Abstract：
:In this study we have screened a series of 29 primary leiomyosarcomas for abnormalities of both the p53 gene and the MDM2 gene, which encodes a p53-associated protein. SSCP (single-strand conformation polymorphism) analysis and direct sequencing of polymerase chain reaction (PCR)-amplified DNA were used to establish that 6/29 tumours possessed point mutations of the p53 gene. Using a monoclonal antibody that recognises the p53 protein in immunohistochemical staining experiments, we observed overexpression of the p53 protein in five of the six tumours containing point mutations in the p53 gene. Southern analysis of tumour DNA revealed that 2/29 tumours demonstrated amplification of the MDM2 gene. When considered together, these results indicate that alterations in both the p53 gene and MDM2 gene are important in the development of a significant minority of leiomyosarcomas. In addition, we have demonstrated a significant association between the presence of abnormalities of the p53 gene or MDM2 genes in leiomyosarcomas and a more advanced clinicopathological stage (P = 0.03). We have also examined the role of the DCC tumour-suppressor gene in the development of human soft-tissue tumours in a variety of histological types. Except for evidence of a rearrangement in a single leiomyosarcoma cell line, SK-UT-1, we have found no direct evidence to support a role for mutation of the gene in the development of human soft-tissue tumours.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Patterson H,Gill S,Fisher C,Law MG,Jayatilake H,Fletcher CD,Thomas M,Grimer R,Gusterson BA,Cooper CSdoi
10.1038/bjc.1994.207subject
Has Abstractpub_date
1994-06-01 00:00:00pages
1052-8issue
6eissn
0007-0920issn
1532-1827journal_volume
69pub_type
杂志文章abstract：BACKGROUND:Diet modulates inflammation and inflammatory markers have been associated with cancer outcomes. In the Women's Health Initiative, we investigated associations between a dietary inflammatory index (DII) and invasive breast cancer incidence and death. METHODS:The DII was calculated from a baseline food freque...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.98
更新日期：2016-05-24 00:00:00
abstract：:We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 we...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603893
更新日期：2007-09-03 00:00:00
abstract：:Recombinant single-chain fragments (scFv) of the murine anti-MUC1 monoclonal antibody C595 have been produced using the original hybridoma cells as a source of variable heavy (V(H))- and variable light (V(L))-chain-encoding antibody genes. The use of the polymerase chain reaction (PCR), bacteriophage (phage) display t...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.434
更新日期：1997-01-01 00:00:00
abstract：:We have investigated dihydropyrimidine dehydrogenase expression as a prognostic marker in breast cancer. A total of 119 women with breast cancer undergoing surgery between 1985 and 1996 were included in this study. Eighty-seven patients were treated with postoperative chemotherapy including 5-fluorouracil or 5-fluorou...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6600040
更新日期：2002-01-21 00:00:00
abstract：BACKGROUND:Cabazitaxel is approved for treatment of castration-resistant metastatic prostate cancer. The current dosing strategy of cabazitaxel is based on body surface area (BSA). Body surface area is known as a poor predictor for total systemic exposure to drugs, since it does not take into account variability in act...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.91
更新日期：2017-05-09 00:00:00
abstract：:Initial studies revealed that proline-directed protein kinase F(A) (PDPK F(A)) was overexpressed in various cancerous tissues relative to normal controls. However, the functional role of overexpressed PDPK F(A) in cancer remains to be established. In this report, we explore the potential role of PDPK F(A) in leukaemia...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1054/bjoc.1999.1133
更新日期：2000-04-01 00:00:00
abstract：BACKGROUND:Locally advanced oesophageal cancer (LAEC) is associated with poor survival and more effective treatments are needed. The aim of this phase I trial was to assess the maximum tolerated dose (MTD) of a novel weekly docetaxel and cisplatin regimen concurrent with radical radiotherapy. METHODS:Patients with unr...
journal_title：British journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1038/sj.bjc.6606051
更新日期：2011-01-18 00:00:00
abstract：:2-Amino-3,4-dihydro-6-methyl-4-oxo-5-(4-pyridylthio)-quinazoline dihydrochloride (nolatrexed dihydrochloride, Thymitaq, AG337), a specific inhibitor of thymidylate synthase, was developed using protein structure-based drug design. Intravenously administered nolatrexed is active clinically. As oral bioavailability is h...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1038/sj.bjc.6690146
更新日期：1999-02-01 00:00:00
abstract：BACKGROUND:Transarterial chemo-embolisation (TACE) is recommended for patients with BCLC intermediate stage hepatocellular carcinoma (stage B), particularly in patients with good underlying liver function and minimal symptoms. The hepatoma arterial embolisation prognostic (HAP) score combines measures of liver function...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2016.423
更新日期：2017-02-14 00:00:00
abstract：:An analysis of the occurrence of breast cancer in this long-term prospective cohort study shows a significant relative risk (RR) in women who have ever used oral contraceptives (OC) of 3.33 in women age 30 to 34 years at diagnosis and an RR of 5.88 (P = 0.0011) in women who were parity 1 at the time of diagnosis. In w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1988.285
更新日期：1988-11-01 00:00:00
abstract：:A phase I study of the bispecific antibody MDX-H210 in combination with granulocyte colony-stimulating factor (G-CSF) was performed in stage IV breast carcinoma patients, overexpressing HER-2/neu. MDX-H210, constructed by crosslinking antigen binding fragments (F(ab') fragments) of monoclonal antibody (mAb) H22 to Fc ...
