Abstract:
:The origin of metastatic adenocarcinoma lesions can sometimes be difficult to diagnose. The objectives of our study were to establish the cytokeratin staining pattern of primary and metastatic lung and colorectal adenocarcinomas, and to determine if this helps to identify the site of origin of metastatic lesions. We reviewed a total of 102 tissue samples from patients in our tumour registry, with either primary or metastatic lung or colorectal adenocarcinoma. Tissue sections were stained for cytokeratin 7 and 20 and read as positive or negative for staining. Clinical and radiologic information was reviewed from computerised charts. The cytokeratin 7+/cytokeratin 20- pattern characterised 96% (29 out of 30) of primary and 95% (21 out of 22) of metastatic lung adenocarcinomas. All the primary (26), and 88% (21 out of 24) of metastatic colorectal adenocarcinomas stained cytokeratin 7-/cytokeratin 20+. Samples from a variety of metastatic sites were evaluated for cytokeratin 7 and 20 staining. Out of the 102 samples, in 95% (97 out of 102) of the cases, the cytokeratin 7 and cytokeratin 20 staining pattern characterised and differentiated between lung and colorectal adenocarcinoma. Primary and metastatic lung adenocarcinomas show a cytokeratin 7+/cytokeratin 20- staining pattern, while colorectal adenocarcinomas stain cytokeratin 7-/cytokeratin 20+. Cytokeratin staining is helpful in the diagnostic differentiation of metastatic lesions from these two common primaries, and assists in determining the site of origin of metastatic lesions.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Kummar S,Fogarasi M,Canova A,Mota A,Ciesielski Tdoi
10.1038/sj.bjc.6600326subject
Has Abstractpub_date
2002-06-17 00:00:00pages
1884-7issue
12eissn
0007-0920issn
1532-1827journal_volume
86pub_type
杂志文章abstract:BACKGROUND:A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is currently the best predictor of responsiveness towards immune checkpoint blockade. Data about the prevalence of high-level microsatellite instability in cholangiocarc...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:British journal of cancer
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abstract:BACKGROUND:Cytochrome P450 2D6 (CYP2D6) has a crucial role in the metabolic conversion of tamoxifen into the active metabolite endoxifen. In this cohort study, the effect of CYP2D6-predicted phenotype, defined as the combined effect of CYP2D6 genetic variation and concomitant use of CYP2D6-inhibiting medication, on tim...
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更新日期:2010-09-07 00:00:00
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journal_title:British journal of cancer
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doi:10.1038/sj.bjc.6605641
更新日期:2010-04-13 00:00:00
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journal_title:British journal of cancer
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更新日期:1998-01-01 00:00:00
abstract::The frequency, in women with breast cancer, of mutations and other variants in the susceptibility gene, BRCA1, was investigated using a population-based case-control-family study. Cases were women living in Melbourne or Sydney, Australia, with histologically confirmed, first primary, invasive breast cancer, diagnosed ...
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6604777
更新日期:2008-12-02 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6602963
更新日期:2006-02-27 00:00:00
abstract::Pamidronate belongs to the class of nitrogen-containing bisphosphonates that are potent inhibitors of bone resorption frequently used for the treatment of osteoporosis and cancer-induced osteolysis. The inhibition of osteoclasts' growth has been suggested as the main mechanism of the inhibitory effect of pamidronate o...
journal_title:British journal of cancer
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doi:10.1038/sj.bjc.6600476
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pub_type: 杂志文章
doi:10.1054/bjoc.2001.1904
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.106
更新日期:1978-05-01 00:00:00
abstract::We have analysed 174 gastric carcinomas from the United Kingdom and from Japan for the presence of Epstein-Barr virus (EBV) using in situ hybridisation for the small EBV-encoded nuclear RNAs (EBERs). EBV was detected in the tumour cells in all of six undifferentiated gastric carcinomas with prominent lymphoid stroma (...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1993.472
更新日期:1993-11-01 00:00:00
abstract::Malignant melanoma (MM) is thought to arise by sequential accumulation of genetic alterations in normal melanocytes. Previous cytogenetic and molecular studies indicated the 9p21 as the chromosomal region involved in MM pathogenesis. In addition to the CDKN genes (p16/CDKN2A, p15/CDKN2B and p19(ARF), frequently inacti...
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pub_type: 杂志文章
doi:10.1054/bjoc.2000.1513
更新日期:2000-12-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1988.88
更新日期:1988-04-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2011.283
更新日期:2011-09-06 00:00:00
abstract::Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG...
journal_title:British journal of cancer
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doi:10.1038/sj.bjc.6600877
更新日期:2003-04-22 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1978.281
更新日期:1978-12-01 00:00:00
abstract::Tumour angiogenesis is essential for progression of solid tumours and constitutes an interesting target for therapy. However, impaired tumour blood supply may also be an important obstacle for treatment by radiotherapy and chemotherapy. Estramustine has been shown to increase tumour blood flow and potentiate the effec...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690333
更新日期:1999-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/bjc.2014.306
更新日期:2014-08-26 00:00:00
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journal_title:British journal of cancer
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journal_title:British journal of cancer
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更新日期:2012-08-21 00:00:00
abstract::Within a population-based cohort study, 40,708 men aged 45-79 years followed from 1998 to 2004. After adjusting for potential confounders, we observed a strong inverse linear association between total daily physical activity (PA) and death from cancer (n=1153). For each increment of 4 metabolic equivalent (MET)-h day(...
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更新日期:2008-06-03 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
abstract::We followed 353 women referred with abnormal cervical cytology in a non-intervention cohort study. In 91 pregnant women we compared high-risk human papilloma virus rates in the subsequent trimesters and postpartum in comparison to 262 non-pregnant women. High-risk human papilloma virus clearance was compared with 179 ...
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pub_type: 杂志文章
doi:10.1038/sj.bjc.6600367
更新日期:2002-07-01 00:00:00
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abstract::We followed a population-based cohort of 5696 women, 32-38 years of age, by registry linkage with cytology and pathology registries during a mean follow-up time of 4.1 years to assess the importance for CIN2+ development of type-specific HPV DNA positivity at baseline. HPV 16, 31 and 33 conveyed the highest risks and ...
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pub_type: 杂志文章,多中心研究
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journal_title:British journal of cancer
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doi:10.1038/bjc.1976.179
更新日期:1976-10-01 00:00:00
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journal_title:British journal of cancer
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doi:10.1038/bjc.1986.190
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abstract::The haemodynamics of the uterine arteries and myometrium were assessed using Doppler ultrasound in forty consecutive patients requiring treatment for invasive mole and choriocarcinoma. The investigations were performed prior to the commencement of chemotherapy and the subjects followed prospectively. The Doppler wavef...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.379
更新日期:1992-11-01 00:00:00