Abstract:
:The pharmacokinetics and pharmacodynamics of oral S-1, a dihydropyrimidine dehydrogenase (DPD) inhibitory fluoropyrimidine, were compared with those of protracted venous infusion (PVI) of 5-fluorouracil (5-FU). In all, 10 patients with gastric cancer received PVI of 5-FU at a dose of 250 mg m(-2) day(-1) for 5 days. After a washout period of 9 days, the patients received two divided doses daily for 28 days. S-1 was administered orally at about 0900 and 1900 hours. The daily dose of S-1 in terms of tegafur was 80 mg day(-1) in patients with a body surface area (BSA) of <1.25 m(2), 100 mg day(-1) in those with a BSA of >or=1.25 m(2) to <1.5 m(2), and 120 mg day(-1) in those with a BSA of >or=1.5 m(2). Plasma concentrations of 5-FU and F-beta-alanine (FBAL) were measured for pharmacokinetic analysis, and the plasma uracil concentration was monitored as a surrogate marker of DPD inhibition (pharmacodynamic analysis) in the same patients on days 1-5 of PVI of 5-FU and on days 1-5 of oral S-1. The area under the curve (AUC(0-10 h)) of 5-FU on day 5 was 728+/-113 ng h ml(-1) for PVI of 5-FU and 1364+/-374 ng h ml(-1) for S-1. The median 5-FU PVI : S-1 ratio of the AUC(0-10 h) of 5-FU was 1.9. The AUC(0-10 h) of FBAL on day 5 of PVI of 5-FU was 9465+/-3225 ng h ml(-1), AUC(0-10 h), as compared with 1725+/-605 ng h ml(-1) on day 5 of S-1 treatment. The AUC(0-10 h) of uracil on day 5 was 252+/-60 ng h ml(-1) with PVI of 5-FU and 12 582+/-3060 ng h ml(-1) with S-1. The AUC(0-10 h) of FBAL was markedly lower and plasma uracil concentrations were significantly higher for S-1 than for PVI of 5-FU, clearly demonstrating the effect of DPD inhibition.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Yamada Y,Hamaguchi T,Goto M,Muro K,Matsumura Y,Shimada Y,Shirao K,Nagayama Sdoi
10.1038/sj.bjc.6601224subject
Has Abstractpub_date
2003-09-01 00:00:00pages
816-20issue
5eissn
0007-0920issn
1532-1827pii
6601224journal_volume
89pub_type
杂志文章abstract:BACKGROUND:While lung adenocarcinoma patients can somewhat benefit from anti-angiogenic therapies, patients with squamous cell lung carcinoma (SQLC) cannot. The reasons for this discrepancy remain largely unknown. Soluble VEGF receptor-1, namely sVEGFR1-i13, is a truncated splice variant of the cell membrane-spanning V...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/s41416-018-0128-4
更新日期:2018-06-01 00:00:00
abstract::The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We r...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600326
更新日期:2002-06-17 00:00:00
abstract::The metabolism of serotonin was studied in cancer patients of their first day of their first course of chemotherapeutic drugs either with strongly or moderately emetogenic regimens. It was observed that strongly emetogenic treatments induce greater increases in serotonin release than moderately emetogenic regimens. Hi...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.242
更新日期:1992-07-01 00:00:00
abstract::Genomic alterations in the p53 tumour-suppressor gene and overexpression of p53 protein, resulting from gene mutations, are frequently found in pancreatic cancer. In this study we analysed the sera of 160 patients with malignant and benign pancreatic diseases for the presence of circulating antibodies to the p53 prote...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1994.443
更新日期:1994-11-01 00:00:00
abstract:BACKGROUND:There are limited data on surgical outcomes in gynaecological oncology. We report on predictors of complications in a multicentre prospective study. METHODS:Data on surgical procedures and resulting complications were contemporaneously recorded on consented patients in 10 participating UK gynaecological can...
