Cytosolic phospholipase A2-α expression in breast cancer is associated with EGFR expression and correlates with an adverse prognosis in luminal tumours.

abstract：BACKGROUND:HOX transcript antisense RNA (HOTAIR), which is expressed from the homebox C gene (HOXC) locus, is capable of reprogramming chromatin organisation and promoting cancer cell metastasis and can simultaneously bind the polycomb repressive complex 2, which enhances H3K27 trimethylation, and the LSD1-CoREST-REST ...

journal_title：British journal of cancer

authors： Li X,Wu Z,Mei Q,Li X,Guo M,Fu X,Han W

更新日期：2013-10-15 00:00:00

abstract：:In rats a maximal tolerated dose of carboplatin (60 mg kg-1, i.v.) caused severe anaemia, leucopenia and thrombocytopenia. These indices of haematological toxicity were also observed with a maximal tolerated dose of cis-platin (6.5 mg kg-1, i.v.), but reductions in blood cell counts were less than those observed with ...

journal_title：British journal of cancer

authors： Siddik ZH,Boxall FE,Harrap KR

更新日期：1987-04-01 00:00:00

abstract：:All hospital-treated cases of Burkitt's lymphoma (BL), with onset of symptoms in the period 1963-68 and resident in the Lango and Acholi districts of Uganda, were identified. The average annual incidence of BL in the 6-year period was 1-87 X 10(-5), similar to that in the adjacent West Nile district. Contrary to findi...

journal_title：British journal of cancer

authors： Morrow RH,Pike MC,Smith PG

更新日期：1977-05-01 00:00:00

abstract：:Natural human interferon beta (beta-IFN) was tested during the early phase of in vitro infection with HTLV-I virus of human cord blood mononuclear cells (CBL), to evaluate whether its antiviral and immunomodulating effects might prevent spreading of infection in the host. beta-IFN was found to reduce HTLV-I transmissi...

journal_title：British journal of cancer

authors： D'Onofrio C,Perno CF,Mazzetti P,Graziani G,Calio' R,Bonmassar E

更新日期：1988-05-01 00:00:00

abstract：:Forty-two patients with small cell lung cancer were treated with a combination of carboplatin, ifosfamide and etoposide. Vincristine was given on day 14 of each course, the courses being repeated every 28 days for a maximum of six. Thoracic radiotherapy was given 4 weeks after the last course of chemotherapy but no pr...

journal_title：British journal of cancer

authors： Thatcher N,Lind M,Stout R,Payne C,Carroll KB,Campbell C,Moussalli H

更新日期：1989-07-01 00:00:00

abstract：:This corrects the article DOI: 10.1038/bjc.2017.85. ...

journal_title：British journal of cancer

authors： Trudel-Fitzgerald C,Zhou ES,Poole EM,Zhang X,Michels KB,Eliassen AH,Chen WY,Holmes MD,Tworoger SS,Schernhammer ES

更新日期：2018-03-20 00:00:00

abstract：:The relationship between oestrogen receptor (RE) content of primary breast cancer and subsequent prognosis was examined with regard to nodal status. It was found that, within a particular nodal group, patients with tumours containing fully functional RE experienced a longer disease-free interval than those with RE- di...

journal_title：British journal of cancer

authors： Leake RE,Laing L,McArdle C,Smith DC

更新日期：1981-01-01 00:00:00

abstract：:High-mol.-wt levan injected locally inhibits the growth of Lewis lung carcinoma in C57BL mice. The inhibition is dependent on the number of tumour cells injected and on the dose of levan. The inhibition decreases tumour incidence and size as well as prolonging survival. The polysaccharide is most effective when inject...

journal_title：British journal of cancer

authors： Leibovici J,Borit A,Sandbank U,Wolman M

更新日期：1979-10-01 00:00:00

abstract：:Recent evidence has demonstrated that endothelial-to-mesenchymal transition (EndMT) may have a significant role in a number of diseases. Although EndMT has been previously studied as a critical process in heart development, it is now clear that EndMT can also occur postnatally in various pathologic settings, including...

