Detection of occult carcinomatous diffusion in lymph nodes from head and neck squamous cell carcinoma using real-time RT-PCR detection of cytokeratin 19 mRNA.

abstract：:Despite encouraging results from recent studies, there is still no consensus to undertake mass screening using the Haemoccult test in the general population. The success of mass screening for colorectal cancer depends among other things on Haemoccult test properties. In on-going screening programmes, the Haemoccult te...

journal_title：British journal of cancer

authors： Launoy G,Herbert C,Reaud JM,Thezee Y,Tichet J,Maurel J,Ollivier V,Pegulu L,Caces E,Valla A

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide. We tested megestrol acetate (MA) against placebo in the treatment of advanced HCC. METHODS:From 2002 through 2007, this randomised double-blind trial enrolled 204 patients with treatment-naive advanced HCC (Eastern Coopera...

journal_title：British journal of cancer

authors： Chow PK,Machin D,Chen Y,Zhang X,Win KM,Hoang HH,Nguyen BD,Jin MY,Lobo R,Findlay M,Lim CH,Tan SB,Gandhi M,Soo KC,Asia-Pacific Hepatocellular Carcinoma Trials Group.

更新日期：2011-09-27 00:00:00

abstract：:Although epithelial cell adhesion/activating molecule (EpCAM/CD326) is one of the first tumour-associated antigens identified, it has never received the same level of attention as other target proteins for therapy of cancer. It is also striking that ever since its discovery in the late 1970s the actual contribution of...

journal_title：British journal of cancer

authors： Baeuerle PA,Gires O

更新日期：2007-02-12 00:00:00

abstract：:Differentiation-inducing ability of gamma-radiation, N,N-dimethylformamide and their combination has been tested on human rhabdomyosarcoma RMZ-RC2 clone cells. Ionising radiation at 2-5 Gy doses induced a more differentiated morphology, with the appearance of an increased proportion of multinuclear myotube-like cells,...

journal_title：British journal of cancer

authors： Nicoletti G,De Giovanni C,Landuzzi L,Simone G,Rocchi P,Nanni P,Lollini PL

更新日期：1992-04-01 00:00:00

abstract：PURPOSE:To determine the feasibility of induction chemotherapy and chemo-IMRT in head and neck squamous cell cancers at risk of bilateral nodal spread (midline tumours) and to evaluate whether bilateral superficial lobe parotid-sparing IMRT can reduce the incidence of ⩾G2 subjective xerostomia. METHODS:Patients with m...

journal_title：British journal of cancer

authors： Miah AB,Schick U,Bhide SA,Guerrero-Urbano MT,Clark CH,Bidmead AM,Bodla S,Del Rosario L,Thway K,Wilson P,Newbold KL,Harrington KJ,Nutting CM

更新日期：2015-01-06 00:00:00

abstract：:Anti-vascular effects of the novel Vinca alkaloid, vinflunine have been investigated in the MAC 15A transplantable murine colon adenocarcinoma model and compared with those induced by the most recently identified clinically useful third generation Vinca. Administration of the maximum tolerated dose of either vinflunin...

journal_title：British journal of cancer

authors： Holwell SE,Hill BT,Bibby MC

更新日期：2001-01-01 00:00:00

abstract：:To investigate the association between medullary carcinoma of the thyroid (MCT) and carcinoembryonic antigen (CEA), we assayed 78 sera from patients with thyroid diseases for CEA, employing the radioimmunoassay of double antibody technique. All 13 sera from patients with MCT had high levels of CEA, ranging from 14 to ...

journal_title：British journal of cancer

authors： Ishikawa N,Hamada S

更新日期：1976-08-01 00:00:00

abstract：BACKGROUND:Heterogeneity and low incidence comprise the biggest challenge in sarcoma diagnosis and treatment. Chemotherapy, although efficient for some sarcoma subtypes, generally results in poor clinical responses and is mostly recommended for advanced disease. Specific genomic aberrations have been identified in some...

journal_title：British journal of cancer

authors： Brodin BA,Wennerberg K,Lidbrink E,Brosjö O,Potdar S,Wilson JN,Ma L,Moens LN,Hesla A,Porovic E,Bernhardsson E,Papakonstantinou A,Bauer H,Tsagkozis P,von Sivers K,Wejde J,Östling P,Kallioniemi O,Stragliotto CL

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Patients with high-grade gliomas are treated with surgery followed by chemoradiation. The risk factors and implications of neurological side effects are not known. METHODS:Acute and late ≥ grade 3 neurological toxicities (NTs) were analysed among 2761 patients from 14 RTOG trials accrued from 1983 to 2003. ...

journal_title：British journal of cancer

authors： Lawrence YR,Wang M,Dicker AP,Andrews D,Curran WJ Jr,Michalski JM,Souhami L,Yung WK,Mehta M