journal_title:British journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1038/bjc.2014.630
更新日期:2015-02-03 00:00:00
abstract::Women with gross cystic breast disease may have an increased risk of breast cancer. In this study the ability of breast cyst fluid (BCF), obtained from British or Hungarian women, to modulate oestrone sulphate (E1S) formation or hydrolysis, has been examined. For this, oestrogen receptor-positive (ER+) MCF-7 or MDA-MB...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.0948
更新日期:2000-01-01 00:00:00
abstract::In vitro studies identified three Burkitts lymphoma cell lines, Ramos, MUTU-I and Daudi, that were growth inhibited by anti-IgM antibody. However, only Ramos and MUTU-I were sensitive to monoclonal antibodies (mAb) recognizing the Fc region of surface IgM (anti-Fc mu). Experiments using anti-Fc mu mAb (single or non-c...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690136
更新日期:1999-02-01 00:00:00
abstract::Data obtained from multiple sources indicate that no single mechanism can explain the resistance to chemotherapy exhibited by non-small cell lung carcinomas. The multi-factorial nature of drug resistance implies that the analysis of comprising expression profiles may predict drug resistance with higher accuracy than s...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6600463
更新日期:2002-07-29 00:00:00
abstract::Preclinical studies have demonstrated the synergistic anti-tumour activity of combination therapy with the oral cytostatics, 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide (CPA), in human breast cancer xenograft models. This study was performed to evaluate the efficacy and safety of this oral combination chem...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601350
更新日期:2003-11-03 00:00:00
abstract:BACKGROUND:It has been hypothesised that intrauterine exposures are important for subsequent prostate cancer risk. Prior epidemiological studies have used birthweight as a proxy of cumulative intrauterine exposures to test this hypothesis, but results have been inconsistent partly because of limited statistical power. ...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-03-29 00:00:00
abstract:BACKGROUND:Ovarian cancer is frequently advanced at presentation when treatment is rarely curative. Response to first-line platinum-based chemotherapy significantly influences survival, but clinical response is unpredictable and is frequently limited by the development of drug-resistant disease. METHODS:We used qRT-PC...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.410
更新日期:2012-10-09 00:00:00
abstract::Acute inflammatory reactions were induced in rats by the intravenous injection of cellulose sulphate (CS) or an extract of normal rat lung homogenate (LH), or by intraperitoneal injections of Compound 48/80. These treatments greatly increased survival and clonogenic growth in the lungs of rats of intravenously injecte...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1974.189
更新日期:1974-09-01 00:00:00
abstract:BACKGROUND:In metastatic colorectal cancer (mCRC), KRAS is the only validated biomarker used to select patients for administration of epidermal growth factor receptor (EGFR)-targeted therapies. To identify additional predictive markers, we investigated the importance of HER2, the primary EGFR dimerisation partner, in t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2013.4
更新日期:2013-02-19 00:00:00
abstract::The relationship between hepatic arterial albumin microsphere distribution and hepatic arterial blood flow and the effects of regional angiotensin II were studied in a rat liver metastases model. Hooded-Lister rats were inoculated subcapsularly with 2 x 10(6) HSN sarcoma cells. At 20 days, hepatic arterial blood flow ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.258
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:To estimate the accuracy of one-step nucleic acid amplification (OSNA) assay as an intra-operative sentinel lymph node biopsy (SLNB) for sentinel lymph node (SLN) metastasis in breast cancer. METHODS:PubMed, Cochrane Library and Web of Science databases were searched by two independent reviewers to retrieve...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1038/bjc.2017.262
更新日期:2017-10-10 00:00:00
abstract::Resistance to cytotoxics precludes the successful treatment of many solid tumours. Inhibition of DNA synthesis in normal tissues with antimetabolites such as hydroxyurea (HU) may be a useful means of improving the selective uptake of toxic thymidine analogues by the relatively resistant tumour cells. HU also inhibits ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.120
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer. METHODS:In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pan...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2017.355
更新日期:2017-12-05 00:00:00
abstract::Oral capecitabine is a highly active, well-tolerated and convenient treatment for breast and colorectal cancer. This trial assessed the efficacy and safety of single-agent capecitabine in patients with previously treated ovarian cancer. A total of 29 patients with platinum-pretreated relapsed ovarian cancer were enrol...
