当前位置： SCI文献检索 > BRITISH JOURNAL OF CANCER期刊下所有文献 > Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.

Aldehyde dehydrogenase 3A1 associates with prostate tumorigenesis.

Abstract：

BACKGROUND:Accumulating evidence demonstrates high levels of aldehyde dehydrogense (ALDH) activity in human cancer types, in part, because of its association with cancer stem cells. Whereas ALDH1A1 and ALDH7A1 isoforms were reported to associate with prostate tumorigenesis, whether other ALDH isoforms are associated with prostate cancer (PC) remains unclear. METHODS:ALDH3A1 expression was analysed in various PC cell lines. Xenograft tumours and 54 primary and metastatic PC tumours were stained using immunohistochemistry for ALDH3A1 expression. RESULTS:In comparison with the non-stem counterparts, a robust upregulation of ALDH3A1 was observed in DU145-derived PC stem cells (PCSCs). As DU145 PCSCs produced xenograft tumours with more advanced features compared with those derived from DU145 cells, higher levels of ALDH3A1 were detected in the former; a dramatic elevation of ALDH3A1 occurred in DU145 cell-derived lung metastasis compared with local xenograft tumours. Furthermore, while ALDH3A1 was not observed in prostate glands, ALDH3A1 was clearly present in PIN, and further increased in carcinomas. In comparison with the paired local carcinomas, ALDH3A1 was upregulated in lymph node metastatic tumours; the presence of ALDH3A1 in bone metastatic PC was also demonstrated. CONCLUSIONS:We report here the association of ALDH3A1 with PC progression.

journal_name

Br J Cancer

journal_title

British journal of cancer

authors

Yan J,De Melo J,Cutz JC,Aziz T,Tang D

doi

10.1038/bjc.2014.201

subject

Has Abstract

pub_date

2014-05-13 00:00:00

pages

2593-603

issue

10

eissn

0007-0920

issn

1532-1827

pii

bjc2014201

journal_volume

110

pub_type

杂志文章

相关文献

BRITISH JOURNAL OF CANCER文献大全
  • Histology in breast cancer prognosis.

    abstract：:Histological sections of the primary tumour and of homolateral axillary lymph nodes from 500 women with operable invasive breast cancer have been examined. The tumours have been graded and the degree of round cell infiltration assessed. These features, together with clinical palpability and pathological involvement of...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1972.19

    authors： Champion HR,Wallace IW,Prescott RJ

    更新日期：1972-04-01 00:00:00

  • Correlation between cancer mortality and alcoholic beverage in Japan.

    abstract：:Geographical correlations between standardized, mortality ratios (SMRs) of cancers and consumption of different types of alcoholic beverages (saké synthetic saké, shochu, beer, wine, and whisky), of cigarettes, and urbanization were examined for all 46 prefectures in Japan. Suggestive correlations were observed betwee...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1979.200

    authors： Kono S,Ikeda M

    更新日期：1979-09-01 00:00:00

  • Lack of Bcl10 mutations in testicular germ cell tumours and derived cell lines.

    abstract：:Aberrations within Bcl10, a gene involved in execution of apoptosis, has most recently been found in a variety of cancers, including cell lines of testicular germ cell tumours of adolescents and adults (TGCTs). To study this in more detail, we screened exons 2 and 3 of this gene for mutations in a larger series of cel...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6690563

    authors： van Schothorst EM,Mohkamsing S,van Gurp RJ,Oosterhuis JW,van der Saag PT,Looijenga LH

    更新日期：1999-07-01 00:00:00

  • Sexual quality of life in Hodgkin Lymphoma: a longitudinal analysis by the German Hodgkin Study Group.

    abstract：BACKGROUND:Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. METHODS:Four-thousand one-hundred and sixty patients enroled in the HD10-HD12 trials underwent HRQoL assessme...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2012.550

    authors： Behringer K,Müller H,Görgen H,Flechtner HH,Brillant C,Halbsguth TV,Thielen I,Eichenauer DA,Schober T,Nisters-Backes H,Fuchs M,Engert A,Borchmann P

    更新日期：2013-01-15 00:00:00

  • Expression of the multidrug resistance-associated protein (MRP) gene in non-small-cell lung cancer.

    abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.372

    authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

    更新日期：1995-09-01 00:00:00

  • Mutant, wild type, or overall p53 expression: freedom from clinical progression in tumours of astrocytic lineage.

    abstract：:Abnormalities of the p53 tumor-suppressor gene are found in a significant proportion of astrocytic brain tumours. We studied tumour specimens from 74 patients evaluated over 20 years at the Massachusetts General Hospital, where clinical outcome could be determined and sufficient pathologic material was available for i...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602161

    authors： Pardo FS,Hsu DW,Zeheb R,Efird JT,Okunieff PG,Malkin DM

    更新日期：2004-11-01 00:00:00

  • Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2-· production in cancer cells.