更新日期：2011-04-26 00:00:00

abstract：BACKGROUND:Previous studies have demonstrated that senescent cancer-associated fibroblasts (CAFs) derived from genetically unstable oral squamous cell carcinomas (GU-OSCC), unlike non-senescent CAFs from genetically stable carcinomas (GS-OSCC), promoted keratinocyte invasion in vitro in a paracrine manner. The mechanis...

journal_title：British journal of cancer

authors： Hassona Y,Cirillo N,Heesom K,Parkinson EK,Prime SS

更新日期：2014-09-09 00:00:00

abstract：:Fine-needle aspiration cytology, which is well established to be accurate for the diagnosis of thyroid cancer, may be inconclusive for the follicular thyroid neoplasms. As galectin-3 was suggested to be a marker of malignant thyrocytes, we investigated whether this protein might be helpful in the diagnosis of aspirate...

journal_title：British journal of cancer

authors： Collet JF,Hurbain I,Prengel C,Utzmann O,Scetbon F,Bernaudin JF,Fajac A

更新日期：2005-11-14 00:00:00

abstract：:We investigated expression of a human p53-inducible gene, P2XM, a member of the P2X-receptor family of ATP-gated ion channels, in 56 human primary soft-tissue tumours including 47 sarcomas and nine benign tumors. Among the 47 sarcomas examined by reverse transcription polymerase chain reaction, 12 had lost expression ...

journal_title：British journal of cancer

authors： Nawa G,Miyoshi Y,Yoshikawa H,Ochi T,Nakamura Y

更新日期：1999-06-01 00:00:00

abstract：:The aim of this study was to find a procedure allowing estimation of individual pharmacokinetic parameters for adriamycin with minimal cost and disturbance for the patient. Twenty-five patients with breast cancer were treated by short infusion of adriamycin at a dose of 12 mg m-2 week-1 (41 courses). Population charac...

journal_title：British journal of cancer

authors： Launay MC,Milano G,Iliadis A,Frenay M,Namer N

更新日期：1989-07-01 00:00:00

abstract：:Endosialin is a transmembrane glycoprotein selectively expressed in blood vessels and stromal fibroblasts of various human tumours. It has been functionally implicated in angiogenesis, but the factors that control its expression have remained unclear. As insufficient delivery of oxygen is a driving force of angiogenes...

journal_title：British journal of cancer

authors： Ohradanova A,Gradin K,Barathova M,Zatovicova M,Holotnakova T,Kopacek J,Parkkila S,Poellinger L,Pastorekova S,Pastorek J

更新日期：2008-10-21 00:00:00

abstract：:Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method. The aim of this study was to elucidate a possible association of FGF-3 copy numbers with established prognostic factors such as age, histology,...

journal_title：British journal of cancer

authors： Rosen A,Sevelda P,Klein M,Dobianer K,Hruza C,Czerwenka K,Hanak H,Vavra N,Salzer H,Leodolter S

更新日期：1993-05-01 00:00:00

abstract：:Multiple primary tumours occurring in a three-year population-based series of patients with histopathologically peer-reviewed sarcomas from North West England were ascertained in order to look at the patterns of neoplasms seen. A total of 30 out of the 310 patients entered in the study had additional primary tumours. ...

journal_title：British journal of cancer

authors： Hartley AL,Blair V,Harris M,Birch JM,Banerjee SS,Freemont AJ,McClure J,McWilliam LJ

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development of several human cancers. The present study was conducted to investigate the expression of GOLPH3 and its prognostic significance in renal cell carcinoma (RCC). Meanwhile, the function of GOLPH3 in human RCC was further inves...

journal_title：British journal of cancer

authors： Xue Y,Wu G,Liao Y,Xiao G,Ma X,Zou X,Zhang G,Xiao R,Wang X,Liu Q,Long D,Yang J,Xu H,Liu F,Liu M,Xie K,Huang R

更新日期：2014-04-29 00:00:00

abstract：BACKGROUND:To date, there are few reports on gene products contributing to colon cancer progression. METHODS:We used a gene trap comprised of an enhanced retroviral mutagen (ERM) cassette that includes a tetracycline-responsive promoter upstream of a haemagglutinin (HA) tag and a splice donor site. Integration of the ...

journal_title：British journal of cancer

authors： Ishiguro T,Avila H,Lin SY,Nakamura T,Yamamoto M,Boyd DD

更新日期：2010-02-16 00:00:00

abstract：:Previous studies have reported the clinical usefulness of reverse transcription-polymerase chain reaction (RT-PCR) detection of thyroglobulin (TG) mRNA in the peripheral blood of patients with differentiated thyroid carcinoma. To evaluate this usefulness, we measured TG mRNA in the peripheral blood of patients diagnos...

