MicroRNA in lung cancer.

abstract：BACKGROUND:The Obermair nomogram was recently developed to predict the risk of relapse in patients with borderline ovarian tumours (BOTs) based on five readily available clinical, biological, and pathological characteristics. We set out to externally validate and assess its robustness using a multi-institutional BOT da...

journal_title：British journal of cancer

authors： Bendifallah S,Uzan C,Fauvet R,Morice P,Darai E

更新日期：2013-11-26 00:00:00

abstract：BACKGROUND:Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated in patients with recurrent or refractory acute myeloid leukaemia (AML) or advanced solid tumours. ME...

journal_title：British journal of cancer

authors： Cortes J,Tamura K,DeAngelo DJ,de Bono J,Lorente D,Minden M,Uy GL,Kantarjian H,Chen LS,Gandhi V,Godin R,Keating K,McEachern K,Vishwanathan K,Pease JE,Dean E

更新日期：2018-05-01 00:00:00

abstract：:In 101 breast cancer patients, measurement of oestrogen receptor status in multiple biopsies across a tumour reveals a highly significant difference in the proportion of patients remaining either disease-free (P less than 0.04) or alive (P less than 0.005), when those with uniformly receptor positive (++) primary tumo...

journal_title：British journal of cancer

authors： Castagnetta L,Traina A,Di Carlo A,Carruba G,Lo Casto M,Mesiti M,Leake R

更新日期：1989-04-01 00:00:00

abstract：:We examined the levels of expression of the multidrug resistance-associated protein (MRP) gene quantified by Northern blot analysis in comparison with those of the MDR1 gene determined by reverse transcription-polymerase chain reaction (RT-PCR) in 104 non-small-cell lung cancer (NSCLC) specimens [59 adenocarcinoma (Ad...

journal_title：British journal of cancer

authors： Ota E,Abe Y,Oshika Y,Ozeki Y,Iwasaki M,Inoue H,Yamazaki H,Ueyama Y,Takagi K,Ogata T

更新日期：1995-09-01 00:00:00

abstract：:A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed to react preferentially with nucleic acids over sulphur ligands such as glutathione. This report documents the ...

journal_title：British journal of cancer

authors： Holford J,Sharp SY,Murrer BA,Abrams M,Kelland LR

更新日期：1998-01-01 00:00:00

abstract：:A sedentary lifestyle, obesity, and a Westernized diet have been implicated in the aetiology of both colorectal cancer and non-insulin dependent diabetes mellitus, leading to the hypothesis that hyperinsulinaemia may promote colorectal cancer. We prospectively examined the association between colorectal cancer risk an...

journal_title：British journal of cancer

authors： Nilsen TI,Vatten LJ

更新日期：2001-02-02 00:00:00

abstract：:Low-dose hyper-radiosensitivity (HRS) (below 0.5 Gy) has been extensively documented in the past few years. The molecular basis of this phenomenon remains largely unknown and the purpose of this study was to investigate the possible implication of the DNA repair DNA-PK complex. The activity of the DNA-PK complex, i.e....

journal_title：British journal of cancer

authors： Vaganay-Juéry S,Muller C,Marangoni E,Abdulkarim B,Deutsch E,Lambin P,Calsou P,Eschwege F,Salles B,Joiner M,Bourhis J

更新日期：2000-08-01 00:00:00

abstract：:For stage III non-small cell lung cancer (NSCLC), approximately a third of patients survive up to 5 years, with decreasing 5-year survival rates for stage IIIB and stage IIIC disease. Although curable, stage III NSCLC encompasses a diverse range of disease presentation, with an equally complex range of multi-modal tre...

journal_title：British journal of cancer

authors： Evison M,AstraZeneca UK Limited.

更新日期：2020-12-01 00:00:00

abstract：:Vascular endothelial growth factor-C (VEGF-C) functions specifically to induce lymphangiogenesis. We examined the relationship between expression of VEGF-C and clinicopathological features in patients with colorectal cancer. The expression of VEGF-C in the 99 primary tumours and 18 metastatic lymph nodes from colorect...

journal_title：British journal of cancer

authors： Akagi K,Ikeda Y,Miyazaki M,Abe T,Kinoshita J,Maehara Y,Sugimachi K

更新日期：2000-10-01 00:00:00

abstract：:Incidence and mortality data, stage of disease and treatment information for female breast cancer were obtained for the years 1975-1999 for the former Yorkshire Regional Health Authority area, from the Northern and Yorkshire Cancer Registry and Information Service. Deaths by age group and 3-year calendar period were s...

journal_title：British journal of cancer

authors： Pisani P,Forman D

更新日期：2004-02-09 00:00:00

abstract：BACKGROUND:The prognostic and predictive value of multiple serum biomarkers was evaluated using samples from a randomised phase III study (HORIZON II) investigating chemotherapy with or without cediranib in metastatic colorectal cancer (mCRC). METHODS:Baseline levels of 207 protein markers were measured in serum sampl...