journal_title：British journal of cancer

authors： Potenta S,Zeisberg E,Kalluri R

更新日期：2008-11-04 00:00:00

abstract：:In the endeavour to develop a model for studying gene therapy of cancers associated with human papillomaviruses (HPVs), mouse cells were transformed with the HPV type 16 (HPV16) and activated H-ras oncogenes. This was done by cotransfection of plasmid p16HHMo, carrying the HPV16 E6/E7 oncogenes, and plasmid pEJ6.6, ca...

journal_title：British journal of cancer

authors： Smahel M,Sobotková E,Bubeník J,Símová J,Zák R,Ludviková V,Hájková R,Kovarík J,Jelínek F,Povýsil C,Marinov J,Vonka V

更新日期：2001-02-02 00:00:00

abstract：BACKGROUND:Vismodegib has been used for the treatment of locally advanced basal cell carcinoma (laBCC) and metastatic BCC (mBCC) since 2011. Most efficacy and safety data are provided by clinical trials. This study evaluates the effectiveness of vismodegib for the treatment of laBCC, mBCC and basal cell nevus syndrome ...

journal_title：British journal of cancer

authors： Verkouteren BJA,Wakkee M,Reyners AKL,Nelemans P,Aarts MJB,Rácz E,Terra JB,Devriese LA,Alers RJ,Kapiteijn E,van Doorn R,Bekkenk MW,Reinders MGHC,Mosterd K

更新日期：2021-01-19 00:00:00

abstract：BACKGROUND:LIM and SH3 protein 1 (LASP-1) is a nucleo-cytoplasmatic signalling protein involved in cell proliferation and migration and is upregulated in breast cancer in vitro studies have shown that LASP-1 might be regulated by prostate-derived ETS factor (PDEF), p53 and/or LASP1 gene amplification. This current stud...

journal_title：British journal of cancer

authors： Frietsch JJ,Grunewald TG,Jasper S,Kammerer U,Herterich S,Kapp M,Honig A,Butt E

更新日期：2010-05-25 00:00:00

abstract：:Seventy three children with rhabdomyosarcoma were treated by members of the Children's Solid Tumour Group during the period, 1974-1981. The extent of disease at diagnosis was found to be the major influence affecting outcome. Children with tumours confined to the tissue of origin with no evidence of nodal or metastati...

journal_title：British journal of cancer

authors： Kingston JE,McElwain TJ,Malpas JS

更新日期：1983-08-01 00:00:00

abstract：:Benzoporphyrin derivative monoacid ring A (BPD-MA, verteporfin) is currently under investigation as a photosensitizer for photodynamic therapy (PDT). Since BPD exhibits rapid pharmacokinetics in plasma and tissues, we assessed damage to tumour and muscle microvasculature when light treatment for PDT was given at short...

journal_title：British journal of cancer

authors： Fingar VH,Kik PK,Haydon PS,Cerrito PB,Tseng M,Abang E,Wieman TJ

更新日期：1999-04-01 00:00:00

abstract：:Common warts could indicate cervical cancer susceptibility, as both are caused by human papillomavirus (HPV). Eczema was also investigated, as atopic eczema has been negatively associated with warts, but non-atopic eczema may be associated with compromised host defences, as observed in patients with HIV, suggesting in...

journal_title：British journal of cancer

authors： Montgomery SM,Ehlin AG,Sparén P,Björkstén B,Ekbom A

更新日期：2002-10-21 00:00:00

abstract：BACKGROUND:The poor prognosis of patients with colorectal-cancer liver metastases (CRLM) and the insufficiency of available treatments have raised the need for alternative curative strategies. We aimed to assess the therapeutic potential of TL-118, a new anti-angiogenic drug combination, for CRLM treatment, in a mouse ...

