A case-control study of head and neck cancer in the Republic of Ireland.

abstract：BACKGROUND:This study was aimed to develop a new method for personalising chemotherapeutic and granulocyte colony-stimulating factor (G-CSF) combined schedules, and use it for suggesting efficacious chemotherapy with reduced neutropenia. METHODS:Clinical data from 38 docetaxel (Doc)-treated metastatic breast cancer pa...

journal_title：British journal of cancer

authors： Vainas O,Ariad S,Amir O,Mermershtain W,Vainstein V,Kleiman M,Inbar O,Ben-Av R,Mukherjee A,Chan S,Agur Z

更新日期：2012-08-21 00:00:00

abstract：:It has been suggested that tamoxifen may improve the efficacy of medical castration with luteinising hormone-releasing hormone analogues, but very few data have so far been published concerning the clinical and endocrinological activity of this therapeutic modality. In this phase II multicentre trial conducted by the ...

journal_title：British journal of cancer

authors： Buzzoni R,Biganzoli L,Bajetta E,Celio L,Fornasiero A,Mariani L,Zilembo N,Di Bartolomeo M,Di Leo A,Arcangeli G

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:In neuroblastoma (NB), the most powerful prognostic marker, the MYCN amplification (MNA), occasionally shows intratumoural heterogeneity (ITH), i.e. coexistence of MYCN-amplified and non-MYCN-amplified tumour cell clones, called heterogeneous MNA (hetMNA). Prognostication and therapy allocation are still uns...

journal_title：British journal of cancer

authors： Berbegall AP,Bogen D,Pötschger U,Beiske K,Bown N,Combaret V,Defferrari R,Jeison M,Mazzocco K,Varesio L,Vicha A,Ash S,Castel V,Coze C,Ladenstein R,Owens C,Papadakis V,Ruud E,Amann G,Sementa AR,Navarro S,Ambros PF

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND:Recent studies suggest that older patients in the United Kingdom are not benefiting as much from improvements in cancer treatments as their younger counterparts. We investigate whether this might be partly due to differential referral rates using ovarian cancer as an example. METHODS:From the General Practi...

journal_title：British journal of cancer

authors： Tate AR,Nicholson A,Cassell JA

更新日期：2010-03-16 00:00:00

abstract：:The aim of the study was to investigate the association of physician communication behaviours as perceived by the patient with patient reported satisfaction, distress, cancer-related self-efficacy, and perceived control over the disease in cancer patients. Questionnaires measuring distress, self-efficacy, and perceive...

journal_title：British journal of cancer

authors： Zachariae R,Pedersen CG,Jensen AB,Ehrnrooth E,Rossen PB,von der Maase H

更新日期：2003-03-10 00:00:00

abstract：BACKGROUND:The co-chaperone protein Bcl-2-associated athanogene-1 (BAG-1) is overexpressed in breast cancer and has been incorporated in the oncotype DX and PAM50 breast cancer prognostic assays. Bcl-2-associated athanogene-1 exists as multiple protein isoforms that interact with diverse partners, including chaperones ...

journal_title：British journal of cancer

authors： Papadakis ES,Reeves T,Robson NH,Maishman T,Packham G,Cutress RI

更新日期：2017-06-06 00:00:00

abstract：BACKGROUND:Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks as...

journal_title：British journal of cancer

authors： Krestinina LY,Davis FG,Schonfeld S,Preston DL,Degteva M,Epifanova S,Akleyev AV

更新日期：2013-11-26 00:00:00

abstract：:The response of a transplantable rat fibrosarcoma, RIB(5), to a single injection of 100 mg/kg body weight of cyclophosphamide, 0·5, 1, 2 and 3 days after treatment, has been studied by means of a morphometric analysis of tumour sections and has been compared to the changes occurring in untreated tumours. The results s...

journal_title：British journal of cancer

authors： Peel S,Cowen DM

更新日期：1973-01-01 00:00:00

abstract：:This article was originally published under a standard license to Publish, but has now been made available under a CC BY license. The PDF and HTML versions of the paper have been modified accordingly.An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：British journal of cancer

authors： Evans TRJ,Kudo M,Finn RS,Han KH,Cheng AL,Ikeda M,Kraljevic S,Ren M,Dutcus CE,Piscaglia F,Sung MW

更新日期：2019-10-01 00:00:00

abstract：:The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. A...

journal_title：British journal of cancer

authors： Yamada Y,Hamaguchi T,Goto M,Muro K,Matsumura Y,Shimada Y,Shirao K,Nagayama S

更新日期：2003-09-01 00:00:00

abstract：:Using the breast carcinoma cell line MDA-MB 468 as immunogen, we have produced six new rat monoclonal antibodies (mAbs) against the human EGF receptor (EGFR) and are investigating their use for diagnostic and therapeutic applications in cancer patients whose tumours overexpress these receptors. The mAbs (three IgG2b a...