    abstract：BACKGROUND:The TP53 tumor suppressor gene is the most frequently altered gene in tumors and mutant p53 gain-of-function isoforms actively promote cancer malignancy. METHODS:A panel of wild-type and mutant p53 cancer cell lines of different tissues, including pancreas, breast, skin, and lung were used, as well as chron...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/s41416-018-0288-2

    authors： Cordani M,Butera G,Dando I,Torrens-Mas M,Butturini E,Pacchiana R,Oppici E,Cavallini C,Gasperini S,Tamassia N,Nadal-Serrano M,Coan M,Rossi D,Gaidano G,Caraglia M,Mariotto S,Spizzo R,Roca P,Oliver J,Scupoli MT,Donad

    更新日期：2018-10-01 00:00:00

  • Expression of DNA damage response proteins and complete remission after radiotherapy of stage IB-IIA of cervical cancer.

    abstract：:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603153

    authors： Beskow C,Kanter L,Holgersson A,Nilsson B,Frankendal B,Avall-Lundqvist E,Lewensohn R

    更新日期：2006-06-05 00:00:00

  • Genetic and epigenetic analyses of MBD3 in colon and lung cancer.

    abstract：:MBD3: is a member of the methyl-CpG-binding domain family and is located on chromosome 19p13.3, a region of loss of heterozygosity in colon and lung cancers. We therefore screened samples for abnormalities in MBD3. Our results indicate that MBD3 is not a major target of genetic and epigenetic alteration in these cance...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6601776

    authors： Zhu Y,Harrison DJ,Bader SA

    更新日期：2004-05-17 00:00:00

  • The effects of 6-mercaptopurine nucleotide derivatives on the growth and survival of 6-mercaptopurine-sensitive and -resistant cell culture lines.

    abstract：:6-Mercaptopurine (MP)-sensitive and -resistant cell culture lines were used to further characterize the apparent ability of MP nucleotide derivatives to overcome resistance to the parent drug. 6-Mercaptopurine-9-beta-D-ribofuranoside 5'-monophosphate [MPRP], bis(6-mercaptopurine-9-beta-D-ribofuranoside)-5', 5"'-monoph...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.73

    authors： Johnston HP,Hawley P,White SE,Gibson I,Tidd DM

    更新日期：1985-04-01 00:00:00

  • Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients.

    abstract：:The abilities of chemokines in orchestrating cellular migration are utilised by different (patho-)biological networks including malignancies. However, except for CXCR4/CXCL12, little is known about the relation between tumour-related chemokine expression and the development and progression of solid tumours like breast...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604621

    authors： Panse J,Friedrichs K,Marx A,Hildebrandt Y,Luetkens T,Barrels K,Horn C,Stahl T,Cao Y,Milde-Langosch K,Niendorf A,Kröger N,Wenzel S,Leuwer R,Bokemeyer C,Hegewisch-Becker S,Atanackovic D

    更新日期：2008-09-16 00:00:00

  • Comparison of 1- and 2-year screening intervals for women undergoing screening mammography.

    abstract：:We compared the long-term impact of 1- and 2-year screening mammography intervals using prognostic, screening, and outcome information for women aged 50-74 years obtained from the Screening Mammography Program of British Columbia in two time periods, prior to 1997 (policy of annual mammography) and after 1997 (biennia...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602393

    authors： Wai ES,D'yachkova Y,Olivotto IA,Tyldesley S,Phillips N,Warren LJ,Coldman AJ

    更新日期：2005-03-14 00:00:00

  • Cross-reactivity between Candida albicans and human ovarian carcinoma as revealed by monoclonal antibodies PA10F and C6.

    abstract：:Summary Antibodies against Candida albicans antigenic determinants have been reported to cross-react with human tumour cells. We have found that two monoclonal antibodies, C6 and PA1OF, developed at our laboratory against C. albicans antigenic determinants, cross-react with human ovarian cancer on Western blots and im...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1998.167

    authors： Schneider J,Moragues D,Martínez N,Romero H,Jimenez E,Pontón J

    更新日期：1998-03-01 00:00:00

  • A tumour-associated cell-surface glycoprotein accompanying p53 overexpression and higher growth potential for gastric cancer.

    abstract：:Tumour-associated cell-surface glycoprotein is associated with tumour progression in gastric cancer. We investigated the biological significance of tumour-associated cell-surface glycoprotein, determined by the binding of Helix pomatia agglutinin (HPA), with regard to survival time and to the malignant potential of ca...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1995.192

    authors： Maehara Y,Okuyama T,Kakeji Y,Endo K,Yamamoto M,Sugimachi K

    更新日期：1995-05-01 00:00:00

  • A case-control study of head and neck cancer in the Republic of Ireland.