journal_title：British journal of cancer

authors： Edrei Y,Gross E,Corchia N,Abramovitch R

更新日期：2012-08-07 00:00:00

abstract：:The aim of the present study was to evaluate the occult lymph node carcinomatous diffusion in head and neck squamous cell carcinoma (HNSCC). A total of 1328 lymph nodes from 31 patients treated between 2004 and 2005 were prospectively evaluated by routine haematoxylin-eosin-safran (HES) staining, immunohistochemistry ...

journal_title：British journal of cancer

authors： Tao L,Lefèvre M,Ricci S,Saintigny P,Callard P,Périé S,Lacave R,Bernaudin JF,Lacau St Guily J

更新日期：2006-04-24 00:00:00

abstract：BACKGROUND:The prognosis of squamous cell carcinoma of the oral tongue is poor and it would be beneficial to find prognostic markers to better adjust treatment. Bmi-1 controls cell cycle and self-renewal of tissue stem cells, transcription factor c-myc affects cell proliferation and apoptosis, and Snail regulates epith...

journal_title：British journal of cancer

authors： Häyry V,Mäkinen LK,Atula T,Sariola H,Mäkitie A,Leivo I,Keski-Säntti H,Lundin J,Haglund C,Hagström J

更新日期：2010-03-02 00:00:00

abstract：BACKGROUND:Abiraterone and enzalutamide are novel endocrine treatments that abrogate androgen receptor (AR) signalling in castration-resistant prostate cancer (CRPC). Here, we developed a circulating tumour cells (CTCs)-based assay to evaluate AR expression in real-time in CRPC and investigated nuclear AR expression in...

journal_title：British journal of cancer

authors： Crespo M,van Dalum G,Ferraldeschi R,Zafeiriou Z,Sideris S,Lorente D,Bianchini D,Rodrigues DN,Riisnaes R,Miranda S,Figueiredo I,Flohr P,Nowakowska K,de Bono JS,Terstappen LW,Attard G

更新日期：2015-03-31 00:00:00

abstract：:Tamoxifen is currently established as the endocrine treatment of choice in breast cancer. In advanced breast cancer, response rates of up to 60% in women with oestrogen receptor (ER)-positive tumours have been reported. In early breast cancer, tamoxifen can produce significant benefits, both statistically and clinical...

journal_title：British journal of cancer

authors： Baum M

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:MEK is activated in ∼40% colorectal cancer (CRC) and 20-30% non-small cell lung cancer (NSCLC). Selumetinib is a selective inhibitor of MEK1/2, which is currently in clinical development. METHODS:We evaluated the effects of selumetinib in vitro and in vivo in CRC and NSCLC cell lines to identify cancer cell...

journal_title：British journal of cancer

authors： Troiani T,Vecchione L,Martinelli E,Capasso A,Costantino S,Ciuffreda LP,Morgillo F,Vitagliano D,D'Aiuto E,De Palma R,Tejpar S,Van Cutsem E,De Lorenzi M,Caraglia M,Berrino L,Ciardiello F

更新日期：2012-05-08 00:00:00

abstract：:A cytogenetic study was performed in 27 patients suspected of t-MDS or t-ANLL. In 12 patients the diagnosis of t-MDS or t-ANLL was confirmed by morphological, cytochemical and immunophenotypical analysis. The cases were classified as RA (one), RAEB (four), CMML (two), ANLL (five). They had received chemotherapy and/or...

journal_title：British journal of cancer

authors： Sozzi G,Miozzo M,Orazi A,Calderone C,Castellano M,Viviani S,Santoro A,Pierotti MA,Della Porta G

更新日期：1990-03-01 00:00:00

abstract：:The primary aim of this study was to investigate if the expression of the DNA damage identifying protein DNA-PKcs known to be involved in DNA repair after treatment with ionising radiation can be used as a predictive marker for radiotherapy (RT) response in cervical cancer. Formalin-fixed primary tumour biopsies from ...