journal_title：British journal of cancer

authors： Spencer SK,Pommier AJ,Morgan SR,Barry ST,Robertson JD,Hoff PM,Jürgensmeier JM

更新日期：2013-11-26 00:00:00

abstract：:Elevated expression of matrix metalloproteinases (MMPs), a family of secreted proteinases that degrade matrix components of basement membranes and connective tissues, is strongly correlated with malignant expression in various human epithelial cancers and epithelial cancer cell lines. We have tested whether elevated l...

journal_title：British journal of cancer

authors： Meade-Tollin LC,Boukamp P,Fusenig NE,Bowen CP,Tsang TC,Bowden GT

更新日期：1998-03-01 00:00:00

abstract：:The overall tumour incidence and breast cancer incidence related to hormone replacement therapy (HRT) were followed in a population-based cohort of 29 508 women, aged 25-65 when interviewed in 1990-92. By the end of the follow up in December 1999, there were 226 611 person-years of observation. A total of 1145 maligna...

journal_title：British journal of cancer

authors： Olsson H,Bladström A,Ingvar C,Möller TR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:In the coBRIM study, cobimetinib plus vemurafenib (C+V) significantly improved survival outcomes vs placebo and vemurafenib (P+V) in patients with advanced/metastatic BRAFV600-mutated melanoma. An analysis of health-related quality of life (HRQOL) from coBRIM is reported. METHODS:Patients completing the Eur...

journal_title：British journal of cancer

authors： Dréno B,Ascierto PA,Atkinson V,Liszkay G,Maio M,Mandalà M,Demidov L,Stroyakovskiy D,Thomas L,de la Cruz-Merino L,Dutriaux C,Garbe C,Bartley K,Karagiannis T,Chang I,Rooney I,Koralek DO,Larkin J,McArthur GA,Ribas A

更新日期：2018-03-20 00:00:00

abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

journal_title：British journal of cancer

authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

更新日期：2007-06-18 00:00:00

abstract：:High-dose busulphan-containing chemotherapy regimens have shown high response rates in children with relapsed or refractory neuroblastoma, Ewing's sarcoma and medulloblastoma. However, the anti-tumour activity of busulfan as a single agent remains to be defined, and this was evaluated in athymic mice bearing advanced ...

journal_title：British journal of cancer

authors： Boland I,Vassal G,Morizet J,Terrier-Lacombe MJ,Valteau-Couanet D,Kalifa C,Hartmann O,Gouyette A

更新日期：1999-02-01 00:00:00

abstract：:The idea that chemotherapy can be used in combination with immunotherapy may seem somewhat counterproductive, as it can theoretically eliminate the immune cells needed for antitumour immunity. However, much preclinical work has now demonstrated that in addition to direct cytotoxic effects on cancer cells, a proportion...

journal_title：British journal of cancer

authors： Brown JS,Sundar R,Lopez J

更新日期：2018-02-06 00:00:00

abstract：BACKGROUND:Bortezomib is a proteasome inhibitor with minimal clinical activity as a monotherapy in solid tumours, but its combination with other targeted therapies is being actively investigated as a way to increase its anticarcinogenic properties. Here, we evaluate the therapeutic potential of co-treatment with bortez...

journal_title：British journal of cancer

authors： Taylor-Harding B,Agadjanian H,Nassanian H,Kwon S,Guo X,Miller C,Karlan BY,Orsulic S,Walsh CS

更新日期：2012-01-17 00:00:00

abstract：:To evaluate the impact of prior adjuvant chemotherapy on response rate (RR), progression-free (PFS) and overall survival (OS) of metastatic breast cancer patients treated with epirubicin/paclitaxel (ET) regimens. In all, 291 patients enrolled in five studies in metastatic breast cancer were analysed: 101 (35%) were ch...

journal_title：British journal of cancer

authors： Gennari A,Bruzzi P,Orlandini C,Salvadori B,Donati S,Landucci E,Guarneri V,Rondini M,Ricci S,Conte P

更新日期：2004-03-08 00:00:00

abstract：:DNA flow cytometry was performed on formalin fixed, paraffin embedded melanocytic naevi. DNA aneuploidy was detected in all three types of naevus but was significantly more frequent in those naevi accepted as precursors of malignancy: that is, dysplastic and congenital pigmented hairy naevi. It may be that the presenc...

journal_title：British journal of cancer

authors： Newton JA,Camplejohn RS,McGibbon DH

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:The increasing incidence of oropharyngeal squamous cell carcinoma (OPSCC) is mainly related to human papillomavirus (HPV) infection. As OPSCCs are often diagnosed at an advanced stage, mortality and morbidity remain high. There are no diagnostic biomarkers for early detection of OPSCC. METHODS:Serum from 25...