journal_title：British journal of cancer
pub_type： 临床试验,杂志文章
doi：10.1038/sj.bjc.6601367
更新日期：2003-12-15 00:00:00
abstract：BACKGROUND:The National Comprehensive Cancer Network (NCCN) guidelines provide recommendations for staging of prostate cancer patients in the objective regarding presence of locoregional lymph node metastases (LNM) and bone metastases. We tested the performance characteristics of these recommendations in a community se...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-018-0323-3
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2012.410
更新日期：2012-10-09 00:00:00
abstract：BACKGROUND:Immune checkpoint blockade (ICB) therapy improved the prognosis of cancer patients, but general administration of ICBs occasionally induces side effects that include immune-related adverse events and tumour hyper-progression. Here, we established a protein-based system, by which endogenous expression of IC m...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-019-0708-y
更新日期：2020-03-01 00:00:00
abstract：:Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies u...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1994.402
更新日期：1994-11-01 00:00:00
abstract：:With few exceptions, the major limit to high-dose chemotherapeutic treatments is the severity and duration of drug-induced myelosuppression. We have recently developed a monoclonal antibody, MAD11, which reacts with the potent anti-tumour antibiotic doxorubicin and other anthracyclines. To protect directly pluripotent...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.117
更新日期：1997-01-01 00:00:00
abstract：:In the UK, 10% of patients diagnosed with rectal cancer have inoperable disease at presentation. This study ascertained whether the resectability rate of inoperable locally advanced rectal cancer was improved by administration of intravenous irinotecan, 5-fluorouracil (5-FU) and pelvic radiotherapy. During phase I of ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6604292
更新日期：2008-04-08 00:00:00
abstract：BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.137
更新日期：2014-04-29 00:00:00
abstract：:In the present study we demonstrate that Aza-dC in combination with Amsacrine has major antileukaemic properties in patients who have not already received extensive Ara-C therapy. Eight out of 11 patients in their first relapse of acute leukaemia achieved complete remission. Cross resistance between Ara-C and Aza-dC w...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1991.258
更新日期：1991-07-01 00:00:00
abstract：:In vivo models of acquired resistance to the platinum-based agents cisplatin (CDDP), carboplatin (CBDCA), iproplatin (CHIP) and tetraplatin have been established using a panel of six parent human ovarian carcinoma lines, two (HX/110 and PXN/87) being derived from previously untreated patients. Resistance has been gene...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1993.5
更新日期：1993-01-01 00:00:00
abstract：:Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and th...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6602420
更新日期：2005-03-14 00:00:00
abstract：:Both biodegradable emboli and pharmacological agents can enhance regional therapy for hepatic targeting. Using a rat model with similar haemodynamic characteristics to human colorectal liver tumour and a radio-labelled marker of similar molecular weight to Adriamycin, we have combined the two approaches to see if the ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1992.7
更新日期：1992-01-01 00:00:00
abstract：:Immunofluorescent assessment of hormone receptors in melanocytic tumours is quite feasible without loss of diagnostic material, in contrast to the impracticability of quantitative biochemical assays. Using this method, oestrogen receptors were demonstrated in 4/6, and progesterone receptors in 3/5 patients with metast...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1981.95
更新日期：1981-05-01 00:00:00
abstract：:Fifty-one patients with advanced non-small cell lung carcinoma were treated with a combination of mitomycin C, vinblastine and cis-platin (MVP). Most cycles were given on an out-patient basis. Major side effects were leukopenia and peripheral neurotoxicity; one patient died of sepsis while leukopenic. In 44 evaluable ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1987.227
更新日期：1987-10-01 00:00:00
abstract：:The GER human pancreatic carcinoma cell line possesses receptors for 1,25-dihydroxyvitamin D3. We report that the vitamin D analogue EB 1089 inhibits the growth of these cells in vitro and when grown as tumour xenografts in immunodeficient mice. Tumour-bearing mice were given EB 1089 at a dose of 5 microg kg(-1) body ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.1997.501
更新日期：1997-01-01 00:00:00
abstract：:P-glycoprotein (P-gp) pumps multiple types of drugs out of the cell, using energy generated from ATP, and confers multidrug resistance (MDR) on cancer cells. ZD6474 is an orally active, selective inhibitor of the vascular endothelial growth factor receptor, epidermal growth factor receptor, and rearranged during trans...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6603985
更新日期：2007-10-08 00:00:00
abstract：BACKGROUND:There is growing evidence that spleen tyrosine kinase (SYK) is critical for acute myeloid leukaemia (AML) transformation and maintenance of the leukemic clone in AML patients. It has also been found to be over-expressed in AML patients, with activating mutations in foetal liver tyrosine kinase 3 (FLT3), part...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/s41416-020-0731-z
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated wi...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2014.201
更新日期：2014-05-13 00:00:00
abstract：:HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/sj.bjc.6605084
更新日期：2009-06-16 00:00:00
abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...
journal_title：British journal of cancer
pub_type： 杂志文章
doi：10.1038/bjc.2017.494
更新日期：2018-03-20 00:00:00