journal_title：British journal of cancer

authors： Modjtahedi H,Styles JM,Dean CJ

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Aberrant choline metabolism has been proposed as a novel cancer hallmark. We recently showed that epithelial ovarian cancer (EOC) possesses an altered MRS-choline profile, characterised by increased phosphocholine (PCho) content to which mainly contribute over-expression and activation of choline kinase-alph...

journal_title：British journal of cancer

authors： Granata A,Nicoletti R,Tinaglia V,De Cecco L,Pisanu ME,Ricci A,Podo F,Canevari S,Iorio E,Bagnoli M,Mezzanzanica D

更新日期：2014-01-21 00:00:00

abstract：:In vivo growth characteristics of myeloid leukaemia induced by whole-body irradiation of CBA/H male mice were examined in the strain of origin by procedures expected to enhance or depress immunological responses. Syngeneic growth in vivo (survival time and frequency of takes) was not modified by attempted active immun...

journal_title：British journal of cancer

authors： Meldrum RA,Mole RH

更新日期：1982-03-01 00:00:00

abstract：:The radiosensitizing activity of S-nitroso-N-acetylpenicillamine (SNAP), a nitric oxide (NO) donor, was assessed in a model of non-metabolic hypoxia achieved in an atmosphere of 95% nitrogen-5% carbon dioxide. A 10 min preincubation of hypoxic EMT-6 cells (10 x 10(6) ml(-1)) with 0.1 and 1 mM SNAP before radiation res...

journal_title：British journal of cancer

authors： Janssens MY,Verovski VN,Van den Berge DL,Monsaert C,Storme GA

更新日期：1999-03-01 00:00:00

abstract：:Axillary lymph nodes draining mammary carcinoma showed an alteration of both micro-architectue and lymphocyte subpopulations. Lymph nodes with a normal or increased T and/or B lymphocyte compartment (assessed by histology) had a low incidence of nodal tumour spread, whilst hypocellularity of the T- or B-lymphocyte-dep...

journal_title：British journal of cancer

authors： Eremin O,Roberts P,Plumb D,Stephens JP

更新日期：1980-01-01 00:00:00

abstract：:Although cancer of the cervix is traditionally considered not to be responsive to steroid hormones, an in vitro study has reported that the addition of oestrogen increased cellular proliferation in a cervix cancer cell line that was inhibited by progesterone. We investigated whether the reported in vitro effects of oe...

journal_title：British journal of cancer

authors： Bhattacharya D,Redkar A,Mittra I,Sutaria U,MacRae KD

更新日期：1997-01-01 00:00:00

abstract：:To evaluate the predictive value of a panel of gene polymorphisms involved in metabolism of 5-FU and cisplatin on clinical outcome in advanced gastric cancer patients. A total of 52 patients were enrolled in this study. DNA was extracted from paraffin-embedded tumour specimen. Genotypes were determined using PCR-RFLP....

journal_title：British journal of cancer

authors： Goekkurt E,Hoehn S,Wolschke C,Wittmer C,Stueber C,Hossfeld DK,Stoehlmacher J

更新日期：2006-01-30 00:00:00

abstract：:Oxygen is an essential regulator of cellular metabolism, survival, and proliferation. Cellular responses to oxygen levels are monitored, in part, by the transcriptional activity of the hypoxia inducible factors (HIFs). Under hypoxia, HIFs regulate a variety of pro-angiogenic and pro-glycolysis pathways. In solid cance...

journal_title：British journal of cancer

authors： Heddleston JM,Li Z,Lathia JD,Bao S,Hjelmeland AB,Rich JN

更新日期：2010-03-02 00:00:00

abstract：:Local recurrence of glioblastomas is a major cause of patient mortality after definitive treatment. This review discusses the roles of the chemokine stromal cell-derived factor-1 and its receptor CXC chemokine receptor 4 (CXCR4) in affecting the sensitivity of glioblastomas to irradiation. Blocking these molecules pre...

journal_title：British journal of cancer

authors： Tseng D,Vasquez-Medrano DA,Brown JM

更新日期：2011-06-07 00:00:00

abstract：BACKGROUND:While current chemotherapy has increased cure rates for children with acute lymphoblastic leukaemia (ALL), the largest number of relapsing patients are still stratified as medium risk (MR) at diagnosis (50-60%). This highlights an opportunity to develop improved relapse-prediction models for MR patients. We ...

journal_title：British journal of cancer

authors： Alruwetei AM,Bendak K,Yadav BD,Carol H,Evans K,Mayoh C,Sutton R,Marshall GM,Lock RB

更新日期：2020-09-01 00:00:00

abstract：:Throughout the world there are problems recruiting ethnic minority patients into cancer clinical trials. A major barrier to trial entry may be distrust of research and the medical system. This may be compounded by the regulatory framework governing research with an emphasis on written consent, closed questions and con...

