Abstract:
BACKGROUND:Around 60% of women ≥ 80 years old, in the UK do not have surgery for their breast cancer (vs<10% of younger age groups). The extent to which this difference can be accounted for by co-morbidity has not been established. METHODS:A Cancer Registry/Hospital Episode Statistics-linked data set identified women aged ≥ 65 years diagnosed with invasive breast cancer (between 1 April 1997 and 31 March 2005) in two regions of the UK (n=23038). Receipt of surgery by age was investigated using logistic regression, adjusting for co-morbidity and other patient, tumour and treatment factors. RESULTS:Overall, 72% of older women received surgery, varying from 86% of 65-69-year olds to 34% of women aged ≥ 85 years. The proportion receiving surgery fell with increasing co-morbidity (Charlson score 0=73%, score 1=66%, score 2+=49%). However, after adjustment for co-morbidity, older age still predicts lack of surgery. Compared with 65-69-year olds, the odds of surgery decreased from 0.74 (95% CI: 0.66-0.83) for 70-74-year olds to 0.13 (95% CI: 0.11-0.14) for women aged ≥ 85 years. CONCLUSION:Although co-morbidity is associated with a reduced likelihood of surgery, it does not explain the shortfall in surgery amongst older women in the UK. Routine data on co-morbidity enables fairer comparison of treatment across population groups but needs to be more complete.
journal_name
Br J Cancerjournal_title
British journal of cancerauthors
Lavelle K,Downing A,Thomas J,Lawrence G,Forman D,Oliver SEdoi
10.1038/bjc.2012.192subject
Has Abstractpub_date
2012-09-25 00:00:00pages
1175-80issue
7eissn
0007-0920issn
1532-1827pii
bjc2012192journal_volume
107pub_type
杂志文章abstract::In premenopausal women with advanced breast cancer the luteinising hormone-releasing hormone agonist goserelin (Zoladex, ICI plc) will produce serum levels of oestradiol equivalent to those following surgical oophorectomy or the menopause. This paper reports our further experience of using this drug in 75 premenopausa...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1990.397
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:CD26 is a multifunctional membrane-bound glycoprotein that regulates tumour growth in addition to its other activities. Because disease aggressiveness is correlated with CD26 expression in several T-cell malignancies, we decided to investigate the invasiveness of cells expressing different levels of CD26. M...
journal_title:British journal of cancer
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1978-02-01 00:00:00
abstract:BACKGROUND:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obes...
journal_title:British journal of cancer
pub_type: 杂志文章,meta分析
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更新日期:2017-05-23 00:00:00
abstract::Changes in the buccal mucosa of 296 Indian and Malay betel-nut chewers in Perak, West Malaysia, were studied clinically. 167 out of 212 Indian subjects incorporated tobacco in their quids, while 45 out of 84 Malay subjects incorporated. "Gambir". The Indians appeared to show a higher proportion of mucosal changes, par...
journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2000-01-01 00:00:00
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doi:10.1054/bjoc.2000.1582
更新日期:2001-02-02 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.2012.496
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abstract::Fifty-two previously untreated patients with advanced non-small-cell lung cancer (NSCLC) were treated on a 14 day cycle with cisplatin (60 mg m-2 i.v.) and vindesine (3 mg m-2 i.v.) on day 1, followed by a 3 day continuous infusion of 5-fluorouracil (800 mg m-2 day-1) starting on day 8. An overall response rate of 40....
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更新日期:2014-09-23 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章,评审
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更新日期:2011-01-04 00:00:00
abstract::The effect of an antiserum containing antibodies against cell surface components of PyBHK cells on the action of certain anticancer agents has been studied using a colony formation inhibition assay. The effects of x-rays, chlorambucil, CCNU and possibly ICRF 159 are augmented by the antiserum whereas methotrexate and ...
journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1975.234
更新日期:1975-09-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
doi:10.1038/bjc.1991.146
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abstract::Cellular mechanisms that account for tumour osteolysis associated with Ewing's sarcoma are uncertain. Osteoclasts are marrow-derived multinucleated cells (MNCs) that effect tumour osteolysis. Osteoclasts are known to form from macrophages by both receptor activator for nuclear factor-kappaB (RANK) ligand (RANKL)-depen...
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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更新日期:2018-05-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:2005-06-06 00:00:00
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pub_type: 杂志文章
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1997-01-01 00:00:00
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journal_title:British journal of cancer
pub_type: 杂志文章
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更新日期:1990-04-01 00:00:00