journal_title:British journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1038/sj.bjc.6601381
更新日期:2003-11-17 00:00:00
abstract::We analysed 29 consecutive cases of primary gastric lymphoma (20 men and 9 women) treated in our unit between January 1977 and May 1983. Median age was 55 years. Abdominal pain and weight loss were the main presenting symptoms while there was no palpable disease in the majority of cases. Upper gastrointestinal radiolo...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1985.206
更新日期:1985-09-01 00:00:00
abstract::Dendritic cells (DC) are professional antigen-presenting cells that play a pivotal role in the induction of immunity. Ex vivo-generated, tumour antigen-loaded mature DC are currently exploited as cancer vaccines in clinical studies. However, antigen loading and maturation of DC directly in vivo would greatly facilitat...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603341
更新日期:2006-10-09 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.2016.173
更新日期:2016-07-12 00:00:00
abstract::BALB/c mice born to and nursed by females immunized against MSV-M showed a reduced tumour incidence and a high tumour regression rate following MSV-M injection at 7-14 days of age. Females immunized long before mating could also confer protection to their offspring whereas females immunized after parturition could not...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1973-09-01 00:00:00
abstract:BACKGROUND:Though p53 mutations are rare in ES, there is a strong indication that p53 mutant tumours form a particularly bad prognostic group. As such, novel treatment strategies are warranted that would specifically target and eradicate tumour cells containing mutant p53 in this subset of ES patients. METHODS:PRIMA-1...
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pub_type: 杂志文章
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更新日期:2013-11-12 00:00:00
abstract:BACKGROUND:Epigenetic silencing by promoter methylation and chromatin remodelling affects hundreds of genes and is a causal event for lung cancer. Treatment of patients with low doses of the demethylating agent 5-azacytidine in combination with the histone deacetylase inhibitor entinostat has yielded clinical responses...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2013-10-01 00:00:00
abstract::The relationship between aspirin use and colorectal cancer risk was examined by a case-control study in Italy. Regular aspirin use was reported by only 47 (3.5%) cases and 77 (4.1%) control subjects, giving a multivariate odds ratio (OR) of 0.7 (95% CI 0.5-1.0) after allowance for education, physical exercise and sele...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.444
更新日期:1997-01-01 00:00:00
abstract::The relationship between circulating C-reactive protein concentrations and potential cytokine and receptor mediators (interleukin-6, leukaemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), soluble IL-6 receptor, soluble gp130, soluble TNF receptor, interleukin-1 receptor antagonist and interleukin-8 (IL...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602248
更新日期:2004-12-13 00:00:00
abstract::The aim of this study was to investigate the expression of the protein tyrosine phosphatases (PTP) PRL-1, PRL-2, and PRL-3 in human breast cancer and to evaluate its clinical and prognostic significance. PRL-PTP mRNA expression was examined in malignant (n = 7) and nonmalignant (n = 7) cryoconserved breast tissue samp...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603261
更新日期:2006-08-07 00:00:00
abstract::To test the hypothesis that steroid hormone receptor expression is particularly pronounced in breast tumours when compared with non-neoplastic tissue, mastectomy samples were divided into 16 sectors. Multifocal tumours, of varying receptor phenotype were found in 4 patients and in addition different regions of large t...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1987.90
更新日期:1987-04-01 00:00:00
abstract::Regionally administered vasopressors might increase tumour chemotherapy uptake by differentially constricting normal and tumour blood vessels, leading to a selective increase in blood flow to the tumour. In this study, we compared the effects of the vasopressors angiotensin II, vasopressin and endothelin I and the vas...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1997.534
更新日期:1997-01-01 00:00:00
abstract::Cancer Research UK has recently sponsored a meeting, organized by the UK Medical Research Council, on cancer drug resistance. Several of the molecular mechanisms responsible for this clinical outcome, such as DNA interstrand crosslink repair, apoptosis evasion, cytochrome P450 and P-glycoprotein, were discussed. There...
journal_title:British journal of cancer
pub_type:
doi:10.1038/sj.bjc.6602821
更新日期:2005-10-31 00:00:00