journal_title：British journal of cancer

authors： Symonds RP,Lord K,Mitchell AJ,Raghavan D

更新日期：2012-09-25 00:00:00

abstract：:Within a population-based cohort study, 40,708 men aged 45-79 years followed from 1998 to 2004. After adjusting for potential confounders, we observed a strong inverse linear association between total daily physical activity (PA) and death from cancer (n=1153). For each increment of 4 metabolic equivalent (MET)-h day(...

journal_title：British journal of cancer

authors： Orsini N,Mantzoros CS,Wolk A

更新日期：2008-06-03 00:00:00

abstract：:The aim of our analysis was to assess retrospectively the effect on local relapse, overall survival (OS) and disease-free survival (DFS) of a limited or an extended lymphadenectomy in radically resected gastric cancer patients. This study was performed in order to identify a subgroup of patients possibly not benefitin...

journal_title：British journal of cancer

authors： Scartozzi M,Galizia E,Graziano F,Catalano V,Berardi R,Baldelli AM,Testa E,Mari D,Silva RR,Cascinu S

更新日期：2005-03-28 00:00:00

abstract：BACKGROUND:A phase Ib study of binimetinib and capecitabine for gemcitabine-pretreated biliary tract cancer (BTC) patients was conducted. METHODS:Binimetinib and capecitabine were dosed twice daily on days 1-14, in 3-week cycles. In the dose-escalation (DE) part, three dose levels (DL) were tested (DL1: binimetinib/ca...

journal_title：British journal of cancer

authors： Kim JW,Lee KH,Kim JW,Suh KJ,Nam AR,Bang JH,Bang YJ,Oh DY

更新日期：2019-08-01 00:00:00

abstract：:We identified 2384 patients in the Danish Cancer Register in whom cancer had been diagnosed in 1960-1996 before they reached the age of 20 and compared them with 53 143 sex- and age-matched controls identified from the Register of Population Statistics. Complete education records and demographic and socioeconomic info...

journal_title：British journal of cancer

authors： Koch SV,Kejs AM,Engholm G,Johansen C,Schmiegelow K

更新日期：2004-08-31 00:00:00

abstract：BACKGROUND:Current standards for assessment of tumour response to therapy (a) categorise therapeutic efficacy values, inappropriate for patient-specific and deterministic studies, (b) neglect the natural growth characteristics of tumours, (c) are based on tumour shrinkage, inappropriate for cytostatic therapies, and (d...

journal_title：British journal of cancer

authors： Mehrara E,Forssell-Aronsson E,Bernhardt P

更新日期：2011-08-23 00:00:00

abstract：:We have evaluated the relation between cancer of the lower urinary tract ("bladder cancer") and the use of artificial sweeteners, by means of case-control studies in Manchester, U.K., and Nagoya, Japan, areas where extensive use occurred 30-40 years ago. In each area, a broadly based series of cases (555 in Manchester...

journal_title：British journal of cancer

authors： Morrison AS,Verhoek WG,Leck I,Aoki K,Ohno Y,Obata K

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:This study explored the association between smoking and colorectal malignant carcinoma (CRC) in the Chinese population at the national level for the first time. METHODS:In the China Nationwide Retrospective Mortality Survey conducted during 1989-1991, 12,942 CRC cases among 1,136,336 all-cause deaths aged ≥...

journal_title：British journal of cancer

authors： Hou L,Jiang J,Liu B,Nasca PC,Wu Y,Zou X,Han W,Chen Y,Zhang B,Xue F,Pang H,Li J

更新日期：2014-03-04 00:00:00

abstract：BACKGROUND:To document the effect of bivalent HPV immunisation on cervical cytology as a screening test and assess the implications of any change, using a retrospective analysis of routinely collected data from the Scottish Cervical Screening Programme (SCSP). METHODS:Data were extracted from the Scottish Cervical Cal...

journal_title：British journal of cancer

authors： Palmer TJ,McFadden M,Pollock KG,Kavanagh K,Cuschieri K,Cruickshank M,Cotton S,Nicoll S,Robertson C

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Oral squamous cell carcinoma (OSCC) has increased morbidity, and its high metastatic potential affects patient survival. Bromodomain containing 4 (BRD4) is a chromatin protein that associates with acetylated histone lysines and facilitates transcription. BRD4 has been implicated in cell proliferation, metast...

journal_title：British journal of cancer

authors： Yamamoto T,Hirosue A,Nakamoto M,Yoshida R,Sakata J,Matsuoka Y,Kawahara K,Nagao Y,Nagata M,Takahashi N,Hiraki A,Shinohara M,Nakao M,Saitoh N,Nakayama H

更新日期：2020-08-01 00:00:00