Abstract:
:It has been reported that the rho genes, which consist of a ras-related small GTPase protein family, regulate cytoskeletal structures and have the potential to transform cultured cells. To investigate the biological relevance of the rho genes in pancreatic carcinogenesis, we examined expressions of the rhoA, B and C genes by polymerase chain reaction after reverse transcription (RT-PCR) in 33 cases of ductal adenocarcinoma of the pancreas. In addition, mutations of the K-ras, rhoA, B and C genes were studied in the same series of tumour tissues to correlate with rho gene expressions. The expression levels of the rhoC gene were significantly higher in tumours than in non-malignant portions (P < 0.001). Metastatic lesions overexpressed the rhoC gene compared with primary tumours (P < 0.05). Carcinoma tissues with perineural invasion and lymph node metastasis exhibited significantly higher expressions of the rhoC gene than tumours without these manifestations (P < 0.001 and P < 0.05 respectively). Overexpression of the rhoC gene significantly correlated with poorer prognosis of patients with pancreatic adenocarcinoma (P < 0.05). In contrast, the expression levels of the rhoA and B genes showed no significant relationship with clinicopathological findings. Mutation was not found either in the rhoA, B or C gene sequences examined. K-ras gene mutation, detected in 27 out of 33 (81.8%) cases, did not affect the expression levels in any of the rho genes. These suggest that elevated expression of the rhoC gene may be involved in the progression of pancreatic carcinoma independent of K-ras gene activation.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Suwa H,Ohshio G,Imamura T,Watanabe G,Arii S,Imamura M,Narumiya S,Hiai H,Fukumoto Mdoi
10.1038/bjc.1998.23subject
Has Abstractpub_date
1998-01-01 00:00:00pages
147-52issue
1eissn
0007-0920issn
1532-1827journal_volume
77pub_type
杂志文章abstract:BACKGROUND:Several studies have reported discordant results regarding the impact of the CYP2D6 phenotype on both the effectiveness and the degree of endocrine symptoms associated with tamoxifen. Other studies have suggested that menopausal symptoms may be a predictive factor to tamoxifen response. METHODS:We investiga...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2012.278
更新日期:2012-07-10 00:00:00
abstract::Oesophageal adenocarcinoma has become much more common over the past 50 years, particularly in Britain, with an unexplained male to female ratio of > 4:1. Given the use of asbestos filtration in commercial brewing and reports of its unregulated use in British public houses in the 1970's to clear draught beer "slops", ...
journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/s41416-019-0467-9
更新日期:2019-06-01 00:00:00
abstract::Electrochemotherapy is an anti-tumour treatment that utilizes locally delivered electric pulses to increase cytotoxicity of chemotherapeutic drugs. The aim of our study was to determine whether anti-tumour effectiveness of electrochemotherapy with cisplatin is a consequence of increased plasma membrane permeability ca...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6690222
更新日期:1999-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.1999.1067
更新日期:2000-03-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/sj.bjc.6602963
更新日期:2006-02-27 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1996-06-01 00:00:00
abstract:BACKGROUND:In the phase III AVAGAST trial, the addition of bevacizumab to chemotherapy improved progression-free survival (PFS) but not overall survival (OS) in patients with advanced gastric cancer. We studied the role of Angiopoietin-2 (Ang-2), a key driver of tumour angiogenesis, metastasis and resistance to antiang...
journal_title:British journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1038/bjc.2016.30
更新日期:2016-04-12 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1995.89
更新日期:1995-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-09-02 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1983.174
更新日期:1983-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1054/bjoc.2000.1708
更新日期:2001-04-06 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1982.269
更新日期:1982-11-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
doi:10.1038/bjc.1995.323
更新日期:1995-08-01 00:00:00
abstract::Darbepoetin alfa (Aranesp), Amgen) is a novel erythropoiesis-stimulating protein with a serum half-life longer than recombinant human erythropoietin (Epo), used in the treatment of cancer-associated anaemia. Anaemia is known to adversely affect prognosis and response to treatment in cancer patients. Solid tumours cont...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602685
更新日期:2005-07-25 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2013-10-29 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1992.255
更新日期:1992-08-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1996.176
更新日期:1996-04-01 00:00:00
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journal_title:British journal of cancer
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更新日期:2017-10-10 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6603448
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journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2006-11-06 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6601614
更新日期:2004-02-09 00:00:00
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pub_type: 杂志文章
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更新日期:2006-06-19 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2015-01-06 00:00:00
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pub_type: 杂志文章
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更新日期:2002-07-29 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2017-08-08 00:00:00
abstract:BACKGROUND:The overexpression of oestrogen-related receptor-β (ERRβ) in breast cancer patients is correlated with improved prognosis and longer relapse-free survival, and the level of ERRβ mRNA is inversely correlated with the S-phase fraction of cells from breast cancer patients. METHODS:Chromatin immunoprecipitation...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2014-04-15 00:00:00
abstract:BACKGROUND:Expression of epithelial cell adhesion molecule (EpCAM) is deregulated in epithelial malignancies. Beside its role in cell adhesion, EpCAM acts as signalling molecule with tumour-promoting functions. Thus, EpCAM is part of the molecular network of oncogenic receptors and considered an interesting therapeutic...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2014.366
更新日期:2014-08-26 00:00:00
abstract::Germline mutations in genes encoding proteins involved in DNA mismatch repair are responsible for the autosomal dominantly inherited cancer predisposition syndrome hereditary nonpolyposis colorectal cancer (HNPCC). We describe here analysis of hMLH1 and hMSH2 in nine Greek families referred to our centre for HNPCC. A ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/sj.bjc.6602260
更新日期:2005-01-31 00:00:00