Abstract:
BACKGROUND:Little is known about leukaemia risk following chronic radiation exposures at low dose rates. The Techa River Cohort of individuals residing in riverside villages between 1950 and 1961 when releases from the Mayak plutonium production complex contaminated the river allows quantification of leukaemia risks associated with chronic low-dose-rate internal and external exposures. METHODS:Excess relative risk models described the dose-response relationship between radiation dose on the basis of updated dose estimates and the incidence of haematological malignancies ascertained between 1953 and 2007 among 28 223 cohort members, adjusted for attained age, sex, and other factors. RESULTS:Almost half of the 72 leukaemia cases (excluding chronic lymphocytic leukaemia (CLL)) were estimated to be associated with radiation exposure. These data are consistent with a linear dose response with no evidence of modification. The excess relative risk estimate was 0.22 per 100 mGy. There was no evidence of significant dose effect for CLL or other haematopoietic malignancies. CONCLUSION:These analyses demonstrate that radiation exposures, similar to those received by populations exposed as a consequence of nuclear accidents, are associated with long-term dose-related increases in leukaemia risks. Using updated dose estimates, the leukaemia risk per unit dose is about half of that based on previous dosimetry.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Krestinina LY,Davis FG,Schonfeld S,Preston DL,Degteva M,Epifanova S,Akleyev AVdoi
10.1038/bjc.2013.614subject
Has Abstractpub_date
2013-11-26 00:00:00pages
2886-93issue
11eissn
0007-0920issn
1532-1827pii
bjc2013614journal_volume
109pub_type
杂志文章abstract::HuR, a ubiquitously expressed member of the Hu protein family that binds and stabilizes an AU-rich element (ARE)-containing mRNAs, is known to shuttle between the nucleus and the cytoplasm via several export pathways. When normal cells were treated with heat shock, HuR was exported to the cytoplasm in a chromosome mai...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6605084
更新日期:2009-06-16 00:00:00
abstract::Growth factor-induced migration is a rate-limiting step in tumour invasiveness. The molecules that regulate this cellular behaviour would represent novel targets for limiting tumour cell progression. Epidermal growth factor (EGF) receptor (EGFR)-mediated motility, present in both autocrine and paracrine modes in prost...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603234
更新日期:2006-07-17 00:00:00
abstract:BACKGROUND:Limited literature on the role of intraarterial chemotherapy as first-line therapy for penile squamous cell carcinoma is available. METHODS:From 2005 to 2013, a total of 12 patients with various stages of penile squamous cell carcinoma received intraarterial chemotherapy. The chemotherapeutic agents used we...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.394
更新日期:2014-09-09 00:00:00
abstract::beta2-Microglobulin (beta2M), a component of MHC class I molecules, is believed to be associated with tumour status in various cancers. In this study, we examined the expression of beta2M at different malignant stages of oral cavity squamous cell carcinoma (OCSCC). To determine the possible correlation between beta2M ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604698
更新日期:2008-11-04 00:00:00
abstract::Dynamic contrast-enhanced MR imaging (DCE-MRI) may act as a biomarker for successful cancer therapy. Simple, reproducible techniques may widen this application. This paper demonstrates a single slice imaging technique. The image acquisition is performed in less than 500 ms making it relatively insensitive to respirato...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603140
更新日期:2006-05-22 00:00:00
abstract::Trends in long-term relative survival from breast cancer are examined for women diagnosed in England and Wales up to 2001, using both period and hybrid approaches. Large improvements in long-term survival are predicted. Women with breast cancer still experience persistent excess mortality up to at least 20 years after...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603668
更新日期:2007-04-10 00:00:00
abstract::In the first part of this study the availability of folinic acid (FA) and its main active circulating metabolite, 5-methyltetrahydrofolate (5-MTHF), were studied in plasma and cerebrospinal fluid (CSF) from normal subjects after i.v. administration of 100 and 250 mg of FA. 5-MTHF rapidly appeared in plasma, the maximu...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1989.127
更新日期:1989-04-01 00:00:00
abstract::Progression of colorectal cancer may follow either of two main genetic routes: the chromosome- or microsatellite-instability pathways. Association between the patients' prognosis and microsatellite instability has been questioned. Improved survival has previously been found in patients with expression of HLA-DR antige...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600507
更新日期:2002-09-23 00:00:00
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journal_title:British journal of cancer
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doi:10.1038/sj.bjc.6690685
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6600030
更新日期:2002-01-07 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602363
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abstract::To examine whether weight loss at presentation influences outcome in patients who received chemotherapy for lung cancer or mesothelioma. Multivariate analysis of prospectively collected data 1994-2001. Data were available for age, gender, performance status, histology, stage, response, toxicity, progression-free and o...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6601781
更新日期:2004-05-17 00:00:00
abstract::The results of treating two series of patients with Burkitt's lymphoma are presented in the form of survival curves. The second series shows an improved survival rate which seems to be due to a potentiating effect by potassium iodide on oral cyclophosphamide. So far no reason for this effect has been found. ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1971.6
更新日期:1971-03-01 00:00:00
abstract::The met proto-oncogene is the tyrosine kinase growth factor receptor for hepatocyte growth factor. In the present study, we investigated the role of met expression on the modulation of apoptosis in colorectal tumours. The gene expressions of c-met and the anti-apoptotic bcl-2 family, including bcl-2, bcl-x(L)and bcl-w...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1301
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doi:10.1038/sj.bjc.6603713
更新日期:2007-05-07 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2013.408
更新日期:2013-08-20 00:00:00
abstract::A crude membrane fraction isolated from mouse tumour cells was treated with various chemicals. The effects on the immunogenicity of the membrane sample were tested in syngeneic mice for tumour protection, using a challenge dose of 10(5) viable tumour cells. Best protection was obtained after immunization of mice with ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.236
更新日期:1978-10-01 00:00:00
abstract::Three intraperitoneal human ovarian cancer xenografts (OS, HU, and LA) were used to assess the antitumour activity of intraperitoneal therapy with liposome encapsulated MTP-PE. MTP-PE led to significant prolongation of survival in all three xenograft models, but with varying efficacy. In one tumour model (OS), 80% of ...
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pub_type: 杂志文章
doi:10.1038/bjc.1991.92
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abstract::Hepatocellular carcinoma (HCC) is one of the most malignant human tumours because of its high incidence of metastasis. The mechanisms underlying the metastasis of HCC, however, remain poorly understood. In this study, we performed cDNA microarray analysis to profile gene expression patterns in two subtypes of HCC, sol...
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journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
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更新日期:1994-10-01 00:00:00
abstract::The topical carcinogenicity to mouse skin of smoke condensates obtained from a tobacco substitute (NSM), alone or in combination with tobacco, has been compared with condensate from tobacco and with acetone, the solvent used. Sixteen different types of cigarette were used to make the condensates, and the age-standardi...
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doi:10.1038/bjc.1971.40
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journal_title:British journal of cancer
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abstract::To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations we...
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pub_type: 杂志文章
doi:10.1038/bjc.1997.205
更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2010-02-02 00:00:00