    abstract：:A retrospective case-control study of 200 patients with head and neck cancer, and 200 controls matched for age and sex, confirmed the importance of tobacco and alcohol consumption in the aetiology of malignant tumours of the upper gastrointestinal and upper respiratory tracts. A male-female ratio of 3:1 was found, and...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1981.26

    authors： Herity B,Moriarty M,Bourke GJ,Daly L

    更新日期：1981-02-01 00:00:00

  • Protection of mice against cancer by immunization with membranes but not purified virions from virus infected cancer cells.

    abstract：:The life span of C57/Bl mice inoculated with Lewis lung carcinoma cells was prolonged if the mice were pre-immunized with membranes from these cells infected in vitro with influenza virus. Likewise, BALB/c mice were protected against the malignant tumour WEHI-11 by prior immunization with extracts of cultured WEHI-11 ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1975.106

    authors： Griffith IP,Crook NE,White DO

    更新日期：1975-06-01 00:00:00

  • Definition of the role of chromosome 9p21 in sporadic melanoma through genetic analysis of primary tumours and their metastases. The Melanoma Cooperative Group.

    abstract：:Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1054/bjoc.2000.1513

    authors： Palmieri G,Cossu A,Ascierto PA,Botti G,Strazzullo M,Lissia A,Colombino M,Casula M,Floris C,Tanda F,Pirastu M,Castello G,Melanoma Cooperative Group.

    更新日期：2000-12-01 00:00:00

  • Aerosolised 5-azacytidine suppresses tumour growth and reprogrammes the epigenome in an orthotopic lung cancer model.

    abstract：BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2013.575

    authors： Reed MD,Tellez CS,Grimes MJ,Picchi MA,Tessema M,Cheng YS,March TH,Kuehl PJ,Belinsky SA

    更新日期：2013-10-01 00:00:00

  • Breast density and outcome of mammography screening: a cohort study.

    abstract：:The purpose of this study was to investigate the effect of breast density on breast cancer (BC) mortality in a mammography screening programme. The cohort included 48 052 women participating in mammography screening in Copenhagen, Denmark, where biennial screening is offered to women aged 50-69 years. We collected inf...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6604989

    authors： Olsen AH,Bihrmann K,Jensen MB,Vejborg I,Lynge E

    更新日期：2009-04-07 00:00:00

  • Activation and activities of the p53 tumour suppressor protein.

    abstract：:The p53 tumour suppressor protein inhibits malignant progression by mediating cell cycle arrest, apoptosis or repair following cellular stress. One of the major regulators of p53 function is the MDM2 protein, and multiple forms of cellular stress activate p53 by inhibiting the MDM2-mediated degradation of p53. Mutatio...

    journal_title：British journal of cancer

    pub_type： 杂志文章,评审

    doi：10.1054/bjoc.2001.2128

    authors： Bálint E E,Vousden KH

    更新日期：2001-12-14 00:00:00

  • A multicenter phase 1 study of PX-866 in combination with docetaxel in patients with advanced solid tumours.

    abstract：BACKGROUND:This phase I, dose-finding study determined the safety, maximum tolerated dose (MTD)/recommended phase 2 dose (RP2D), pharmacokinetics, and antitumour activity of PX-866, a phosphatidylinositol 3-kinase inhibitor, combined with docetaxel in patients with incurable solid tumours. METHODS:PX-866 was administe...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1038/bjc.2013.474

    authors： Bowles DW,Ma WW,Senzer N,Brahmer JR,Adjei AA,Davies M,Lazar AJ,Vo A,Peterson S,Walker L,Hausman D,Rudin CM,Jimeno A

    更新日期：2013-09-03 00:00:00

  • High-dose intensity cyclophosphamide, epidoxorubicin, vincristine and prednisone by shortened intervals and granulocyte colony-stimulating factor in non-Hodgkin's lymphoma: a phase II study.

    abstract：:Twenty patients with non-Hodgkin's lymphoma were treated with a combination of cyclophosphamide (750 mg m(-2), day 1), epidoxorubicin (60 mg m(-2), day 1), vincristine (1.4 mg m(-2), day 1) and prednisone (100 mg m(-2), days 1-5) every 14 days. Shortening of intervals was associated with the prophylactic employment of...

    journal_title：British journal of cancer

    pub_type： 临床试验,杂志文章

    doi：10.1038/bjc.1998.578

    authors： Pronzato P,Lionetto R,Botto F,Pensa F,Tognoni A

    更新日期：1998-09-01 00:00:00

  • Expression and mutation analysis of the discoidin domain receptors 1 and 2 in non-small cell lung carcinoma.