journal_title：British journal of cancer

authors： Takano T,Miyauchi A,Yoshida H,Hasegawa Y,Kuma K,Amino N

更新日期：2001-07-06 00:00:00

abstract：BACKGROUND:Paired related homoeobox 1 (PRRX1) has been identified as a new epithelial-mesenchymal transition (EMT) inducer in breast cancer. However, the function of PRRX1 in colorectal cancer (CRC) has not been elucidated. METHODS:We utilised ectopic PRRX1-expressing cell lines to analyse the function of PRRX1 in CRC...

journal_title：British journal of cancer

authors： Takahashi Y,Sawada G,Kurashige J,Uchi R,Matsumura T,Ueo H,Takano Y,Akiyoshi S,Eguchi H,Sudo T,Sugimachi K,Doki Y,Mori M,Mimori K

更新日期：2013-07-23 00:00:00

abstract：:Cells from V79 multicell spheroids must be exposed to approximately 50 times more etoposide than exponentially growing monolayers in order to produce the same amount of cell killing. A part of this difference in sensitivity is readily explained by the decrease in growth fraction of large spheroids, and by the protecti...

journal_title：British journal of cancer

authors： Olive PL,Banáth JP,Evans HH

更新日期：1993-03-01 00:00:00

abstract：:We carried out a comparison of three commonly used mucin markers, CA549, CA15.3 and MCA. Serum samples from 184 healthy women and 237 patients with primary breast cancer were evaluated. The markers were measured using commercially available immunometric assays. Like CA15.3 and MCA, CA549 was significantly associated w...

journal_title：British journal of cancer

authors： Gion M,Plebani M,Mione R,Penzo C,Meo S,Burlina A

更新日期：1994-04-01 00:00:00

abstract：:Male and female Swiss strain mice were put on a 0.03% thioacetamide diet at the age of 2 months. Control mice were kept on a stock diet. Control and treated mice were killed at the ages of 6, 9, 13 and 17 months. Progressive morphological, histological and biochemical alterations in the liver and tumour tissue of the ...

journal_title：British journal of cancer

authors： Gothoskar SV,Talwalkar GV,Bhide SV

更新日期：1970-09-01 00:00:00

abstract：BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women ...

journal_title：British journal of cancer

authors： Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SE

更新日期：2012-09-25 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Non-persistence and non-compliance are common in women prescribed hormonal therapy for breast cancer, but little is known about their influence on recurrence. METHODS:A nested case-control study of associations between hormonal therapy non-persistence and non-compliance and the risk of early recurrence in w...

journal_title：British journal of cancer

authors： Barron TI,Cahir C,Sharp L,Bennett K

更新日期：2013-09-17 00:00:00

abstract：:We examined the relationship between p53 levels before and after irradiation, radiation-induced cell cycle delays, apoptotic cell death and radiosensitivity in a panel of eight human tumour cell lines. The cell lines differed widely in their clonogenic survival after radiation, (surviving fraction at 2 Gy: SF2=0.18-0....

journal_title：British journal of cancer

authors： Siles E,Villalobos M,Valenzuela MT,Núñez MI,Gordon A,McMillan TJ,Pedraza V,Ruiz de Almodóvar JM

更新日期：1996-03-01 00:00:00

abstract：:Cellular senescence is an established tumour-suppressive mechanism that prevents the proliferation of premalignant cells. However, several lines of evidence show that senescent cells, which often persist in vivo, can also promote tumour progression in addition to other age-related pathologies via the senescence-associ...

journal_title：British journal of cancer

authors： Lecot P,Alimirah F,Desprez PY,Campisi J,Wiley C

更新日期：2016-05-24 00:00:00

abstract：:Markers of the inflammatory response, interleukin 6, C-reactive protein, albumin and full blood count, were measured in non-small-cell lung cancer (NSCLC) patients (n = 21) with and without weight loss ( > 5%). There were significant increases in circulating C-reactive protein (P < 0.001), interleukin 6 (P < 0.01) and...

journal_title：British journal of cancer

authors： Scott HR,McMillan DC,Crilly A,McArdle CS,Milroy R

更新日期：1996-06-01 00:00:00

abstract：:Temozolomide, an oral cytotoxic agent with approximately 100% bioavailability after one administration, has demonstrated schedule-dependent clinical activity against highly resistant cancers. Thirty patients with minimal prior chemotherapy were enrolled in this phase I trial to characterize the drug's safety, pharmaco...

journal_title：British journal of cancer

authors： Brada M,Judson I,Beale P,Moore S,Reidenberg P,Statkevich P,Dugan M,Batra V,Cutler D

更新日期：1999-11-01 00:00:00