journal_title：British journal of cancer

authors： Tuhkuri A,Saraswat M,Mäkitie A,Mattila P,Silén R,Dickinson A,Carpén T,Tohmola T,Joenväärä S,Renkonen S

更新日期：2018-07-01 00:00:00

abstract：:Eleven groups of workers submitted a total of 21 bronchial tumour-associated antigen preparations and 19 antisera for comparative studies. Many of the antisera proved to be polyspecific despite absorption procedures. Most of the antigen preparations contained some material reactive towards a reference antiserum to nor...

journal_title：British journal of cancer

authors： Gennings JN,Bagshawe KD,Axelsen NH,Sizaret P

更新日期：1981-10-01 00:00:00

abstract：BACKGROUND:Current evidence indicates that a stem cell-like sub-population within malignant glioblastomas, that overexpress members of the adenosine triphosphate-binding cassette (ABC) family transporters, is responsible for multidrug resistance and tumour relapse. Eradication of the brain tumour stem cell (BTSC) compa...

journal_title：British journal of cancer

authors： Martín V,Sanchez-Sanchez AM,Herrera F,Gomez-Manzano C,Fueyo J,Alvarez-Vega MA,Antolín I,Rodriguez C

更新日期：2013-05-28 00:00:00

abstract：:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and i...

journal_title：British journal of cancer

authors： Noci I,Borri P,Bonfirraro G,Chieffi O,Arcangeli A,Cherubini A,Dabizzi S,Buccoliero AM,Paglierani M,Taddei GL

更新日期：2001-08-03 00:00:00

abstract：BACKGROUND:The eicosanoid signalling pathway promotes the progression of malignancies through the production of proliferative prostaglandins (PGs). Cytosolic phospholipase A(2)α (cPLA(2)α) activity provides the substrate for cyclooxygenase-dependent PG release, and we have previously found that cPLA(2)α expression corr...

journal_title：British journal of cancer

authors： Caiazza F,McCarthy NS,Young L,Hill AD,Harvey BJ,Thomas W

更新日期：2011-01-18 00:00:00

abstract：:Combretastatin-A4 phosphate (cis-CA-4) is a tubulin-binding agent currently undergoing clinical trials as an anti-tumour drug. We have investigated whether CA-4 functions as a tumour-specific anti-vascular agent using the hyperplastic thyroid as a novel in vivo model of neovascularization. CA-4 elicited pathological c...

journal_title：British journal of cancer

authors： Griggs J,Hesketh R,Smith GA,Brindle KM,Metcalfe JC,Thomas GA,Williams ED

更新日期：2001-03-23 00:00:00

abstract：:Reductions in cell-cell adhesion and stromal and vascular invasion are essential steps in the progression from localized malignancy to metastatic disease. In this study, changes in the expression of the components of the E-cadherin-catenin cell adhesion complex have been investigated using immunohistochemical techniqu...

journal_title：British journal of cancer

authors： Andrews NA,Jones AS,Helliwell TR,Kinsella AR

更新日期：1997-01-01 00:00:00

abstract：:A regional cancer network has been set up in the Rhône-Alpes region in France. The aim of the project is to improve the quality of care and to rationalize prescriptions in the network. In this network, we assessed the impact of the implementation of a clinical practice guidelines project by assessing the conformity of...

journal_title：British journal of cancer

authors： Ray-Coquard I,Philip T,de Laroche G,Froger X,Suchaud JP,Voloch A,Mathieu-Daudé H,Fervers B,Farsi F,Browman GP,Chauvin F

更新日期：2002-02-01 00:00:00

abstract：:This study has been designed to verify the specific toxicity of saporin, a type 1 ribosome-inactivating protein (RIP), with the same activity as ricin A chain, targeted by a bispecific monoclonal antibody (bimAb) recognising both the CD25 antigen and the RIP. The CD25 antigen is expressed by lymphoid populations upon ...

journal_title：British journal of cancer

authors： Tazzari PL,Zhang S,Chen Q,Sforzini S,Bolognesi A,Stirpe F,Xie H,Moretta A,Ferrini S

更新日期：1993-06-01 00:00:00

abstract：:Using a highly sensitive chemiluminescent enzyme immunoassay, we have evaluated the measurement of serum prostate-specific antigen (PSA) as a potential diagnostic test for differentiation between women with breast cancer and those with benign breast disease. In a controlled study consisting of 284 women with well-docu...

journal_title：British journal of cancer

authors： Romppanen J,Keskikuru R,Kataja V,Eskelinen M,Kosma VM,Savolainen K,Uusitupa M,Mononen I

更新日期：1999-03-01 00:00:00