Longstanding survival without cancer progression in a patient affected by endometrial carcinoma treated primarily with leuprolide.

Abstract:

:We report here a case of a patient affected by endometrial cancer and treated primarily with leuprolide, the surgical approach being unfeasible due to her compromised conditions. The therapy was continued for more than 6 years, and no progression of the disease was observed. During this period, some histological and immunohistochemical evaluations of the tumour (morphology, grading, proliferation and apoptotic index, E-cadherin expression) were performed. Furthermore, the expression of m-RNA for luteinizing-hormone releasing hormone (LHRH) receptors was determined. The results showed a discrepancy between some biological parameters of the tumour and its clinical characteristics. In fact, despite features suggestive of a progression of the cancer (such as the increase of both tumour grading and proliferating capacity (MIB-1), and a fall in the reparative process (appearance of mutated p53, reduced expression of both bcl-2 and c-erb-2) being detected, neither local invasion nor metastatic lesions were clinically observed. This discrepancy might be due to the maintenance of high levels of E-cadhezin. Moreover, since this tumour was shown to express mRNA for LHRH receptors, new evidence is provided about the favourable impact of LHRH analogue treatment in patients affected by endometrial cancer.

journal_name

Br J Cancer

authors

Noci I,Borri P,Bonfirraro G,Chieffi O,Arcangeli A,Cherubini A,Dabizzi S,Buccoliero AM,Paglierani M,Taddei GL

doi

10.1054/bjoc.2001.1900

subject

Has Abstract

pub_date

2001-08-03 00:00:00

pages

333-6

issue

3

eissn

0007-0920

issn

1532-1827

pii

S0007092001919007

journal_volume

85

pub_type

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