snijders PJ,Grabsch HI,van de Velde CJ,Carvalho B,Meijer GA

更新日期：2008-12-02 00:00:00

abstract：:To: (1) estimate the prevalence of clinically significant emotional distress in patients attending a cancer outpatient department and (2) determine the associations between distress and demographic and clinical variables, we conducted a survey of outpatients attending selected clinics of a regional cancer centre in Ed...

journal_title：British journal of cancer

authors： Strong V,Waters R,Hibberd C,Rush R,Cargill A,Storey D,Walker J,Wall L,Fallon M,Sharpe M

更新日期：2007-03-26 00:00:00

abstract：:Anti-inflammatory corticosteroids administered to rats in high dosages before intravenous injection of allogeneic tumour cells caused 5-10 fold reductions in "take" and clonogenic growth of the cells in lung and kidney and decreased growth and spread of the cells transplanted to leg muscle. Steroid therapy also reduce...

journal_title：British journal of cancer

authors： Van Den Brenk HA,Kelly H,Orton C

更新日期：1974-05-01 00:00:00

abstract：:Survival data on female invasive breast cancer with 9-year follow-up from five French cancer registries were analysed by logistic regression for prognostic factors of cancer stage. The Kaplan-Meier method and log-rank test were used to estimate and compare the overall survival probability at 5 and 7 years, and at the ...

journal_title：British journal of cancer

authors： Gentil-Brevet J,Colonna M,Danzon A,Grosclaude P,Chaplain G,Velten M,Bonnetain F,Arveux P

更新日期：2008-01-15 00:00:00

abstract：BACKGROUND:Only a small proportion of patients respond to anti-VEGF therapy, pressing the need for a reliable biomarker that can identify patients who will benefit. We studied the biological activity of anti-VEGF antibodies in patients' blood during anti-VEGF therapy by using the Ba/F3-VEGFR2 cell line, which is depend...

journal_title：British journal of cancer

authors： Wentink MQ,Broxterman HJ,Lam SW,Boven E,Walraven M,Griffioen AW,Pili R,van der Vliet HJ,de Gruijl TD,Verheul HM

更新日期：2016-10-11 00:00:00

abstract：:The effect of LiCl on melanoma cell growth and differentiation was studied in mouse and human melanoma cell lines. LiCl markedly inhibited B16 and HT-144 melanoma cell growth in vitro. Clonogenicity in soft agar of the melanoma cells was also markedly inhibited by LiCl. Pretreatment of B16 mouse melanoma cells with Li...

journal_title：British journal of cancer

authors： Nordenberg J,Panet C,Wasserman L,Malik Z,Fuchs A,Stenzel KH,Novogrodsky A

更新日期：1987-01-01 00:00:00

abstract：:Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but...

journal_title：British journal of cancer

authors： Rubens RD,Knight RK,Hayward JL

更新日期：1975-12-01 00:00:00

abstract：:The level of expression of keratinocyte growth factor (KGF) mRNA has been measured in human breast cell lines, purified populations of epithelial cells, myoepithelial cells and fibroblasts from reduction mammoplasty tissue and a panel of 42 breast cancers and 30 non-malignant human breast tissues using a semiquantitat...

journal_title：British journal of cancer

authors： Bansal GS,Cox HC,Marsh S,Gomm JJ,Yiangou C,Luqmani Y,Coombes RC,Johnston CL

更新日期：1997-01-01 00:00:00

abstract：:Vascular and angiogenic processes provide an important target for novel cancer therapeutics. Dynamic contrast-enhanced magnetic resonance imaging is being used increasingly to noninvasively monitor the action of these therapeutics in early-stage clinical trials. This publication reports the outcome of a workshop that ...

journal_title：British journal of cancer

authors： Leach MO,Brindle KM,Evelhoch JL,Griffiths JR,Horsman MR,Jackson A,Jayson GC,Judson IR,Knopp MV,Maxwell RJ,McIntyre D,Padhani AR,Price P,Rathbone R,Rustin GJ,Tofts PS,Tozer GM,Vennart W,Waterton JC,Williams SR,Work

更新日期：2005-05-09 00:00:00