    abstract：:The discoidin domain receptors, (DDR)1 and DDR2, have been linked to numerous human cancers. We sought to determine expression levels of DDRs in human lung cancer, investigate prognostic determinates, and determine the prevalence of recently reported mutations in these receptor tyrosine kinases. Tumour samples from 14...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6603614

    authors： Ford CE,Lau SK,Zhu CQ,Andersson T,Tsao MS,Vogel WF

    更新日期：2007-03-12 00:00:00

  • Health-related quality of life impact of cobimetinib in combination with vemurafenib in patients with advanced or metastatic BRAFV600 mutation-positive melanoma.

    abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

    journal_title：British journal of cancer

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1038/bjc.2017.488

    authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

    更新日期：2018-03-20 00:00:00

  • Enhancement of transforming growth factor-alpha synthesis in multicellular tumour spheroids of A431 squamous carcinoma cells.

    abstract：:Multicellular tumour spheroids are cellular aggregates that can be prepared from many types of tumour cells. These three-dimensional structures provide a model for analysing the effects of cell-cell contact and intercellular microenvironments on phenomena such as autocrine regulation of growth factor synthesis. Autore...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1992.34

    authors： Laderoute KR,Murphy BJ,Short SM,Grant TD,Knapp AM,Sutherland RM

    更新日期：1992-02-01 00:00:00

  • Goserelin (Zoladex) in premenopausal advanced breast cancer: duration of response and survival.

    abstract：:In premenopausal women with advanced breast cancer the luteinising hormone-releasing hormone agonist goserelin (Zoladex, ICI plc) will produce serum levels of oestradiol equivalent to those following surgical oophorectomy or the menopause. This paper reports our further experience of using this drug in 75 premenopausa...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1990.397

    authors： Dixon AR,Robertson JF,Jackson L,Nicholson RI,Walker KJ,Blamey RW

    更新日期：1990-11-01 00:00:00

  • A phase I pharmacokinetic study of the vascular disrupting agent ombrabulin (AVE8062) and docetaxel in advanced solid tumours.

    abstract：BACKGROUND:The vascular disrupting agent ombrabulin shows synergy with docetaxel in vivo. Recommended phase II doses were determined in a dose escalation study in advanced solid tumours. METHODS:Ombrabulin (30-min infusion, day 1) followed by docetaxel (1-h infusion, day 2) every 3 weeks was explored. Ombrabulin was e...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2014.137

    authors： Eskens FA,Tresca P,Tosi D,Van Doorn L,Fontaine H,Van der Gaast A,Veyrat-Follet C,Oprea C,Hospitel M,Dieras V

    更新日期：2014-04-29 00:00:00

  • Expression of oncofoetal pancreatic antigens in hamster adult pancreas during experimental carcinogenesis.

    abstract：:Foetal acinar components associated with the development of the hamster pancreas have been previously defined with the aid of an antifoetal pancreas serum. In immunohistology this antiserum also stained malignant ductal cells in N-nitrobis (2-oxopropyl) amine (BOP)-induced pancreatic adenocarcinoma. It did not stain a...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.1985.28

    authors： Escribano MJ,Carré-Llopis A,Loridon-Rosa B

    更新日期：1985-02-01 00:00:00

  • Phase II study of gemcitabine and cisplatin in locally advanced/metastatic oesophageal cancer.

    abstract：:Palliative chemotherapy for inoperable/metastatic oesophageal cancer has limited activity. This study assesses the feasibility and activity of gemcitabine and cisplatin in this group of patients. In total, 42 patients with locally advanced/metastatic squamous or adenocarcinoma of the oesophagus were treated with gemci...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/sj.bjc.6602842

    authors： Millar J,Scullin P,Morrison A,McClory B,Wall L,Cameron D,Philips H,Price A,Dunlop D,Eatock M

    更新日期：2005-11-14 00:00:00

  • Survival gains needed to offset persistent adverse treatment effects in localised prostate cancer.

    abstract：BACKGROUND:Men diagnosed with localised prostate cancer (LPC) face difficult choices between treatment options that can cause persistent problems with sexual, urinary and bowel function. Controlled trial evidence about the survival benefits of the full range of treatment alternatives is limited, and patients' views on ...

    journal_title：British journal of cancer

    pub_type： 杂志文章

    doi：10.1038/bjc.2011.552

    authors： King MT,Viney R,Smith DP,Hossain I,Street D,Savage E,Fowler S,Berry MP,Stockler M,Cozzi P,Stricker P,Ward J,Armstrong BK

    更新日期：2012-02-14 00:00:00