journal_title：British journal of cancer

authors： Beskow C,Kanter L,Holgersson A,Nilsson B,Frankendal B,Avall-Lundqvist E,Lewensohn R

更新日期：2006-06-05 00:00:00

abstract：BACKGROUND:This phase 1 study examined the safety, maximum-tolerated dose (MTD) and antitumour activity of E7449, a novel PARP 1/2 and tankyrase 1/2 inhibitor. METHODS:E7449 was orally administered once daily in 28-day cycles to patients with advanced solid tumours (50-800-mg doses). Archival tumour samples from conse...

journal_title：British journal of cancer

authors： Plummer R,Dua D,Cresti N,Drew Y,Stephens P,Foegh M,Knudsen S,Sachdev P,Mistry BM,Dixit V,McGonigle S,Hall N,Matijevic M,McGrath S,Sarker D

更新日期：2020-08-01 00:00:00

abstract：:Cancer survival rates decrease in the presence of disseminated disease. However, there are few therapies that are effective at eliminating the primary tumour while providing control of distant stage disease. Photodynamic therapy (PDT) is an FDA-approved modality that rapidly eliminates local tumours, resulting in cure...

journal_title：British journal of cancer

authors： Kabingu E,Vaughan L,Owczarczak B,Ramsey KD,Gollnick SO

更新日期：2007-06-18 00:00:00

abstract：:The neuropsychological performance of 85 women with early stage breast cancer scheduled for chemotherapy, 43 women scheduled for endocrine therapy and/or radiotherapy and 49 healthy control subjects was assessed at baseline (T1), postchemotherapy (or 6 months) (T2) and at 18 months (T3). Repeated measures analysis fou...

journal_title：British journal of cancer

authors： Jenkins V,Shilling V,Deutsch G,Bloomfield D,Morris R,Allan S,Bishop H,Hodson N,Mitra S,Sadler G,Shah E,Stein R,Whitehead S,Winstanley J

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:A Population-Based Cancer Registry (PBCR) was set up in Sikkim (a state in the North Eastern India) in 2003. We examined incidence rates by ethnic groups from 2003-2008. METHODS:Age-adjusted incidence rates (AARs) per 100,000 person-years were calculated by direct method using the world standard population,...

journal_title：British journal of cancer

authors： Verma Y,Pradhan PK,Gurung N,Sapkota SD,Giri P,Sundas P,Bhattarai BN,Nadayil D,Ramnath T,Nandakumar A

更新日期：2012-02-28 00:00:00

abstract：:Nuclear polyploidization in the livers of CF-1 mice, exposed to dieldrin (0, 1, 5 and 10 ppm in the diet), was studied up to the median time of liver tumour development (ranging from 15 to 27 months) in the respective treatment groups. In untreated controls nuclear polyploidization is characterized by a linear increas...

journal_title：British journal of cancer

authors： van Ravenzwaay B,Kunz W

更新日期：1988-07-01 00:00:00

abstract：:Human monocytes can be induced to synthesize a cytotoxin which affects certain tumour cell lines. The interaction of monocyte cytotoxin with a susceptible cell line (L929) has been studied to obtain clues to the mode of action of the cytotoxin. The cytotoxin acts directly on the cells rather than on the culture medium...

journal_title：British journal of cancer

authors： Matthews N

更新日期：1983-09-01 00:00:00

abstract：:To study the effect of oral supplemental calcium on colonic epithelial proliferation, 17 adenomatous polyp patients received 1.5 g Ca2+ as calcium carbonate daily during 12 weeks, while on a calcium constant diet, based on the patients' habitual diet. Seven subsequently continued calcium supplementation for 9 months w...

journal_title：British journal of cancer

authors： Kleibeuker JH,Welberg JW,Mulder NH,van der Meer R,Cats A,Limburg AJ,Kreumer WM,Hardonk MJ,de Vries EG

更新日期：1993-03-01 00:00:00